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Francês

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Francês

composé suivant la revendication 1, qui est la 5-[[[3,5-bis(1,1-diméthyléthyl)-4-hydroxyphényl]amino]-[hexyl-(4-quinoléinylméthyl)amino]méthylène]-2,2-diméthyl-1,3-dioxanne-4,6-dione, ou un sel pharmaceutiquement acceptable de celle-ci.

Inglês

a compound of claim 1 which is 5-[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]amino][hexyl(4-quinolinylmethyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione, or a pharmaceutically acceptable salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 4
Qualidade:

Francês

procédé suivant la revendication 1, dans lequel le composé préparé est la 5-[[[3,5-bis(1,1-diméthyléthyl)-4-hydroxyphényl]amino][hexyl-(4-quinoléinylméthyl)amino]méthylène]-2,2-diméthyl-1,3-dioxanne-4,6-dione, ou un sel pharmaceutiquement acceptable de celle-ci.

Inglês

a process of claim 1 in which the compound prepared is 5-[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]amino][hexyl(4-quinolinylmethyl)amino]methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione, or a pharmaceutically acceptable salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 4
Qualidade:

Francês

composé selon la revendication 1, caractérisé en ce que le composé est choisi parmi: le n,n-diéthyl-4-((s)pipérazin-1-yl{3-[(1,3-thiazol-2-ylméthyl)amino]phényl}méthyl)benzamide; le n,n-diéthyl-4-((r)-pipérazin-1-yl{3-[(1,3-thiazol-2-ylméthyl)amino]phényl}méthyl)benzamide; le 4-[(s)-[3-(benzylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-((r)-pipérazin-1-yl{3-[(thién-2-ylméthyl)amino]phényl}méthyl)benzamide ; le n,n-diéthyl-4-((s)-pipérazin-1-yl{3-[(thién-2-ylméthyl)amino]phényl}méthyl)benzamide ; le n,n-diéthyl-4-[(s)-{3-[(2-furylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(r)-[3-(benzylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(r)-{3-[(2-furylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-((r)-pipérazin-1-yl{3-[(thién-3-ylméthyl)amino]phényl}méthyl)benzamide ; le n,n-diéthyl-4-((s)-pipérazin-1-yl{3-[(thién-3-ylméthyl)amino]phényl}méthyl)benzamide ; le n,n-diéthyl-4-[(r)-{3-[(3-furylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(r)-{3-[(2-phényléthyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[( r )-{3-[(cyclohexylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]- n,n -diéthylbenzamide ; le n,n-diéthyl-4-[(r)-pipérazin-1-yl(3-{[4-trifluorométhyl)benzyl]amino}phényl)méthyl]benzamide ; le 4-[(r)-{3-[(cyclopentylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-{3-[(cyclohexylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-{3-[(cyclohex-1-én-1-ylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(s)-{3-[méthyl(phényl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(s)-{3-[éthyl(phényl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(r)-{3-[méthyl(phényl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(r)-{3-[éthyl(phényl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(r)-{3-[(cyclohexylméthyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-[3-(cyclopentylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-[3-(cycloheptylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide; le 4-[(r)-[3-(cyclooctylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-[3-(cyclononylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-[3-(cyclohexylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(r)-{3-[(4-méthylphényl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(s)-{3-[(4-méthylphényl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(r)-{3-[(3-chlorophényl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-{3-[(3-chlorophényl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-{3-[(2-fluorophényl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-{3-[(2-fluorophényl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-[3-(benzoylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(r)-{3-[phénylacétyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(s)-[3-(benzoylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(s)-{3-[(phénylacétyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(r)-{3-[(2-méthyl-2-phénylpropanoyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le