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seda toodab teatav pärm, millesse on viidud detemirinsuliini moodustumist võimaldav geen (dna).
insulin detemir is very slightly different from human insulin, and the change means that it is absorbed more slowly by the body, and takes longer to reach its target in the body.
in vitro katsetes on posakonasool näidanud fungitsiidset aktiivsust enamuse kontrollitud umbes 7000 pärm- ja filamentoosse seene tüve suhtes.
in in vitro tests, posaconazole has shown fungicidal activity against most of the approximately 7,000 strains of yeast and filamentous fungi tested.
posakonasooli fungitsiidse toime mehhanism hõlmab ensüüm lanosterooli 14-demetülaasi (cyp51) inhibeerimist, mis osaleb ergosterooli biosünteesis pärm- ja filamentoossetes seentes.
the mechanism by which posaconazole exerts fungicidal action involves the selective inhibition of the enzyme lanosterol 14-demethylase (cyp51) involved in ergosterol biosynthesis in yeasts and filamentous fungi.