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Results for vismodegib translation from Slovak to English

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Slovak

Liečivo je vismodegib.

English

The active substance is vismodegib.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Vismodegib je prítomný v semene.

English

Vismodegib is present in semen.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Erivedge 150 mg tvrdé kapsuly vismodegib

English

Erivedge 150 mg hard capsules vismodegib

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

In vitro je vismodegib inhibítorom OATP1B1.

English

In vitro, vismodegib is an inhibitor of OATP1B1.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Účinky súbežne podávaných liekov na vismodegib

English

Effects of concomitant medicinal products on vismodegib

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Je to liek na rakovinu a obsahuje liečivo vismodegib.

English

Erivedge is an anti-cancer medicine and contains the active substance vismodegib.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Perorálne podaný vismodegib sa obličkami vylučuje v malej miere.

English

Renal excretion of orally administered vismodegib is low.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Erivedge je protirakovinový liek, ktorý obsahuje účinnú látku vismodegib.

English

Erivedge is a cancer medicine that contains the active substance vismodegib.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Vismodegib sa pomaly eliminuje kombináciou metabolizmu a exkrécie východiskového liečiva.

English

Vismodegib is slowly eliminated by a combination of metabolism and excretion of parent drug substance.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Nie je známe, do akej miery sa vismodegib vylučuje do materského mlieka.

English

The extent to which vismodegib is excreted in breast milk is not known.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Vismodegib a s ním spojené metabolické produkty sa eliminujú predovšetkým prostredníctvom pečene.

English

Vismodegib and associated metabolic products are eliminated primarily by the hepatic route.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Vismodegib sa viaže a inhibuje SMO proteín, a tým zabraňuje transdukcii signálu Hedgehog.

English

Vismodegib binds to and inhibits the SMO protein thereby blocking Hedgehog signal transduction.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Nevyhnutná je opatrnosť najmä, ak je vismodegib podávaný v kombinácii s akýmkoľvek statínom.

English

In particular, caution should be exercised if vismodegib is administered in combination with any statin.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Vismodegib inhibuje UGT2B7 in vitro a nie je možné vylúčiť, že inhibícia sa odohráva aj in vivo v čreve.

English

Vismodegib inhibits UGT2B7 in vitro and it may not be excluded that inhibition can take place in vivo in the intestine.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Naviazaním na bielkovinu SMO vismodegib blokuje túto dráhu, a tak spomaľuje rast a šírenie rakovinových buniek bazocelulárneho karcinómu.

English

By attaching to SMO, vismodegib blocks this pathway, thereby slowing down the growth and spread of the cancer cells in basal cell carcinoma.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Avšak interakčná štúdia trvala len 7 dní a nie je možné vylúčiť, že vismodegib po dlhšej liečbe je induktor enzýmov, ktoré metabolizujú kontraceptívne steroidy.

English

However, the interaction study was of only 7 days duration and it cannot be excluded that vismodegib upon longer treatment is an inducer of enzymes which metabolise contraceptive steroids.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Nie je možné vylúčiť, že vismodegib môže zapríčiniť zvýšenú expozíciu liečiv transportovaných týmto proteínom, ako je rosuvastatín, topotekán a sulfasalazín.

English

It may not be excluded that vismodegib may give rise to increased exposure of medicinal products transported by this protein, such as rosuvastatin, topotecan, and sulfasalazin.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Preto so zreteľom na údaje posúdené v PSURe, PRAC zvážil, že zmeny týkajúce sa informácii o lieku a podmienok registrácie liekov obsahujúcich vismodegib sú opodstatnené.

English

Therefore, in view of the data presented in the reviewed PSUR, the PRAC considered that changes to the product information and conditions of the marketing authorisation of medicinal products containing vismodegib were warranted.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

V štúdii embryofetálneho vývoja, v ktorom sa gravidným potkanom podával denne vismodegib v priebehu organogenézy, vismodegib prechádzal placentou a bol závažne toxický pre zárodok.

English

In an embryo-foetal development study in which pregnant rats were administered vismodegib daily during organogenesis, vismodegib crossed the placenta and was severely toxic to the conceptus.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

Slovak

Účinná látka lieku Erivedge, vismodegib, prerušuje takzvanú signálnu Hedgehog dráhu, ktorá sa za normálnych okolností podieľa na regulácii prvých štádií vývoja buniek u nenarodených detí a na

English

The active substance in Erivedge, vismodegib, disrupts the so-called ‘Hedgehog signalling pathway’, which is normally involved in regulating the early stages of cell development in unborn babies and certain cell processes in adults.

Last Update: 2017-04-26
Usage Frequency: 1
Quality:

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