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destructive regime
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complement has evolved as a major defence against infection, evident by the fact that many microorganisms including bacteria and viruses have developed resistance to complement and can exploit the complement system to facilitate tissue invasion (reviewed in agrawal et al, 2017). the inflammatory response to infection mediated by complement may also be tissue-destructive and contribute to the clinical syndrome of sepsis (reviewed by rittirsch et al, 2008) and multiorgan failure (mof) (reviewed by rittirsch et al, 2012). a tipping point occurs where the harmful effects of complement in the response to infection may outweigh the beneficial effects. this is highly pertinent in covid-19 infection, in which the highest mortality is evident in patients with severe pneu- monitis, systemic sepsis and mof (li et al, 2020; poston et al, 2020) and where evidence of profound complement activation is beginning to emerge. the aim of this review is to summarise current understanding of the interaction of sars-cov-2 virus with the complement system and examine the case for targeting the inflammatory reaction mediated by complement in severe covid-19 disease. since complement is a compartmentalised component of innate immunity, this review will take into account the local synthe- sis of complement components at the portal of viral invasion, as well as the circulating pool. necessarily, the review will focus on the recent literature, albeit fragmentary, and draw inference from the larger body of published work on other coronavirus pathogens.
titik kritis terjadi di mana efek berbahaya dari komplemen dalam menanggapi infeksi mungkin lebih besar daripada efek menguntungkannya. hal ini sangat terkait dengan infeksi covid 19, di mana kematian tertinggi terlihat pada pasien dengan pneu monitis berat, sepsis sistemik dan mof (li et al, 2020; poston et al, 2020) dan di mana bukti aktivasi komplemen yang mendalam mulai muncul. tujuan dari ulasan ini adalah untuk merangkum pemahaman terkini tentang interaksi kecerd