검색어: glukuronidacije (슬로베니아어 - 영어)

induktorji glukuronidacije
inducers of glucuronidation

zaradi indukcije glukuronidacije
carbamazepine and

naproksen in drugi zaviralci glukuronidacije
naproxen and other inhibitors of glucuronidation

motnja glukuronidacije, kot je gilbertov sindrom
glucuronidation disorder like gilbert’s syndrome

pri majhnem deležu vitamina d3 pred izločanjem pride do glukuronidacije.
a small percentage of vitamin d3 undergoes glucuronidation prior to elimination.

oksidativni presnovki zdravila se presnavljajo naprej s konjugacijo prek glukuronidacije.
the oxidative metabolites are further metabolised by conjugation via glucuronidation.

bolniki z majhnim izražanjem ugt1a1 ali genetskimi motnjami glukuronidacije (npr.
patients with low expression levels of ugt1a1 or genetic glucuronidation disorders (e.g.

dolutegravir se presnavlja predvsem preko glukuronidacije z ugt1a1 in v majhni meri s cyp3a.
dolutegravir is primarily metabolized through glucuronidation via ugt1a1 with a minor cyp3a component.

pri ljudeh so ugotovili tudi prisotnost metabolitov konjugacij (glukuronidacije in glikozilacije).
conjugation metabolites (glucuronidation and glycosylation) were also identified in humans.

blaga indukcija glukuronidacije je vidna tudi pri 80 mg peroralnem aprepitantu, ki se ga daje 7 dni.
mild induction of glucuronidation is also seen with 80 mg oral aprepitant given for 7 days.

ta režim odmerjanja morate 25 uporabiti z zdravili, ki pomembno ne zavirajo niti ne inducirajo glukuronidacije lamotrigina
25 mg/ day

inhibicija glukuronidacije lahko povzroči interakcije z zdravili, ki so substrati ugt1a1 in se izločajo samo po tej poti.
the inhibition of glucuronidation may cause interactions with medicinal products which are substrates of ugt1a1 and exclusively cleared by this pathway.

v študijah z eslikarbazepinom na svežih hepatocitih človeka so opazili blago aktivacijo glukuronidacije, pri kateri sodeluje ugt1a1.
in studies with eslicarbazepine in fresh human hepatocytes a mild activation of ugt1a1 mediated glucuronidation was observed.

zato se 1-2 tedna po uvedbi zdravljenja z močnimi zaviralci glukuronidacije priporoča nadzor sečne kisline v serumu.
monitoring of serum uric acid is therefore recommended 1-2 weeks after start of treatment with a potent inducer of glucuronidation.

skopi podatki pri bolnikih s cirozo kažejo, da lahko manjši obseg glukuronidacije pri bolnikih z jetrno okvaro privede do kopičenja zidovudina.
limited data in patients with cirrhosis suggest that accumulation of zidovudine may occur in patients with hepatic impairment because of decreased glucuronidation.

erlotinib je močan zaviralec cyp1a1, srednje močan zaviralec cyp3a4 in cyp2c8, kot tudi močan zaviralec glukuronidacije z ugt1a1 in vitro.
erlotinib is a potent inhibitor of cyp1a1, and a moderate inhibitor of cyp3a4 and cyp2c8, as well as a strong inhibitor of glucuronidation by ugt1a1 in vitro.

naproksen in drugi zaviralci glukuronidacije presnova febuksostata je odvisna od encimov uridil- difosfat- glukuroniltransferaze (ugt).
naproxen and other inhibitors of glucuronidation febuxostat metabolism depends on ugt enzymes.

lamotrigin: ob sočasni uporabi kombiniranih hormonskih kontraceptivov z lamotriginom le-ti pomembno zmanjšajo plazemske koncentracije lamotrigina, verjetno zaradi indukcije glukuronidacije lamotrigina.
lamotrigine: combined hormonal contraceptives have been shown to significantly decrease plasma concentrations of lamotrigine when coadministered likely due to induction of lamotrigine glucuronidation.

dodatek induktorjev glukuronidacije lamotrigina pri bolnikih, ki ne jemljejo valproata (glejte poglavje 4. 5), odvisno od prvotnega odmerka lamotrigina:
addition of inducers of lamotrigine glucuronidation in patients not taking valproate (see section 4.5), depending on original dose of lamotrigine:

posakonazol se presnovi prek udp glukuronidacije (encimi 2. faze) in je substrat za odtok p-glikoproteina (p-gp) in vitro.
posaconazole is metabolised via udp glucuronidation (phase 2 enzymes) and is a substrate for p- glycoprotein (p-gp) efflux in vitro.