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Results for sapropteriinidihydrokloridihoidolle translation from Finnish to English

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Finnish

Erillisessä 10 viikkoa kestäneessä plasebo-kontrolloidussa tutkimuksessa 45 PKU-potilasta, joiden veren fenyylialaniinitasoja kontrolloitiin vakiintuneella fenyylialaniinin suhteen rajoitetulla ruokavaliolla (veren fenyylialaniini ≤ 480 µmol/l tutkimukseen mukaantulovaiheessa), satunnaistettiin 3:1 sapropteriinidihydrokloridihoidolle 20 mg/kg/vrk (n=33) tai plasebolle (n=12).

English

In a separate 10-week, placebo-controlled study, 45 PKU patients with blood phenylalanine levels controlled on a stable phenylalanine-restricted diet (blood phenylalanine ≤480 μmol/l on enrolment) were randomized 3:1 to treatment with sapropterin dihydrochloride 20 mg/kg/day (n=33) or placebo (n=12).

Last Update: 2017-04-26
Usage Frequency: 1
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Finnish

Sapropteriinihoitoa saaneiden ryhmässä ravinnon mukana tulevan fenyylialaniinin siedettävyys oli 38,4 ± 21,6 mg/kg/vrk (keskiarvo ± SD) sapropteriinidihydrokloridihoidon aikana annoksella 20 mg/kg/vrk, verrattuna 15,7 ± 7,2 mg/kg/vrk ennen hoidon aloitusta.

English

For the sapropterin treatment group, the mean ± SD total dietary phenylalanine tolerance was 38.4 ± 21.6 mg/kg/day during treatment with sapropterin dihydrochloride 20 mg/kg/day compared to 15.7 ± 7.2 mg/kg/day before treatment.

Last Update: 2017-04-26
Usage Frequency: 1
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Finnish

Kolmen viikon sapropteriinidihydrokloridihoidon jälkeen annoksella 20 mg/ kg/ vrk veren fenyylialaniinitasot olivat laskeneet merkitsevästi; keskiarvoinen ± SD veren fenyylialaniinitason lasku lähtötilanteesta oli tässä ryhmässä 148, 5 µmol/ l ± 134, 2 µmol/ l (p < 0, 001).

English

After 3 weeks of treatment with sapropterin dihydrochloride 20 mg/ kg/ day, blood phenylalanine levels were significantly reduced; the mean ± SD decrease from baseline in blood phenylalanine level within this group was 148.5 ±134.2 μ mol/ l (p < 0.001).

Last Update: 2012-04-10
Usage Frequency: 1
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Finnish

Erillisessä 10 viikkoa kestäneessä plasebo- kontrolloidussa tutkimuksessa 45 PKU- potilasta, joiden veren fenyylialaniinitasoja kontrolloitiin vakiintuneella fenyylialaniinin suhteen rajoitetulla ruokavaliolla (veren fenyylialaniini ≤480 µmol/ l tutkimukseen mukaantulovaiheessa), satunnaistettiin 3: 1 sapropteriinidihydrokloridihoidolle 20 mg/ kg/ vrk (n=33) tai plasebolle (n=12).

English

In a separate 10-week, placebo-controlled study, 45 PKU patients with blood phenylalanine levels controlled on a stable phenylalanine-restricted diet (blood phenylalanine ≤ 480 μ mol/ l on enrolment) were randomized 3:1 to treatment with sapropterin dihydrochloride 20 mg/ kg/ day (n=33) or placebo (n=12).

Last Update: 2012-04-10
Usage Frequency: 1
Quality:

Finnish

Sapropteriinihoitoa saaneiden ryhmässä keskiarvoinen ± SD ravinnon mukana tulevan fenyylialaniinin siedettävyys oli 38, 406 ± 21, 606 mg/ kg/ vrk sapropteriinidihydrokloridihoidon aikana annoksella 20 mg/ kg/ vrk, verrattuna 15, 660 ± 7, 159 mg/ kg/ vrk ennen hoidon aloitusta.

English

For the sapropterin treatment group, the mean ± SD total dietary phenylalanine tolerance was 38.406 ± 21.606 mg/ kg/ day during treatment with sapropterin dihydrochloride 20 mg/ kg/ day compared to 15.660 ± 7.159 mg/ kg/ day before treatment.

Last Update: 2012-04-10
Usage Frequency: 1
Quality:

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