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inter-subject pharmacokinetic variability for pregabalin is low (< 20%).
la variabilidad farmacocinética interindividual de pregabalina es baja (< 20 %).
마지막 업데이트: 2017-04-26
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the pharmacokinetic profile is linear with low intra- and inter-subject variability.
el perfil farmacocinético es lineal y con poca variabilidad intra- e inter-individual.
마지막 업데이트: 2017-04-26
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larger inter-subject variability was observed in paediatric patients compared to adults.
se observó una mayor variabilidad interindividual en los pacientes pediátricos en comparación con los adultos.
마지막 업데이트: 2017-04-26
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however, due to high inter-subject variability, these differences were not statistically significant.
sin embargo, debido a la elevada variabilidad entre personas, estas diferencias no fueron estadísticamente significativas.
마지막 업데이트: 2017-04-26
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inter-subject variability is high with a cv% of about 50% for cl and 60% for vss
la variabilidad entre sujetos es alta, con un cv% de cerca del 50% para cl y 60% para vss.
마지막 업데이트: 2017-04-26
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the inter-subject variability was large, with a 7-fold difference in unbound auc between patients.
se observó gran variabilidad inter-individual, con una diferencia entre pacientes de 7 veces en el valor de auc libre.
마지막 업데이트: 2012-04-10
사용 빈도: 9
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the pharmacokinetics is dose-proportional and constant over time, with low intra- and inter-subject variability.
la farmacocinética es lineal y constante en el tiempo, con una baja variabilidad intra e intersujetos.
마지막 업데이트: 2017-04-26
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due to the overall inter-subject variability of tasimelteon, this increase is not clinically meaningful and dose adjustment is not recommended.
debido a la variabilidad interindividual global de tasimelteón, este aumento no es clínicamente significativo y no se recomiendan ajustes de la dosis.
마지막 업데이트: 2017-04-26
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treatment, sequence and period were included as fixed effects, intra- and inter subject factors were included as random effects.
el tratamiento, la secuencia y el periodo se incluyeron como efectos fijos y los factores intra- e interindividuales como efectos aleatorios.
마지막 업데이트: 2017-04-26
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inter-subject variability (cv%) for measures of systemic exposures (cmax, auc) was typically approximately 30%.
en las determinaciones de exposición sistémica (cmax, auc) la variabilidad interindividual por lo general fue del 30% aproximadamente.
마지막 업데이트: 2017-04-26
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after oral administration, the apparent volume of distribution of opicapone at a dose of 50 mg was 29 l with an inter-subject variability of 36%.
después de la administración oral, el volumen de distribución aparente de opicapona a una dosis de 50 mg fue de 29 l con una variabilidad entre sujetos del 36%.
마지막 업데이트: 2017-04-26
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inter-subject variability (%cv) for the pk parameters following delivery from evra was higher relative to the variability determined from the oral contraceptive.
15 cmáx para norelgestromina y ee fueron el doble en mujeres a las que se administró el anticonceptivo oral en comparación con evra, mientras que la exposición global (auc y css) fue comparable.
마지막 업데이트: 2008-03-04
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poor bioavailability may lead to an unacceptable dose-form insofar as it is likely to reduce the level of activity significantly or to increase inter-subject fluctuations unacceptably.
inaceptable, puesto que puede llegar a reducir considerablemente el nivel de actividad o aumentar las fluctuaciones de un sujeto a otro de forma inadmisible.
마지막 업데이트: 2014-02-06
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after oral administration, the apparent total body clearance of opicapone at a dose of 50 mg was 22 l/h, with an inter-subject variability of 45%.
después de la administración oral, el aclaramiento corporal total aparente de opicapona a una dosis de 50 mg fue de 22 l/h, con una variabilidad interindividual del 45%.
마지막 업데이트: 2017-04-26
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the predicted oral clearance was 17.7 l/h in women and 22.1 l/h in men, with 39% inter-subject variability in mf patients.
el aclaramiento oral previsto fue de 17,7 l/h en mujeres y 22,1 l/h en hombre, con un 39% de variabilidad inter individual en pacientes con mf.
마지막 업데이트: 2017-04-26
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because of marked inter-subject variability in interferon pharmacokinetics, it is recommended that patients with severe renal impairment be closely monitored during treatment with pegintron (see section 4.2)
dada la marcada variabilidad de la farmacocinética del interferón entre los sujetos, se recomienda controlar estrechamente a los pacientes con insuficiencia renal severa durante el tratamiento con pegintron (ver sección 4.2)
마지막 업데이트: 2011-10-23
사용 빈도: 5
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86. using an inter-subject, subject and comprehensive-education approach, the ministry of education and sports carries out the programmes of education on human and children's rights.
86. aplicando un método interdisciplinario, temático e integral, el ministerio de educación y deportes lleva a cabo varios programas educativos en derechos humanos y del niño.
마지막 업데이트: 2016-11-29
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11 c12hr in benchmrk 1 and 2 the coefficient of variation (cv) for inter-subject variability = 212% and the cv for intra-subject variability = 122%.
para la c12 hr observada en los protocolos 018 y 019, el coeficiente de variación (cv) para la variabilidad interindividual fue = 212% y el cv para la variabilidad intraindividual fue = 122%.
마지막 업데이트: 2008-03-04
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brivaracetam exhibits linear and time-independent pharmacokinetics with low intra- and inter-subject variability, and features complete absorption, very low protein binding, renal excretion following extensive biotransformation, and pharmacologically inactive metabolites.
brivaracetam muestra una farmacocinética lineal e independiente del tiempo con baja variabilidad intra- e inter-sujeto, y presenta una absorción completa, muy baja unión a proteínas, excreción renal tras extensa biotransformación, y metabolitos farmacológicamente inactivos.
마지막 업데이트: 2017-04-26
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pupils learn about human and children' rights through inter-subject integration within the subjects "civic education and ethics ", "geography ", "religions and ethics ", "history " etc., and through subject integration within the subjects "civic education and ethics ", "civic culture " etc.
los alumnos aprenden los derechos del niño mediante la integración disciplinaria de temas como "educación cívica y ética ", "geografía ", "religiones y ética ", "historia ", etc. y el estudio de temas como "educación cívica y ética " o "cultura cívica ".
마지막 업데이트: 2016-11-29
사용 빈도: 1
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