n,n-diéthyl-4-[(r)-(3-{[(3-fluorophényl)acétyl]amino}phényl)(pipérazin-1-yl)méthyl]benzamide; le 4-[(r)-{3-[(cyclohexylacétyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(r)-{3-[(3-phénylpropanoyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(r)-{3-[(cyclohexylcarbonyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(r)-{3-[(phénylsulfonyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(r)-{3-[(benzylsulfonyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(s)-{3-[(phénylsulfonyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[(r)-{3-[(anilinocarbonyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-{3-[(anilinocarbonothioyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n -diéthyl-4-[( s )-1-pipérazinyl[3-(propylamino)phényl]méthyl]benzamide; le 4-[( s )-[3-(dipropylamino)phényl]-1-pipérazinylméthyl]- n,n -diéthylbenzamide ; le n,n -diéthyl-4-[( r )-1-pipérazinyl [3-(propylamino)phényl]méthyl]benzamide ; le 4-[( r )-[3-(dipropylamino)phényl]-1-pipérazinylméthyl]- n,n -diéthylbenzamide ; le n,n -diéthyl-4-[( s )-1-pipérazinyl[3-[[[4-(3-pyridinyl)phényl]méthyl]amino]phényl]méthyl]benzamide ; le n,n -diéthyl-4-[( s )-[3-[[[4-(1 h -imidazol-1-yl)phényl]méthyl]amino]phényl]-1-pipérazinylméthyl]benzamide ; le n,n -diéthyl-4-[( s )-1-pipérazinyl{3-[(2-quinoléinylméthyl)amino]phényl}méthyl]benzamide ; le 4-[( r )-[3-[(2,2-diphényléthyl)amino]phényl]-1-pipérazinylméthyl]- n,n -diéthylbenzamide ; le 4-[( r )-[3-[[[4-(1,1-diméthyléthyl)phényl]méthyl]amino]phényl]-1-pipérazinylméthyl]- n,n -diéthylbenzamide; le n,n -diéthyl-4-[( r )-[3-[[(4-phénoxyphényl)méthyl]amino]phényl]-1-pipérazinylméthyl]benzamide ; le n,n -diéthyl-4-[( r )-[4-(2-propényl)-1-pipérazinyl][3-(propylamino)phényl]méthyl]benzamide ; le 4-{( r )-(3-aminophényl)[4-(2-méthoxyéthyl)pipérazin-1-yl]méthyl}-n,n-diéthylbenzamide ; le 4-{(r)-(3-aminophényl)[4-(3-méthoxypropyl)pipérazin-1-yl]méthyl}-n,n-diéthylbenzamide ; le n,n -diéthyl-4-[( r )-[4-(2-méthoxyéthyl)-1-pipérazinyl] [3-(propylamino)phényl]méthyl]benzamide ; le n,n -diéthyl-4-[(r)-[4-(3-méthoxypropyl)-1-pipérazinyl][3-(propylamino)phényl]méthyl]benzamide ; le 4-[( s )-[3-(cycloheptylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-[3-(cyclooctylamino)phényl](pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le n,n-diéthyl-4-[(s)-{3-[3-phénylpropanoyl)amino]phényl}(pipérazin-1-yl)méthyl]benzamide ; le 4-[( r )-(3-aminophényl)[4-(2-propényl)-1-pipérazinyl]méthyl]- n,n -diéthylbenzamide ; le 4-[( r )-(3-aminophényl)[4-(3-méthyl-2-butényl)-1-pipérazinyl]méthyl]- n,n -diéthylbenzamide ; le 4-[( r )-(3-aminophényl)[4-(cyclopropylméthyl)-1-pipérazinyl]méthyl]- n,n -diéthylbenzamide ; le n,n- diéthyl-4-[( r )-[4-(2-propényl)-1-pipérazinyl] [3-[(2-thiénylméthyl)amino]phényl]méthyl]benzamide ; le n,n -diéthyl-4-[( r )-[4-(3-méthyl-2-butényl)-1-pipérazinyl][3-[(2-thiénylméthyl)amino]phényl]méthyl]benzamide ; le 4-[( r )-[4-(cyclopropylméthyl)-1-pipérazinyl][3-[(2-thiénylméthyl)amino]phényl]méthyl]- n,n- diéthylbenzamide ; le 4-{( s )-[3-(cyclohexylamino)phényl][4-(cyclopropylméthyl)pipérazin-1-yl]méthyl}-n,n-diéthylbenzamide ; le 4-[(s)-[3-(cyclohexylamino)phényl](4-propylpipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-[3-(cyclohexylamino)phényl](4-éthylpipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-{(s)-(4-allylpipérazin-1-yl)[3-(cyclohexylamino)phényl]méthyl}-n,n-diéthylbenzamide ; le 4-[(s)-{3-[(cyclohexylcarbonyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-{3-[(cyclohexylacétyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(s)-{3-[cyclohexyl(méthyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; le 4-[(r)-{3-[cyclohexyl(méthyl)amino]phényl}(pipérazin-1-yl)méthyl]-n,n-diéthylbenzamide ; les énantiomères de ceux-ci ; et les sels pharmaceutiquement acceptables de ceux-ci.

