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Roumain

Anglais

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Roumain

Dasatinib are potenţial fototoxic observat in vitro prin test de fototoxicitate cu absorbţie în lumina roşie neutră pe fibroblaştii de şoarece.

Anglais

Dasatinib had phototoxic potential in an in vitro neutral red uptake phototoxicity assay in mouse fibroblasts.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 3
Qualité :

Roumain

Factorul de stimulare a coloniilor granulocitare bovine este o proteină naturală, produsă de leucocitele mononucleare, celulele endoteliale şi fibroblaşti.

Anglais

Bovine granulocyte colony stimulating factor is a naturally occurring protein produced by mononuclear leukocytes, endothelial cells and fibroblasts.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

2 produs în fibroblaşti pulmonari umani diploizi WI-38.

Anglais

2 produced in WI-38 human diploid lung fibroblasts.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 3
Qualité :

Roumain

In vitro, după iradierea UVA a culturilor de fibroblaşti murinici, vemurafenib s-a dovedit să fie fototoxic, dar nu şi in vivo într-un studiu la şobolan în doze de până la 450 mg/kg şi zi (la expuneri sub expunerea clinică anticipată pe baza comparaţiilor ASC).

Anglais

Vemurafenib was shown to be phototoxic, in vitro, on cultured murine fibroblasts after UVA irradiation, but not in vivo in a rat study at doses up to 450 mg/kg/day (at exposures below the anticipated clinical exposure (based on AUC comparison).

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

În testele in vitro pe limfocite umane cu activitate trifosforilantă (la care nu s-a stabilit valoarea fără efect), pe fibroblaştii de şoarece şi într-un test in vivo pentru aberaţii cromozomiale, stavudina a fost genotoxică.

Anglais

Stavudine was genotoxic in in vitro tests in human lymphocytes possessing triphosphorylating activity (in which no no-effect level was established), in mouse fibroblasts, and in an in vivo test for chromosomal aberrations.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 3
Qualité :

Roumain

Evaluarea potențialului idelalisibului de a determina fototoxicitate la nivelul liniilor celulare de fibroblaşti embrionari murini BALB/c 3T3 nu a fost concludentă, din cauza citotoxicității observate la testele in vitro.

Anglais

Evaluation of the potential for phototoxicity in the embryonic murine fibroblast cell line BALB/c 3T3 was inconclusive for idelalisib due to cytotoxicity in the in vitro assay.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Lenvatinib este un inhibitor al receptorilor tirozin kinazei (RTK) care inhibă selectiv activităţile kinazice ale receptorilor factorului de creştere a endoteliului vascular (FCEV), RFCEV1 (FLT1), RFCEV2 (KDR) şi RFCEV3 (FLT4), în plus faţă de alţi RTK legaţi de căile proangiogene şi oncogene, inclusiv receptorii factorului de creştere a fibroblaştilor (FCF) RFCF1, 2, 3, şi 4, receptorul factorului de creştere derivat din plachete sangvine (FCDP) RFCDPα, KIT şi RET.

Anglais

Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4), in addition to other proangiogenic and oncogenic pathway-related RTKs including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4, the platelet derived growth factor (PDGF) receptor PDGFRα, KIT, and RET.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Factorul de stimulare al coloniilor granulocitare bovine este o proteină naturală, produsă de leucocitele mononucleare, celulele endoteliale şi fibroblaşti.

Anglais

Bovine granulocyte colony stimulating factor is a naturally occurring protein produced by mononuclear leukocytes, endothelial cells and fibroblasts.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Nintedanib inhibă activarea cascadelor de semnalizare ale FGFR and PDGFR, implicate în mod critic în proliferarea, migrarea şi diferenţierea fibroblaştilor/miofibroblaştilor pulmonari, celule caracteristice în patologia fibrozei pulmonare idiopatice.

Anglais

Nintedanib inhibits the activation of FGFR and PDGFR signalling cascades which are critically involved in proliferation, migration and differentiation of lung fibroblasts/myofibroblasts, the hallmark cells in the pathology of idiopathic pulmonary fibrosis.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Everolimus este un inhibitor puternic al creşterii şi proliferării celulelor tumorale, celulelor endoteliate, fibroblaştilor şi celulelor musculare netede ale vaselor de sânge şi s-a dovedit că reduce glicoliza în tumorile solide in vitro şi in vivo.

Anglais

Everolimus is a potent inhibitor of the growth and proliferation of tumour cells, endothelial cells, fibroblasts and blood-vessel-associated smooth muscle cells and has been shown to reduce glycolysis in solid tumours in vitro and in vivo.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

IL-6 este o citokină proinflamatorie pleiotropă, produsă de o varietate de tipuri de celule, incluzând celulele T şi B, monocite şi fibroblaşti.

Anglais

IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T- and B-cells, monocytes and fibroblasts.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Everolimus este un puternic inhibitor al creşterii şi proliferării celulelor tumorale, celulelor endoteliate, fibroblaştilor şi celulelor musculare netede ale vaselor de sânge şi s-a dovedit că reduce glicoliza în tumorile solide in vitro şi in vivo.

Anglais

Everolimus is a potent inhibitor of the growth and proliferation of tumour cells, endothelial cells, fibroblasts and blood-vessel-associated smooth muscle cells and has been shown to reduce glycolysis in solid tumours in vitro and in vivo.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Interferonul beta este produs de diferite tipuri de celule, inclusiv fibroblaşti şi macrofage.

Anglais

Interferon beta is produced by various cell types including fibroblasts and macrophages.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 3
Qualité :

Roumain

Mecanismul de acţiune al pirfenidonei, substanţa activă din Esbriet, nu este pe deplin înţeles, dar s-a demonstrat că reduce producţia de fibroblaşti şi alte substanţe implicate în formarea ţesutului fibros dur în timpul procesului de reparare tisulară al organismului, încetinind astfel progresia bolii la pacienţii cu FPI.

Anglais

The mechanism of action of pirfenidone, the active substance in Esbriet, is not fully understood, but it has been shown to reduce the production of fibroblasts and other substances involved in the formation of hard fibrous tissue during the body’s tissue repair process, thereby slowing down the progression of the disease in IPF patients.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

Toţi cei trei metaboliţi au prezentat activitate care a fost ≤ 5% din cea a bosutinib la testul de evaluare a creşterii independente de ancoraj a fibroblaştilor transformaţi de Src.

Anglais

All three metabolites exhibited activity that was  5% that of bosutinib in a Src-transformed fibroblast anchorage-independent proliferation assay.

Dernière mise à jour : 2017-04-26
Fréquence d'utilisation : 1
Qualité :

Roumain

(2) produs în fibroblaşti pulmonari umani diploizi (WI- 38).

Anglais

(2) Produced in human diploid lung (WI-38) fibroblasts.

Dernière mise à jour : 2012-04-11
Fréquence d'utilisation : 4
Qualité :

Roumain

(2) Produs în fibroblaşti pulmonari umani diploizi (WI- 38).

Anglais

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Dernière mise à jour : 2011-10-23
Fréquence d'utilisation : 1
Qualité :

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