검색어: simvastatinske (크로아티아어 - 영어)

auc simvastatinske kiseline povećao se za 36%, a cmax za približno 100%.
the auc of simvastatin acid was increased by 36% and cmax was increased by approximately 100%.

gemfibrozil povećava auc simvastatinske kiseline za 1,9 puta, vjerojatno zbog inhibicije glukuronidacijskog puta.
gemfibrozil increases the auc of simvastatin acid by 1.9-fold, possibly due to inhibition of the glucuronidation pathway.

primijećeno je smanjenje poluvijeka simvastatina i simvastatinske kiseline sa ~7 sati na 3,5 sati.
a decrease in half- life of simvastatin and simvastatin acid from ~7 hours to 3.5 hours was observed.

ranexa primijenjena u dozi od 1000 mg dvaput dnevno povisila je koncentracije simvastatin laktona u plazmi, simvastatinske kiseline oko 2 puta.
1000 mg twice daily increased plasma concentrations of simvastatin lactone, simvastatin acid by about 2 fold.

primijena lomitapida 60 mg u stanju dinamičke ravnoteže prije simvastatina 40 mg uzrokovala je povećanje auc i cmax simvastatinske kiseline za 68% odnosno 57%.
when lomitapide 60 mg was administered to steady state prior to simvastatin 40 mg, simvastatin acid auc and cmax increased 68% and 57%, respectively.

kada se simvastatin primjenjivao istodobno s lijekom ketek, cmax simvastatina povećao se 5,3 puta, a njegov auc 8,9 puta, dok se cmax simvastatinske kiseline povećao 15 puta, a auc 11 puta.
when simvastatin was coadministered with ketek, there was a 5.3-fold increase in simvastatin cmax, an 8.9-fold increase in simvastatin auc, a 15-fold increase in simvastatin acid cmax and an 11-fold increase in simvastatin acid auc.

kombinacija jedne doze dapagliflozina od 20 mg i simvastatina (supstrata cyp3a4) povećala je auc simvastatina za 19%, a auc simvastatinske kiseline za 31%.
combination of a single dose of dapagliflozin 20 mg and simvastatin (a cyp3a4 substrate) resulted in a 19 % increase in auc of simvastatin and 31 % increase in auc of simvastatin acid.

kombinacija jedne doze dapagliflozina od 20 mg i simvastatina (supstrata cyp3a4) dovela je do povećanja auc-a simvastatina za 19% i povećanja auc-a simvastatinske kiseline za 31%.
combination of a single dose of dapagliflozin 20 mg and simvastatin (a cyp3a4 substrate) resulted in a 19% increase in auc of simvastatin and 31% increase in auc of simvastatin acid.