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bedømmelsen af mikrokerne kan således begrænses til celler, der har undergået mitose under eller efter behandling.
micronucleus scoring, therefore, can be limited to cells that have gone through mitosis during or after treatment.
cytokinese celledeling umiddelbart efter mitose, hvorved der dannes to datterceller, som hver indeholder en enkelt kerne.
cytokinesis the process of cell division immediately following mitosis to form two daughter cells, each containing a single nucleus.
mitose deling af cellekernen, der normalt inddeles i profase, prometafase, metafase, anafase og telofase.
mitosis division of the cell nucleus usually divided into prophase, prometaphase, metaphase, anaphase and telophase.
i denne tm kan der desuden anvendes protokoller uden cytokineseblokerende stof, hvis det kan dokumenteres, at analyserede cellepopulation har undergået mitose.
this tm also allows the use of protocols without cytokinesis block, provided there is evidence that the cell population analysed has undergone mitosis.
denne stabilitet resulterer i hæmningen af den normale dynamiske reorganisering af netværket a mikrotubuli, der er afgørende for nødvendige cellefunktioner i interfase og mitose.
this stability results in the inhibition of the normal dynamic reorganisation of the microtubule network that is essential for vital interphase and mitotic cellular functions.
erythropoietin er et glykoprotein, der stimulerer dannelsen af erytrocytter fra erythrocyt- forstadier fra stamceller ved at stimulere mitose og ved at være et differentierende hormon.
erythropoietin is a glycoprotein that stimulates, as a mitosis-stimulating factor and differentiating hormone, the formation of erythrocytes from precursors of the stem cell compartment.
hvis der iagttages såvel mitose som meiose, bestemmes forholdet mellem spermatogonmitoser og første og anden meiosemetafase som et mål for cytotoksiciteten for alle behandlede dyr og negative kontroldyr i en samlet prøve på 100 celler under deling for hvert dyr.
if mitosis as well as meiosis is observed, the ratio of spermatogonial mitoses to first and second meiotic metaphases should be determined as a measure of cytotoxicity for all treated and negative control animals in a total sample of 100 dividing cells per animal to establish a possible cytotoxic effect.
det er vigtigt at indsamle disse celler, når kulturerne vaskes, og at føre dem tilbage til kulturerne for ikke at miste celler, der er i mitose, og hvor der er risiko for dannelse af mikrokerner på høsttidspunktet.
care should be taken to collect these when cultures are washed, and to return them to the cultures, to avoid losing cells that are in mitosis, and at risk for micronuclei, at the time of harvest.
in vitro-forsøg har vist, at docetaxel ødelægger det mikrotubulære netværk i celler, som er essentielle for mitosen og cellulære funktioner i interfasen.
docetaxel has been shown in vitro to disrupt the microtubular network in cells which is essential for vital mitotic and interphase cellular functions.