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persisterende infektion, som varer mindst 6 måneder, er også vist, at være en relevant surrogatmarkør for cervixcancer.
persistent infection that lasts for at least 6 months has also been shown to be a relevant surrogate marker for cervical cancer.
kun testosteronniveauer (dvs. en anerkendt surrogatmarkør for fertilitet) kan med sikkerhed verificere manglende forventet effekt.
only testosterone levels (i.e. an established surrogate marker of fertility) could definitely confirm a lack of efficacy of the treatment.
cervikal intraepitelialneoplasi (cin) grad 2 og 3 blev brugt i de kliniske forsøg som surrogatmarkør for cervix- cancer.
cervical intraepithelial neoplasia (cin) grade 2 and 3 was used in the clinical trials as a surrogate marker for cervical cancer.
ingen af disse to enheder har imidlertid vist sig at være en generel surrogatmarkør for virkning (svr12) ved den terapeutiske dosis på 400 mg.
however, neither of these entities has been evidenced to be a general surrogate marker for efficacy (svr12) at the therapeutic 400 mg dose.
den farmakokinetiske adfærd kan, særlig hvad angår anti- hb - antistoffernes halveringstid og opretholdelsen af et beskyttende niveau af antistoftitre, betragtes som en acceptabel surrogatmarkør for effekt.
the pk behaviour, especially in terms of half life of the anti hb antibodies and maintenance of a protective antibody level titre can be considered as an acceptable surrogate marker of efficacy.
cervikal intraepithelial neoplasi (cin) grade 2/ 3 (moderat til high- grade dysplasi) og adenocarcinoma in situ (ais) blev anvendt i de kliniske undersøgelser som en surrogatmarkør for cervikal cancer.
18 cervical intraepithelial neoplasia (cin) grade 2/ 3 (moderate to high-grade dysplasia) and adenocarcinoma in situ (ais) were used in the clinical trials as a surrogate marker for cervical cancer.