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med succesen hos gec i ryggen,har personalet fra apl international taget initiativet med andre udviklinger.
with the success of gec behind them personnel of alp international have gone on to initiate other developments.
efter markedsføring er et differentieringssyndrom, som retinoinsyresyndrom, også blevet rapporteret ved behandling af andre maligniteter end apl med trisenox.
in post marketing experience, a differentiation syndrome, like retinoic acid syndrome, has also been reported for the treatment of malignancies other than apl with trisenox.
leukocytose optrådte hos 50% af patienter med apl, vurderet ud fra en hæmatologisk bedømmelse frem for fra indberettede bivirkninger.
leukocytosis occurred in 50% of patients with apl, as determined by haematology assessments, rather than adverse event reports.
de fleste patienter vil ikke have behov for at afslutte trisenox-terapi under behandling af ra-apl syndromet.
the majority of patients do not require termination of trisenox therapy during treatment of the apl differentiation syndrome.
behandling af syndromet er ikke blevet nøje undersøgt, men højdosis steroider givet ved første mistanke om ra-apl syndromet synes at mindske tegn og symptomer.
the management of the syndrome has not been fully studied, but high-dose steroids have been used at the first suspicion of the apl differentiation syndrome and appear to mitigate signs and symptoms.
trisenox er blevet undersøgt hos 52 apl-patienter, som tidligere er blevet behandlet med anthracyclin og retinoid i to åbne, enkeltstrengede, ikke-komparative studier.
trisenox has been investigated in 52 apl patients, previously treated with an anthracycline and a retinoid regimen, in two open-label, single-arm, non-comparative studies.