Inglês

a compound according to claim 1, wherein the compound is selected from: n,n-diethyl-4-((s)piperazin-1-yl {3-[(1,3-thiazol-2-ylmethyl)amino]phenyl}methyl)benzamide; n,n-diethyl-4-((r)-piperazin-1-yl {3-[(1,3-thiazol-2-ylmethyl)amino]phenyl }methyl)benzamide; 4-[(s)-[3-(benzylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-((r)-piperazin-1-yl {3-[(thien-2-ylmethyl)amino]phenyl} methyl)benzamide; n,n-diethyl-4-((s)-piperazin-1-yl {3-[(thien-2-ylmethyl)amino]phenyl }methyl)benzamide; n,n-diethyl-4-[(s)-{3-[(2-furylmethyl)amino]phenyl }(piperazin-1-yl)methyl]benzamide; 4-[(r)-[3-(benzylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(r)-{3-[(2-furylmethyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; n,n-diethyl-4-((r)-piperazin-1-yl {3-[(thien-3-ylmethyl)amino]phenyl}methyl)benzamide; n,n-diethyl-4-((s)-piperazin-1-yl {3-[(thien-3-ylmethyl)amino]phenyl}methyl)benzamide; n,n-diethyl-4-[(r)-{3-[(3-furylmethyl)amino]phenyl} (piperazin-1-yl)methyl]benzamide; n,n-diethyl-4-[(r)-{ (3-[(2-phenylethyl)amino]phenyl} (piperazin-1-yl)methyl]benzamide; 4-(( r )-{3-[(cyclohexylmethyl)amino]phenyl} (piperazin-1-yl)methyl]- n , n- diethylbenzamide; n,n-diethyl-4-[(r)-piperazin-1-yl(3-{ [4-trifluoromethyl)benzyl]amino}phenyl)methyl]benzamide; 4-[(r)-{3-[(cyclopentylmethyl)animo]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-{ 3-[(cyclohexylmethyl)amino]phenyl }(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-{3-[(cyclohex-1-en-1-ylmethyl)ami no]phenyl (piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(s)-{ 3-[methyl(phenyl)amino]phenyl }(piperazin-1-yl)methyl]benzamide; n ,n-diethyl-4-[(s)- 3-[ethyl(phenyl)amino]phenyl }(piperazin-1-yl)methyl]benzamide; n,n-diethyl-4-[(r)-{ 3-[methyl(phenyl)amino]phenyl }(piperazin-1-yl)methyl]benzamide; n,n-diethyl-4-[(r)-{3-[ethyl(phenyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; 4-[(r)- {3-[(cyclohexylmethyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-[3-(cyclopentylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-[3-(cycloheptylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-[3-(cyclooctylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-[3-(cyclononylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-[3-(cyclohexylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(r)-{3-[(4-methylphenyl)amino]phenyl}(piperazin-1-yl) methyl]benzamide; n,n-diethyl-4-[(s)-{3-[(4-methylphenyl)amino]phenyl} (piperazin-1-yl)methyl]benzamide; 4-[(r)-{3-[(3-chlorophenyl)amino]phenyl }(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-{3-[(3-chlorophenyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-{3-[(2-fluorophenyl)amino]phenyl }(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-{3-[(2-fluorophenyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-[3-(benzoylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(r)-{3-[(phenylacetyl)amino]phenyl }(piperazin-1-yl)methyl]benzamide; 4-[(s)-[3-(benzoylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(s)- {3-[(phenylacetyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; n,n-diethyl-4-[(r)-{3-[(2-methyl-2-phenylpropanoyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; n,n-diethyl-4-[(r)-(3-{[(3-fluorophenyl)acetyl]amino}phenyl)(piperazin-1-yl)methyl]benzamide; 4-[(r)-{3-[(cyclohexylacetyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(r)-{3-[(3-phenylpropanoyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; 