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mechanisms of resistance bacterial resistance mechanisms that effect doripenem include active substance inactivation by carbapenem-hydrolyzing enzymes, mutant or acquired pbp’s, decreased outer membrane permeability and active efflux.
mecanisme de rezistenţă mecanismele rezistenţei bacteriene care afectează doripenemul cuprind inactivarea substanţei active de către enzimele ce hidrolizează carbapenemul, plep mutante sau dobândite, scăderea permeabilităţii membranei externe şi efluxul activ.

doripenem is stable to hydrolysis by most beta-lactamases, including penicillinases and cephalosporinases produced by gram-positive and gram-negative bacteria, with the exception of relatively rare carbapenem hydrolyzing beta-lactamases.
doripenemul este stabil la hidroliza celor mai multe beta- lactamaze, inclusiv penicilinazele şi cefalosporinazele produse de bacteriile gram- pozitive şi gram- negative, cu excepţia beta- lactamazelor capabile să hidrolizeze carbepenemii, relativ rare.