Results for tributylalkylphosphonium translation from French to English

la présente invention concerne l'utilisation telle que définie ci-dessus, pour la mise en œuvre de la réaction de baylis-hilman, selon le schéma réactionnel suivant : estérifi cation y-l-f 0 , x,- l clivage par transestérifi cation ou transamidation y-l-f 0 , x 2 - + g y-l-f ! , x; hquide ionique aι + xf hquide ionique réaction de suzuki xr avec r 2 χ clivage par trans estérification hquide ionique vxf y 4" -, l, x 2 ~ , et r 2 étant tels que définis ci-dessus, les fonctions f 0 , fi et f 2 étant telles que définies ci-dessous : - f 0 est de la forme -χih, χi étant tel que défini ci-dessus, - fi est de la forme -r q -b(or 7 ) 2 , r 7 étant tel que défini ci-dessus, et r q correspondant à un groupe aryle comprenant de 6 à 30 atomes de carbone, hétéroaryle comprenant de 4 à 20 atomes de carbone, éthényle comprenant de 2 à 20 atomes de carbone, diényle comprenant de 3 à 20 atomes de carbone, allyle comprenant de 3 à 20 atomes de carbone, éthynyle comprenant de 2 à 20 atomes de carbone, substitués ou non, f \ répondant de préférence à la formule suivante : ar 2 correspondant à un groupe aryle substitué ou non comprenant de 6 à 30 atomes de carbone, - f 2 est de la forme -rq-r», rq et r» étant tels que définis ci-dessus, f 2 répondant de préférence à la formule suivante : ari représentant un groupe aromatique choisi de préférence parmi la molécule g étant de la forme r 2 -r 3 , r 2 et r 3 étant tels que définis ci-dessus, et répondant notamment à la formule suivante : dans laquelle , ari et ar 2 sont tels que définis ci-dessus, réaction de avec chvage par liquide ionique suzuki transestérification i + xi- r, ou transamidation y + -, l, x 2 , ai^xi , r 2 et r 3 étant tels que définis ci-dessus, r 3 étant de préférence un groupe phényle, a 2 , br 7 r 6 x 2 x + r^-r g a 2 + étant un cation ammonium (r a )3n " ou phosphonium (r a ) 3 p + rb, de préférence tétrabutylammonium et tétraméthylammonium, r a et r b étant tels que définis ci-dessus, x 2 ~~ étant notamment choisi parmi oh " , f "" , cn ~ , r s o ~" , r s s ~ de préférence oh " ou f " , r s représentant un groupe alkyle comprenant de 1 à 20 atomes de carbone ou un groupe aryle comprenant de 6 à 30 atomes de carbone, r 3 et r 4 étant tels que définis ci-dessus, rg et r 7 représentant indépendamment l'un de l'autre un groupe alkyle . comprenant de 1 à 20 atomes de carbone ou un groupe aryle comprenant de 6 à 30 atomes de carbone, la molécule borée de formule r 3 r 7 reb étant un trialkyle ou aryle borane, le groupe alkyle comprenant de 1 à 20 atomes de carbone et le groupe aryle comprenant de 6 à 30 atomes de carbone, un acide ou ester borinique, de préférence un acide ou ester boronique choisi comme étant l'acide phényl boronique, r 2 et χ sont tels que définis précédemment, r 2 χ correspondant de préférence à un halogénure d' aryle choisi parmi : la présente invention concerne également l'utilisation telle que définie ci-dessus, pour la synthèse de banques de molécules selon la technique de synthèse parallèle, selon le schéma suivant : liquide ionique y-l-f 0 , x 2 - al+xf > y-l-f, , x,- caractérisée en ce que le sel fonctionnalisé y + -l-f l5 x 2 " dans le liquide ionique ai + , xf est séparé en n parties sensiblement égales, n variant de 2 à 1024, et en ce que chacune de ces parties est ensuite transformée selon une réaction de synthèse organique, de préférence une réaction de couplage de heck ou de suzuki, à l'aide chacune d'un réactif différent b; pour donner n solutions contenant chacune un composé défini y + -l-f 2 1 , x 2 _ , f 2 1 représentant une fonction choisie parmi les fonctions telles que définies ci-dessus, i variant de 1 à n, chaque solution étant traitée pour libérer les molécules gi, i variant de 1 à n, qui sont chacune isolées et purifiées, constituant une banque de molécules.
