검색어: parp (크로아티아어 - 영어)

bolesnice prethodno nisu smjele biti liječene olaparibom niti drugim inhibitorom parp-a.
patients could not have received prior olaparib or other parp inhibitor treatment.

u replicirajućim stanicama to uzrokuje dvolančane lomove dnk kada replikacijske vilice naiđu na parp-dnk aduktom.
in replicating cells this leads to dna double strand breaks (dsbs) when replication forks meet the parp-dna adduct.

stoga, ako su parp proteini inhibirani, oštećenje dnk u stanica raka ne može se popraviti, i to rezultira smrću stanica raka.
therefore, when parp proteins are blocked, the damaged dna in cancer cells cannot be repaired, and, as a result, the cancer cells die.

djelatna tvar lijeka lynparza, olaparib, inhibira djelovanje enzima naziva humani poli (adp riboza) polimeraza (parp), koji pomaže u popravljanju oštećenja dnk u stanicama (kako u normalnih tako i u stanica raka) tijekom diobe stanica.
the active substance in lynparza, olaparib, blocks the action of enzymes called human poly (adp ribose) polymerase (parp), which help to repair damaged dna in cells (both in normal and in cancer cells) during cell division.