4-[(r)-{3-[(cyclohexylcarbonyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(r)-{3-[(phenylsulfonyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; 4-[(r)-{3-[(benzylsulfonyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(s)-{ 3-[(phenylsulfonyl)amino]phenyl}(piperazin-1-yl)methyl]benzamide; 4-[(r)-{3-[(anilinocarbonyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-{3-[(anilinocarbonothioyl)amino]phenyl} (piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n -diethyl-4-[( s )-1-piperazinyl[3-(propylamino)phenyl]methyl]benzamide; 4-[( s )-[3-(dipropylamino)phenyl]-1-piperazinylmethyl]- n,n -diethylbenzamide; n,n -diethyl-4-[( r )-1-piperazinyl[3-(propylamino)phenyl]methyl]benz-amide; 4-[( r )-[3-(dipropylamino)phenyl]-1-piperazinylmethyl]- n,n -diethylbenzamide; n,n -diethyl-4-[( s )-1-piperazinyl[3-[[[4-(3-pyridinyl)phenyl]methyl]-amino]phenyl]methyl]benzamide; n,n -diethyl-4-[(s)-[3-[[[4-(1 h -imidazol-1-yl)phenyl]methyl]amino]-phenyl]-1-piperazinylmethyl]benzamide; n,n- diethyl-4-[( s )-1-piperazinyl[3-[(2-quinolinylmethyl)amino]phenyl]-methyl]benzamide; 4-[( r )-[3-[(2,2-diphenylethyl)amino]phenyl]-1-piperazinylmethyl]- n , n- diethylbenzamide; 4-[( r )-[3-[[[4-(1,1-dimethylethyl)phenyl]methyl]amino]phenyl]-1-piperazinylmethyl]- n , n -diethylbenzamide; n , n -diethyl-4-[( r )-[3-[[(4-phenoxyphenyl)methyl]amino]phenyl]-1-piperazinylmethyl]benzamide; n,n -diethyl-4-[( r )-[4-(2-propenyl)-1-piperazinyl][3-(propylamino)-phenyl]methyl]benzamide; 4- {( r )-(3-aminophenyl)[4-(2-methoxyethyl)piperazin-1-yl]methyl} -n,n- diethylbenzamide; 4- {(r)-(3-aminophenyl)[4-(3-methoxypropyl)piperazin-1-yl]methyl}-n,n-diethylbenzamide; n , n -diethyl-4-[( r )-[4-(2-methoxyethyl)-1-piperazinyl] [3-(propylamino)-phenyl]methyl]benzamide; n,n- diethyl-4-[( r )-[4-(3-methoxypropyl)-1-piperazinyl][3-(propylamino)phenyl]methyl]benzamide; 4-[(s)-[3-(cycloheptylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-[3-(cyclooctylamino)phenyl](piperazin-1-yl)methyl]-n,n-diethylbenzamide; n,n-diethyl-4-[(s)-{3-[(3-phenylpropanoyl)amino]phenyl} (piperazin-1-yl)methyl]benzamide; 4-[( r )-(3-aminophenyl)[4-(2-propenyl)-1-piperazinyl]methyl]- n , n -diethylbenzamide; 4-[( r )-(3-aminophenyl)[4-(3-methyl-2-butenyl)-1-piperazinyl]methyl]- n,n -diethylbenzamide; 4-[( r )-(3-aminophenyl)[4-(cyclopropylmethyl)-1-piperazinyl]methyl]- n,n diethylbenzamide; n , n -diethyl-4-[( r )-[4-(2-propenyl)-1-piperazinyl][3-[(2-thienylmethyl)amino]phenyl]methyl]-benzamide; n,n diethyl-4-[( r )-[4-(3-methyl-2-butenyl)-1-piperazinyl][3-[(2-thienylmethyl)amino]phenyl]methyl]-benzamide; 4-[( r )-[4-(cyclopropylmethyl)-1-piperazinyl][3-[(2-thienylmethyl)amino]phenyl]methyl]- n,n- diethyl-benzamide; 4-{ (s)-[3-(cyclohexylamino)phenyl][4-(cyclopropylmethyl)piperazin-1-yl]methyl}-n,n-diethylbenzamide; 4-[(s)-[3-(cyclohexylamino)phenyl](4-propylpiperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-[3-(cyclohexylamino)phenyl](4-ethylpiperazin-1-yl)methyl]-n,n-diethylbenzamide; 4- (s)-(4-allylpiperazin-1-yl)[3-(cyclohexylamino)phenyl]methyl -n,n-diethylbenzamide; 4-[(s)- 3-[(cyclohexylcarbonyl)amino]phenyl (piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-{ 3-[(cyclohexylacetyl)amino]phenyl (piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(s)-{ 3-[cyclohexyl(methyl)amino]phenyl }(piperazin-1-yl)methyl]-n,n-diethylbenzamide; 4-[(r)-{3-[cyclohexyl(methyl)amino]phenyl}(piperazin-1-yl)methyl]-n,n-diethylbenzamide; enantiomers