검색어: dosisproportionaliteten (덴마크어 - 영어)

dosisproportionaliteten vistes i enkelt- og flerdosisstudierne.
dose proportionality was demonstrated in the single and multiple dose studies.

den systemiske eksponering for stiripentol stiger markant sammenlignet med dosisproportionaliteten.
systemic exposure to stiripentol increases markedly compared to dose proportionality.

- dosisområdet for rapinyl og dosisproportionaliteten mellem actiq og rapinyl blev anset som
- the dose range of rapinyl and the dose proportionalilty between actiq and rapinyl was considered

dosisproportionaliteten er ikke blevet evalueret formelt, men der er ingen klar mætning for clearance på tværs af dosisområdet.
dose proportionality has not been formally evaluated, but there is no apparent saturation of clearance across the dosing range.

dosisproportionaliteten blev ikke fastslået for cmax og c24t (cmax steg mere end dosisproportionalt og c24t steg mindre end dosisproportionalt).
dose-proportionality was not established for cmax and c24hr (cmax increased in a greater than dose-proportional manner and c24hr increased in a less than dose-proportional manner).

dosisproportionaliteten blev ikke fastslået for cmax og c24t (cmax øgedes mere end dosisproportionalt og c24t øgedes mindre end dosisproportionalt).
dose-proportionality was not established for cmax and c24hr (cmax increased in a greater than dose-proportional manner and c24hr increased in a less than dose-proportional manner).

dosisproportionaliteten ved eksponering blev fastslået for azilsartan i doseringsintervallet af azilsartan medoxomil fra 20 mg til 320 mg efter en enkelt- dosering eller efter flere doseringer.
dose proportionality in exposure was established for azilsartan in the azilsartan medoxomil dose range of 20 mg to 320 mg after single or multiple dosing.

dosisreduktion af capecitabin nedsætter den systemiske eksponering for 5-fu mere end svarende til dosisproportionaliteten på grund af den aktive metabolits non-lineære farmakokinetik.
capecitabine dose reduction decreases systemic exposure to 5-fu more than dose- proportionally, due to non-linear pharmacokinetics for the active metabolite.

i dosisintervallet 100 mg- 800 mg øgede raltegravir c12 t proportionalt med dosis, men dosisproportionaliteten var lidt mindre end for dosisintervallet 100 mg- 1600 mg.
raltegravir c12 hr increases dose proportionally over the dose range of 100 to 800 mg and increases slightly less than dose proportionally over the dose range 100 mg to 1600 mg.

chmp anså de indgivne oplysninger for at være tilstrækkelige til at konkludere, at data om gentagne doser i forbindelse med actiq og rapinyl er omtrent ens, og dosisproportionaliteten mellem actiq og rapinyl blev anset for at være underbygget via data om enkeltdosis, mens yderligere data om klinisk sikkerhed og effekt afventes.
the chmp considered that the information provided was sufficient for concluding that repeat dose data following actiq and rapinyl are similar, and the dose proportionalilty between actiq and rapinyl was considered as established through the single dose data, pending further clinical safety and efficacy data.

dosisproportionaliteten blev etableret i børn for de undersøgte doser på 90 og 180 µg/ kg kropsvægt, hvilket er i overensstemmelse med tidligere resultater ved lavere doser (17, 5– 70 µg / kg rekombinant faktor viia).
dose proportionality was established in children for the investigated doses of 90 and 180 µg per kg body weight, which is in accordance with previous findings at lower doses (17.5 - 70 µg/ kg rfviia).