the present invention relates to the use as defined above, for implementation of the baylis-hillman reaction, according to the following reaction diagram: y + — representing an onium cation as defined above, and preferably being a trimethylalkylammonium, triethylalkylammonium or tributylalkylphosphonium cation, l representing an arm, in particular a linear or branched alkyl group comprising 1 to 20 carbon atoms, or an optionally functional aralkyl group, comprising 6 to 30 carbon atoms, and preferably being a linear alkyl group preferably a linear alkyl group of (ch2) r type, r varying from 1 to 20, and preferably from 3 to 6, x 2 − being as defined above, and being in particular bf 4 − , pf 6 − , ntf 2 − , cf 3 so 3 − , cl − , br − , i − , ch 3 co 2 − or cf 3 co 2 − , the a 1 + x 1 − ionic liquid being in particular in the form: r a and r b being as defined above, and preferably representing alkyl groups comprising 1 to 20 carbon atoms, x 1 − being chosen from: bf 4 − , pf 6 − , ntf 2 − , cl − , br − , ch 3 coo − , cf 3 co 2 − , cf 3 so 3 − , br 4 − , r being as defined above, the functions f 0 , f 1 and f 2 being as defined below: f 0 represents an —oh group, f 1 corresponds to the following formula: f 2 corresponds to the following formula: g corresponding to the following formula: χ 1 representing an —oh group, or an —or g group, r g representing a linear or branched alkyl group, comprising 1 to 20 carbon atoms, ar representing a substituted or non-substituted, aromatic or heteroaromatic group archo being in particular chosen from: the present invention relates to use as defined above, for implementation of suzuki coupling, according to one of the following reaction diagrams: r 3 being chosen from the substituted or non-substituted aryl, heteroaryl, ethenyl, dienyl, allyl, ethynyl groups, comprising 2 to 30 carbon atoms, r 7 represents a branched or linear alkyl group or a cycloalkyl group comprising 1 to 12 carbon atoms, y + — representing an onium cation as defined above, and preferably being a trimethylalkylammonium, triethylalkylammonium or tributylalkylphosphonium cation, l representing an arm, in particular a linear or branched alkyl group comprising 1 to 20 carbon atoms, or an optionally functional aralkyl group comprising 6 to 30 carbon atoms, and preferably being a linear alkyl group, preferably a linear alkyl group of (ch 2 ) r type, r varying from 2 to 20, and preferably from 3 to 6, x 2 − being as defined above, and being in particular ntf 2 − , bf 4 − , pf 6 − , cl − , br − , ch 3 coo − , cf 3 co 2 − , cf 3 so 3 − , br 4 − , r being as defined above, the a 1 + x 1 − ionic liquid being in particular in the form: r a and r b being as defined above, and preferably representing alkyl groups comprising 1 to 20 carbon atoms, x 1 − being chosen from: bf 4 − , pf 6 − , ntf 2 − , cl − , br − , ch 3 coo − , cf 3 co 2 − , cf 3 so 3 − , br 4 − , r being as defined above, the functions f 0 , f 1 and f 2 being as defined below: f 0 is in the form −χ 1 h, χ 1 representing an oxygen atom or an —nr f group, r f corresponding to a linear or branched alkyl group, comprising 1 to 20 carbon atoms, or an aryl group comprising 6 to 30 carbon atoms, f 1 is in the form —r e χ, r e representing an aromatic or heteroaromatic group comprising 6 to 30 carbon atoms, χ representing a leaving group preferably chosen from cl, br, i, otf, o—co 2 r 5 or oso 3 —r 5 , r 5 representing an alkyl group comprising 1 to 10 carbon atoms or an aralkyl group comprising 6 to 30 carbon atoms, f 1 preferably corresponding to the following formula: f 2 is in the form —r e —r 2 , r e being as defined above and r 2 being chosen from the substituted or non-substituted