thereof; and pharmaceutically acceptable salts thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé suivant la revendication 5, ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel: r 22 et r 27 sont indépendamment choisis parmi: hydrogène, allyle, méthyle, éthyle, propyle, cyclopropylméthyle, n-butyle, ibutyle, ch 2 ch=c(ch 3 ) 2 , pyridinylméthyle, méthallyle, n-pentyle, i-pentyle, hexyle, benzyle, isoprényle, propargyle, picolinyle, méthoxyéthyle, cyclohexylméthyle, diméthylbutyle, éthoxyéthyle, méthyloxazolinylméthyle, naphtylméthyle, méthyloxazolinylméthyle, vinyloxyéthyle, pentafluorobenzyle, quinoléinylméthyle, carboxybenzyle, chlorothiényle, benzyloxybenzyle, phénylbenzyle, adamantyléthyle, cyclopropylméthoxybenzyle, méthoxybenzyle, méthylbenzyle, éthoxybenzyle, hydroxybenzyle, hydroxyméthylbenzyle, aminobenzyle, formylbenzyle, cyanobenzyle, cinnamyle, allyloxybenzyle, fluorobenzyle, difluorobenzyle, chlorobenzyle, chlorométhylbenzyle, fluorométhylbenzyle, iodobenzyle, bromobenzyle, cyclobutylméthyle, formaldoximebenzyle, cyclopentylméthyle, nitrobenzyle, (h 2 nc(=o))-benzyle, carbométhoxybenzyle, carboéthoxybenzyle, tétrazolylbenzyle et diméthylallyle, aminométhylbenzyle, (o-benzylformaldoxime)benzyle, (o-méthylformaldoxime)benzyle, (ch 3 o 2 co)-benzyle, (hoch 2 ch 2 n=ch)-benzyle, n-benzylaminocarbonylbenzyle, n-méthylaminobenzyle, n-éthylaminobenzyle, n-éthylaminométhylbenzyle, acétylbenzyle, acétoxybenzyle, n-hydroxylaminobenzyle, acide phénylméthylboronique, n-hydroxylaminométhylbenzyle, (hydroxyl)éthylbenzyle, (ch 3 c(=noh))-benzyle, (h 2 nnhc(=o))-benzyle, (h 2 nc(=o)nhn=ch)-benzyle, (ch 3 onhc(=o))-benzyle, (honhc(=o))-benzyle, (ch 3 nhc(=o)))-benzyle, n,n-diméthylaminocarbonylbenzyle, (hoch 2 ch(oh)ch 2 o)-benzyle, hydroxyéthoxybenzyl(oxazolidinyl)-benzyle, (hydroxyl)hexyle, hexényle, (hydroxy)octyle, (hydroxyl)pentyle, (carboxy)pentyle, (carbométhoxy)pentyle, (méthylthio)benzyle, (méthylsulfonyl)benzyle, n,n-diméthylaminométhylbenzyle, n-méthylaminométhylbenzyle, glycylaminobenzyle, n,n-diméthylglycylaminobenzyle, alanylaminobenzyle, (n-phénylméthoxycarbonyl)-alanylaminobenzyle, phénylalanylaminobenzyle, (n-phénylméthoxycarbonyl)phénylalanylaminobenzyle, (ch 3 ch 2 nhc(=o))-benzyle, n,n-diéthylaminocarbonylbenzyle, n-éthylaminocarbonylbenzyle, n-propylaminocarbonylbenzyle, n,n-diisopropylaminocarbonylbenzyle, n,n-di-n-propylaminocarbonylbenzyle, (hydroxypropynyl)benzyle, (imidazolyl-c(=o))-benzyle, trifluoroacétylbenzyle, (pyrazolyl)benzyle, (h 2 nso 2 )-benzyle, dihydroxyéthylbenzyle, (mehnc(=o)nh)-benzyle, (h 2 nc(=o)nh)-benzyle, (hc(=o)nh)-benzyle, méthanesulfonylpentyle, méthoxypentyle, n-formyl-n-méthylaminobenzyle, acétylaminobenzyle, propionylbenzyle, butyrylbenzyle, (ch 3 ch 2 c(=noh))-benzyle, (trifluorohydroxyéthyl)benzyle, (cf 3 c(=noh))-benzyle, (n-méthylglycyl)aminobenzyle, ((4-morpholino)éthyl)aminocarbonylbenzyle, (n,n-diméthylaminoéthyl)aminocarbonylbenzyle, (n,n-diéthylaminoéthyl)aminocarbonylbenzyle, (4-méthylpipérazin-1-yléthyl)aminocarbonylbenzyle, (benzyl-nhc(=o)o)benzyle, (ch 3 nhc(=o)o)benzyle, (nh 2 c(=o)ch 2 o)benzyle, (nh 2 c(=nh))benzyle, ((n-phénylméthoxycarbonyl)-glycylamino)benzyle, (imidazolylméthyl)benzyle, ((ch 3 ) 3 c-c(=o))benzyle, (n-méthyl-n-éthylaminoéthyl)aminocarbonylbenzyle, (pyrrolidinyléthyl)aminocarbonylbenzyle, (pipéridinyléthyl)aminocarbonylbenzyle.

