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ippolita was alfons' eerste echtgenote.
the marriage of alfonso and ippolita was politically advantageous as it created a powerful alliance between the kingdom of naples and the duchy of milan, which was one of the most important of the 15th century italian city-states.
alfons zou later kort regeren als koning alfons ii van napels.
==marriage and issue==on 10 october 1465, in milan, ippolita, aged nineteen, married alfonso, duke of calabria (4 november 1448 – 18 december 1495), the eldest son of king ferdinand i of naples and isabella of clermont, duchess of calabria.