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the subacute toxicity of a cn mixture and its effect on cytochrome p-450 levels in rats was investigated by kilanowicz and skrzypinska-gawrysiak (2010).
kilanowicz和skrzypinska-gawrysiak(2010年)研究了氯化萘混合物的亚急性毒性及其对大鼠体内细胞色素p-450水平的影响。
formation of this metabolite is mediated by cytochrome p450 3a monooxygenases, which are expressed only in male rats (birner et al., 1995; werner et al., 1995a).
细胞色素p450 3a单氧酶是形成这一代谢物的中介物质,该物质仅在雄性大鼠体内分泌(birner等人,1995年;werner等人,1995a)。
chlordecone is not genotoxic in in vitro microbial and mammalian cell gene mutation assays, in a clastogenicity test and in the dominant lethal assay (mortelmans et. al., 1986; probst et. al., 1981; schoeny et. al., 1979, tong et. al. 1981; williams 1980, khera et. al., 1976; simon et. al., 1986, as reported in atsdr (1995), although it has been reported to interfere with cell-to-cell communication (tsushimoto et. al., 1982, caldwell and loch-caruso, 1992, as reported in us atsdr (1995), suggests that it produces liver tumours by an epigenetic, tumour-promoting mechanism involving both hepatic toxicity and hypertrophy, including cytochrome p-450 induction.
十氯酮在体外微生物及哺乳动物细胞基因变异试验、染色体畸形试验及显性致死试验中不具基因毒性(mortelmans 等人,1986年;probst 等人,1981年;schoeny 等人,1979年;tong 等人,1981年;williams,1980年;khera 等人,1976年;simon 等人,1986年;援引美国毒物和疾病登记署报告,1995年),虽然人们发现它会干扰细胞间的信息传递(tsushimoto等人,1982年;caldwell和loch-caruso,1992年;援引美国毒物和疾病登记署报告,1995年)。