Inglês

the compound of claim 5, or a pharmaceutically acceptable salt thereof, wherein: r 22 and r 27 are independently selected from: hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, ch 2 ch=c(ch 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyl-oxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl, vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl, benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (h 2 nc(=o))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and dimethylallyl, aminomethylbenzyl, (o-benzyl-formaldoxime)benzyl, (o-methyl-formaldoxime)benzyl, (ch 3 o 2 co)-benzyl, (hoch 2 ch 2 n=ch)-benzyl, n-benzylaminocarbonylbenzyl, n-methylaminobenzyl, n-ethylaminobenzyl, n-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, n-hydroxylaminobenzyl, phenylmethylboronic acid, n-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (ch 3 c(=noh))-benzyl, (h 2 nnhc(=o))-benzyl, (h 2 nc(=o)nhn=ch)-benzyl, (ch 3 onhc(=o))-benzyl, (honhc (=o)) -benzyl, (ch 3 nhc(=o))-benzyl, n,n-dimethylaminocarbonylbenzyl, (hoch 2 ch(oh)ch 2 o)-benzyl, hydroxyethoxybenzyl (oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, n,n-dimethylaminomethylbenzyl, n-methylaminomethylbenzyl, glycylaminobenzyl, n,n-dimethylglycylaminobenzyl, alanylaminobenzyl, (n-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (n-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (ch 3 ch 2 nhc(=o))-benzyl, n,n-diethylaminocarbonylbenzyl, n-ethylaminocarbonylbenzyl, n-propylaminocarbonylbenzyl, n,n-diisopropylaminocarbonylbenzyl, n, n-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-c(=o))-benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (h 2 nso 2 )-benzyl, dihydroxyethylbenzyl, (mehnc(=o)nh)-benzyl, (h 2 nc(=o)nh)-benzyl, (hc(=o)nh)-benzyl, methanesulfonylpentyl, methoxypentyl, n-formyl-n-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (ch 3 ch 2 c(=noh))-benzyl, (trifluorohydroxyethyl)benzyl, (cf 3 c(=noh))-benzyl, (n-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (n,n-dimethylaminoethyl)aminocarbonylbenzyl, (n,n-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-nhc(=o)o)benzyl, (ch 3 nhc(=o)o)benzyl, (nh 2 c(=o)ch 2 o)benzyl, (nh 2 c(=nh))benzyl, ((n-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((ch 3 ) 3 c-c(=o))benzyl, (n-methyl-n-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé suivant la revendication 6, ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel: r 4 et r 7 sont des groupes benzyles; r 22 et r 27 sont indépendamment choisis parmi: hydrogène, allyle, méthyle, éthyle, propyle, cyclopropylméthyle, n-butyle, ibutyle, ch 2 ch=c(ch 3 ) 2 , pyridinylméthyle, méthallyle, n-pentyle, i-pentyle, hexyle, benzyle, isoprényle, propargyle, picolinyle, méthoxyéthyle, cyclohexylméthyle, diméthylbutyle, éthoxyéthyle, méthyloxazolinylméthyle, naphtylméthyle, méthyloxazolinylméthyle, vinyloxyéthyle, pentafluorobenzyle, quinoléinylméthyle, carboxybenzyle, chlorothiényle, benzyloxybenzyle, phénylbenzyle, adamantyléthyle, cyclopropylméthoxybenzyle, méthoxybenzyle, méthylbenzyle, éthoxybenzyle, hydroxybenzyle, hydroxyméthylbenzyle, aminobenzyle, formylbenzyle, cyanobenzyle, cinnamyle, allyloxybenzyle, fluorobenzyle, difluorobenzyle, chlorobenzyle, chlorométhylbenzyle, fluorométhylbenzyle, iodobenzyle, bromobenzyle, cyclobutylméthyle, formaldoximebenzyle, cyclopentylméthyle, nitrobenzyle, (h 2 nc(=o))-benzyle, carbométhoxybenzyle, carboéthoxybenzyle, tétrazolylbenzyle et diméthylallyle, aminométhylbenzyle, (o-benzylformaldoxime)benzyle, (o-méthylformaldoxime)benzyle, (ch 3 o 2 co)-benzyle, (hoch 2 ch 2 n=ch)-benzyle, n-benzylaminocarbonylbenzyle, n-méthylaminobenzyle, n-éthylaminobenzyle, n-éthylaminométhylbenzyle, acétylbenzyle, acétoxybenzyle, n-hydroxylaminobenzyle, acide phénylméthylboronique, n-hydroxylaminométhylbenzyle, (hydroxyl)éthylbenzyle, (ch 3 c(=noh))-benzyle, (h 2 nnhc(=o))-benzyle, (h 2 nc(=o)nhn=ch)-benzyle, (ch 3 onhc(=o))-benzyle, (honhc(=o))benzyle, (ch 3 nhc(=o))benzyle, n,n-diméthylaminocarbonylbenzyle, (hoch 2 ch(oh)ch 2 o)benzyle, hydroxyéthoxybenzyl-(oxazolidinyl)benzyle, (hydroxyl)hexyle, hexényle, (hydroxy)octyle, (hydroxyl)pentyle, (carboxy)pentyle, (carbométhoxy)pentyle, (méthylthio)-benzyle, (méthylsulfonyl)benzyle, n,n-diméthylaminométhylbenzyle, n-méthylaminométhylbenzyle, glycylaminobenzyle, n,n-diméthylglycylaminobenzyle, alanylaminobenzyle, (n-phénylméthoxycarbonyl)alanylaminobenzyle, phénylalanylaminobenzyle, (n-phénylméthoxycarbonyl)phénylalanylaminobenzyle, (ch 3 ch 2 nhc(=o))-benzyle, n,n-diéthylaminocarbonylbenzyle, n-éthylaminocarbonylbenzyle, n-propylaminocarbonylbenzyle, n,n-diisopropylaminocarbonylbenzyle, n,n-di-n-propylaminocarbonylbenzyle, (hydroxypropynyl)benzyle, (imidazolyl-c(=o))-benzyle, trifluoroacétylbenzyle, (pyrazolyl)benzyle, (h 2 nso 2 )-benzyle, dihydroxyéthylbenzyle, (mehnc(=o)nh)-benzyle, (h 2 nc(=o)nh)-benzyle, (hc(=o)nh)-benzyle, méthanesulfonylpentyle, méthoxypentyle, n-formyl-n-méthylaminobenzyle, acétylaminobenzyle, propionylbenzyle, butyrylbenzyle, (ch 3 ch 2 c(=noh))-benzyle, (trifluorohydroxyéthyl)benzyle, (cf 3 c(=noh))-benzyle, (n-méthylglycyl)aminobenzyle, ((4-morpholino)éthyl)aminocarbonylbenzyle, (n,n-diméthylaminoéthyl)aminocarbonylbenzyle, (n,n-diéthylaminoéthyl)-aminocarbonylbenzyle, (4-méthylpipérazin-1-yléthyl)aminocarbonylbenzyle, (benzyl-nhc(=o)o)benzyle, (ch 3 nhc(=o)o)benzyle, (nh 2 c(=o)ch 2 o)-benzyle, (nh 2 c(=nh))benzyle, ((n-phénylméthoxycarbonyl)glycylamino)-benzyle, (imidazolylméthyl)benzyle, ((ch 3 ) 3 c-c(=o))benzyle, (n-méthyl-n-éthylaminoéthyl)aminocarbonylbenzyle, (pyrrolidinyléthyl)aminocarbonylbenzyle, (pipéridinyléthyl)aminocarbonylbenzyle.

