Usted buscó: mtic (Danés - Inglés)

i kroppen omdannes temozolomid til et andet stof, mtic.
in the body, temozolomide is converted to another compound, mtic.

in vivo var t1/2 for mtic 1, 8 timer som for temozolomid.
in vivo, the t1/2 of mtic was similar to that of temozolomide, 1.8 hr.

temozolomid er et triazen, der hurtigt omdannes kemisk ved fysiologisk ph til det aktive stof mtic.
temozolomide is a triazene, which undergoes rapid chemical conversion at physiologic ph to the active compound mtic.

gennemsnits auc- værdier (0 → ∞) for tmz og mtic var henholdsvis 25 µg
mean auc (0 → ∞) values for tmz and mtic were 25 µg

cmax og auc for tmz og mtic sammenlignet med temodal hårde kapsler efterfulgt af en indgift på 150 mg/ m2.
in an open-label, two-way crossover bioequivalence study of the pharmacokinetics of oral and intravenous tmz in patients with primary cns malignancies, temodal 2.5 mg/ml powder for solution for infusion administered over 90 minutes was found to be bioequivalent for cmax and auc of tmz and mtic as compared to temodal hard capsules, following administration of 150 mg/m2 dose.

mtic binder sig til dna’et i cellerne, mens disse reproducerer sig selv, hvorved celledelingen standses.
mtic binds to the dna of cells while they are reproducing, which stops cell division.

i forhold til auc af tmz er eksponeringen til mtic og aic henholdsvis ~ 2,4 % og 23 %.
relative to the auc of tmz, the exposure to mtic and aic is ~ 2.4 % and 23 %, respectively.

indtagelse af temodal sammen med ranitidin resulterede ikke i ændringer i absorptionsgraden af temozolomid eller eksponeringen til monomethyltriazenoimidazolcarboxamid (mtic) .
administration of temodal with ranitidine did not result in alterations in the extent of absorption of temozolomide or the exposure to monomethyl triazenoimidazole carboxamide (mtic) .

mtics cytotoksiske effekt formodes primært at skyldes alkyleringen ved o6-positionen i guanin med ledsagende alkylering ved n7-positionen.
the cytotoxicity of mtic is thought to be due primarily to alkylation at the o6 position of guanine with additional alkylation also occurring at the n7 position.