Sie suchten nach: megakaryocytter (Dänisch - Englisch)

Øget knoglemarvsretikulin menes at være et resultat af stimulering af tpo-receptorerne, hvilket resulterer i et øget antal megakaryocytter i knoglemarven, som efterfølgende kan afgive cytokiner.
increased bone marrow reticulin is believed to be a result of tpo receptor stimulation, leading to an increased number of megakaryocytes in the bone marrow, which may subsequently release cytokines.

in vitro undersøgelser af human megakaryocytopoiese har fastslået, at anagrelids hæmmende virkning på dannelsen af blodplader hos mennesker fremkaldes via forsinkelse af modningen af megakaryocytter, og ved at reducere deres størrelse og ploidi.
in vitro studies of human megakaryocytopoiesis established that anagrelide’s inhibitory actions on platelet formation in man are mediated via retardation of maturation of megakaryocytes, and reducing their size and ploidy.

romiplostims farmakokinetik involverede target-medieret aflejring, hvilket antageligt medieres af tpo-receptorer på trombocytter og andre celler af trombopoietisk afstamning, såsom megakaryocytter.
the pharmacokinetics of romiplostim involved target-mediated disposition, which is presumably mediated by tpo receptors on platelets and other cells of the thrombopoietic lineage such as megakaryocytes.

denne non-lineære reduktion i fordelingsvolumen svarer til den (megakaryocyt og trombocyt) target-medierede binding af romiplostim, som kan være mættet ved de højere anvendte doser.
this non-linear decrease in volume of distribution is in line with the (megakaryocyte and platelet) target-mediated binding of romiplostim, which may be saturated at the higher doses applied.