aryl, heteroaryl, ethenyl, dienyl, allyl, ethynyl groups, comprising 2 to 30 carbon atoms, f 2 preferably corresponding to the following formula: ar 1 representing an aromatic group preferably chosen from: the g molecule being in the form r 2 —r 3 , r 2 and r 3 being as defined above, and corresponds in particular to the following formula: in which χ 2 represents either an —or g group, r g representing a hydrogen atom or an alkyl group comprising 1 to 20 carbon atoms, or an —nr h r u group, r h and r u representing independently of one another a hydrogen atom, an alkyl group comprising 1 to 20 carbon atoms or an aryl group comprising 6 to 30 carbon atoms, ar 1 is as defined above, y + —, l, x 2 − , a 1 +x 1 − and r 2 being as defined above, the functions f 0 , f 1 and f 2 being as defined below: f 0 is in the form −χ 1 h, χ 1 being as defined above, f 1 is in the form —r q —b(or 7 ) 2 , r 7 being as defined above, and r q corresponding to a substituted or non-substituted aryl group comprising 6 to 30 carbon atoms, heteroaryl group comprising 4 to 20 carbon atoms, ethenyl group comprising 2 to 20 carbon atoms, dienyl group comprising 3 to 20 carbon atoms, allyl group comprising 3 to 20 carbon atoms, ethynyl group comprising 2 to 20 carbon atoms, f 1 preferably corresponding to the following formula: ar 2 corresponding to a substituted or non-substituted aryl group comprising 6 to 30 carbon atoms, f 2 is in the form —r q —r e , r q and r e being as defined above, f 2 preferably corresponding to the following formula: ar 1 representing an aromatic group preferably chosen from: the g molecule being in the form r 2 —r 3 , r 2 and r 3 being as defined above, and corresponding in particular to the following formula: in which χ 2 , ar 1 and ar 2 are as defined above, y + —, l, x 2 − , a 1 + x 1 − , r 2 and r 3 being as defined above, r 3 preferably being a phenyl group, a 2 + being an (r a ) 3 n + r b ammonium or (r a ) 3 p + r b phosphonium cation, preferably tetrabutylammonium and tetramethylammonium, r a and r b being as defined above, x 2 − being in particular chosen from oh − , f − , cn − , ro − , rs − , preferably oh − or f − , r s representing an alkyl group comprising 1 to 20 carbon atoms or an aryl group comprising 6 to 30 carbon atoms, r 3 and r 4 being as defined above, r 6 and r 7 representing independently of one another an alkyl group comprising 1 to 20 carbon atoms or an aryl group comprising 6 to 30 carbon atoms, the boronic molecule of formula r 3 r 7 r 6 b being a trialkyl or aryl borane, the alkyl group comprising 1 to 20 carbon atoms and the aryl group comprising 6 to 30 carbon atoms, a boronic acid or ester, preferably a boronic acid or ester chosen as being phenyl boronic acid, r 2 and χ are as previously defined, r 2 χ preferably corresponding to an aryl halide chosen from: the present invention also relates to the use as defined above, for the synthesis of libraries of molecules according to the parallel-synthesis technique, according to the following diagram: characterized in that the y + -l-f 1 , x 2 − functionalized salt in the a 1 + , x 1 − ionic liquid is separated into n approximately equal parts, n varying from 2 to 1024, and in that each of these parts is then converted according to an organic-synthesis reaction, preferably a heck or suzuki coupling reaction, each using a different reagent b i in order to produce n solutions each containing a defined y + -l-f 2 i , x 2 − compound, f 2 i representing a function chosen from the functions as defined above, i varying from 1 to n, each solution being treated in order to release the g i molecules, i varying from 1 to n, which are each isolated and purified, constituting a molecule library.