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væsentlige biotransformationer hos hunde inkluderer hydroxylering, konjugering med glukoronsyre og n-methylering i leveren.
major biotransformations in the dog include hydroxylation, glucuronic acid conjugation and n- methylation in the liver.
den aktive metabolit metaboliseres yderligere i to inaktive forbindelser ved s - methylering eller konjugering med cystein.
the active metabolite is further metabolised to two inactive compounds by s- methylation or conjugation with cysteine.
ved homocystinuri nedsætter betain homocysteinindholdet i blodet ved at fremme en reaktion, der kaldes methylering, hvorved homocystein tilbagedannes til methionin.
in homocystinuria, betaine reduces homocysteine levels in the blood by facilitating a reaction in the body called ‘methylation’, which converts homocysteine back into methionine.
der findes tre typer af initial metaboliske reaktioner, direkte n-glukuronidering, direkte n-methylering og cytochrom p450 katalyseret oxidation.
there are three types of initial metabolic reactions; direct n-glucuronidation, direct n-methylation and cytochrome p450 catalysed oxidation.
levodopa metaboliseres i høj grad til forskellige metabolitter, hvor decarboxylering via dopadecarboxylase (ddc) og o- methylering via cathecol- o- methyltransferase (comt) er de vigtigste metaboliseringsveje.
levodopa is extensively metabolised to various metabolites, decarboxylation by dopa decarboxylase (ddc) and o-methylation by catechol-o-methyltransferase (comt) being the most important pathways.