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Engels

temsirolimus has been associated with phospholipidosis in rats.

Kroatisch

temsirolimus je povezan s fosfolipidozom u štakora.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

the significance of phospholipidosis in humans is unknown.

Kroatisch

značaj fosfolipidoze u ljudi nije poznat.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

ultrastructural evidence suggests that these retinal changes may be secondary to phospholipidosis.

Kroatisch

ultrastrukturna analiza upućuje na to da bi promjene na mrežnici mogle biti posljedica fosfolipidoze.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis occurs at acceptable human to animal safety margins and was reversible.

Kroatisch

pojava fosfolipidoze bila je unutar prihvatljivih sigurnosnih margina s obzirom na omjer izloženosti između životinja i ljudi, te je bila reverzibilna.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis in pulmonary macrophages due to accumulation of memantine in lysosomes was observed in rodents.

Kroatisch

kod glodavaca je primijećena fosfolipidoza u plućnim makrofazima zbog nakupljanja memantina u lizosomima.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

pulmonary phospholipidosis resulting in dilatation and obstruction of the alveoli was observed in the 2-year study in rats.

Kroatisch

tijekom dvogodišnjeg ispitivanja u štakora opažena je plućna fosfolipidoza koja je dovela do dilatacije i opstrukcije alveola.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis (vacuolation of the cells of the liver, adrenal gland and lung) also occurred.

Kroatisch

fosfolipidoza (vakuolizacija stanica jetre, nadbubrežne žlijezde i pluća) se pojavila.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis (vacuolation of the cells of the liver, adrenal gland and lung) also occurred.

Kroatisch

fosfolipidoza (vakuolizacija stanica jetre, nadbubrežne žlijezde i pluća) se također pojavila.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis has not been observed in mice or monkeys treated with temsirolimus, nor has it been documented in patients treated with temsirolimus.

Kroatisch

fosfolipidoza nije opažena u miševa ili majmuna liječenih temsirolimusom, niti je zabilježena u bolesnika liječenih temsirolimusom.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

neuronal phospholipidosis occurred in dogs dosed for  3 months at lower systemic exposures than those obtained at therapeutic doses in humans.

Kroatisch

u pasa koji su primali lijek  3 mjeseca razvila se neuronska fosfolipidoza pri manjoj sustavnoj izloženosti od one koja se postiže s terapijskim dozama u ljudi.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 2
Kwaliteit:

Engels

phospholipidosis (foamy macrophages) has been observed with the administration of netupitant after repeated administration in rats and dogs.

Kroatisch

fosfolipidoza (pjenasti makrofazi) opažena je uz primjenu netupitanta nakon ponavljane primjene u štakora i pasa.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

the most important nonclinical safety findings after repeated dosing were the infiltration of macrophages with intracytoplasmic basophilic granular material consistent with phospholipidosis and degenerative lesions in numerous organs and tissues.

Kroatisch

najvažniji neklinički nalazi o sigurnosti primjene ponovljenih doza bili su infiltracija makrofaga intracitoplazmatskim bazofilnim granularnim materijalom sukladno fosfolipidozi i degenerativne lezije u brojnim organima i tkivima.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

of all species, pigment-laden and/or foamy macrophages were also seen in various tissues, consistent with phospholipidosis.

Kroatisch

u mps svih vrsta, sukladno fosfolipidozi, u različitim tkivima uočeni su makrofagi ispunjeni pigmentom i/ili pjenušavi makrofagi.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

in chronic toxicity studies, slight and reversible phospholipidosis (accumulation of foamy macrophages) was observed in mesenteric lymph nodes mainly in the rat.

Kroatisch

u ispitivanjima kronične toksičnosti primijećena je blaga i reverzibilna fosfolipidoza (akumulacija pjenastih makrofaga) u mezenterijskim limfnim čvorovima, uglavnom u štakora.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

although phospholipidosis has not been shown to be a risk for patients administered temsirolimus, it is possible that combined administration of temsirolimus with other amphiphilic agents such as amiodarone or statins could result in an increased risk of amphiphilic pulmonary toxicity.

Kroatisch

iako se pokazalo da nema rizika od fosfolipidoze u bolesnika kojima se daje temsirolimus, moguće je da kombinirana primjena temsirolimusa s drugim amfifiličnim sredstvima, kao što su amiodaron ili statini, dovede do povećanja rizika od amfifilične plućne toksičnosti.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis (vacuolation of lymphoid tissues) also occurred; although this was not related to clinical signs in dogs treated up to 6 months.

Kroatisch

fosfolipidoza (vakuolizacija limfoidnog tkiva) također se pojavila, iako to nije bilo povezano s kliničkim znacima kod pasa liječenih u trajanju do 6 mjeseci.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis (vacuolation of lymphoid tissue) also occurred; although this was not related to clinical signs in dogs treated up to 6 months.

Kroatisch

fosfolipidoza (vakuolizacija limfoidnog tkiva) također se pojavila; iako to nije bilo povezano s kliničkim znacima kod pasa liječenih u trajanju do 6 mjeseci.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

alveolar foamy macrophages (confirmed phospholipidosis) were seen in the lungs of rats, but not in monkeys, and the lymph nodes of rats and monkeys had macrophage aggregates.

Kroatisch

alveolarni pjenasti makrofagi (potvrđena fosfolipidoza) uočeni su u plućima štakora, ali ne u majmuna, a limfni čvorovi štakora i majmuna imali su nakupine makrofaga.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

other findings included an effect on the liver (elevation of liver transaminases) and retinal function, and potential for phospholipidosis in multiple organs without correlative toxicities.

Kroatisch

drugi nalazi uključuju učinke na jetru (povišene vrijednosti jetrenih transaminaza) i mrežnicu te moguću fosfolipidozu u više organa bez korelacijske toksičnosti.

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

Engels

phospholipidosis was seen mainly in the lungs in rodents (at exposures similar to humans) and monkeys (at exposures greater than 12 fold higher than human).

Kroatisch

fosfolipidi su uglavnom uočeni u plućima glodavaca (u izloženosti sličnoj onoj u ljudi) i u majmuna (u izloženostima većim od 12 puta od one u ljudi).

Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:

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