Inglês

the compound of claim 6, or a pharmaceutically acceptable salt thereof, wherein: r 4 and r 7 are benzyl; r 22 and r 27 are independently selected from hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, ch 2 ch=c(ch 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyl-oxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl, vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl, benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (h 2 nc(=o))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and dimethylallyl, aminomethylbenzyl, (o-benzyl-formaldoxime)benzyl, (o-methyl-formaldoxime)benzyl, (ch 3 o 2 co)-benzyl, (hoch 2 ch 2 n=ch)-benzyl, n-benzylaminocarbonylbenzyl, n-methylaminobenzyl, n-ethylaminobenzyl, n-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, n-hydroxylaminobenzyl, phenylmethylboronic acid, n-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (ch 3 c(=noh))-benzyl, (h 2 nnhc(=o))-benzyl, (h 2 nc(=o)nhn=ch)-benzyl, (ch 3 onhc(=o))-benzyl, (honhc(=o))-benzyl, (ch 3 nhc(=o))-benzyl, n,n-dimethylaminocarbonylbenzyl, (hoch 2 ch(oh)ch 2 o)-benzyl, hydroxyethoxybenzyl (oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, n,n-dimethylaminomethylbenzyl, n-methylaminomethylbenzyl, glycylaminobenzyl, n,n-dimethylglycylaminobenzyl, alanylaminobenzyl, (n-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (n-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (ch 3 ch 2 nhc(=o))-benzyl, n,n-diethylaminocarbonylbenzyl, n-ethylaminocarbonylbenzyl, n-propylaminocarbonylbenzyl, n,n-diisopropylaminocarbonylbenzyl, n, n-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-c(=o))-benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (h 2 nso 2 )-benzyl, dihydroxyethylbenzyl, (mehnc(=o)nh)-benzyl, (h 2 nc(=o)nh)-benzyl, (hc(=o)nh)-benzyl, methanesulfonylpentyl, methoxypentyl, n-formyl-n-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (ch 3 ch 2 c(=noh))-benzyl, (trifluorohydroxyethyl)benzyl, (cf 3 c(=noh))-benzyl, (n-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (n,n-dimethylaminoethyl)aminocarbonylbenzyl, (n,n-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-nhc(=o)o)benzyl, (ch 3 nhc(=o)o)benzyl, (nh 2 c(=o)ch 2 o)benzyl, (nh 2 c(=nh))benzyl, ((n-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((ch 3 ) 3 c-c(=o))benzyl, (n-methyl-n-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé suivant la revendication 2, présentant la formule (le) ou (if): ou un sel pharmaceutiquement acceptable de celui-ci ou un dérivé d'acétate, de formiate ou de benzoate de groupes à fonction d'alcool et d'amine dans le composé des formules (le et if) ci-dessus dans lesquelles: r 5 est -or 20 ; r 20 est h ou n'importe quel groupe qui, lorsqu'il est administré à un sujet mammifère, se clive pour former un groupe hydroxyle libre; r 4 , r 7 , r 11 , r 12 , r 13 , r 14 , r 15 , m, r 22 , r 27 , r 32 , r 40 et r 41 sont comme il est défini dans la revendication 1; sous réserve que lorsque r 4 est un hydrogène, au moins deux des groupes suivants ne sont pas un hydrogène: r 7 , r 22 ou r 27 . composé suivant la revendication 9, ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel: r 4 et r 27 sont choisis parmi un groupe benzyle, fluorobenzyle, pyrrolylméthyle, méthoxybenzyle, isobutyle, nitrobenzyle ou aminobenzyle; r 22 et r 7 sont indépendamment choisis parmi: hydrogène, allyle, méthyle, éthyle, propyle, cyclopropylméthyle, n-butyle, ibutyle, ch 2 ch=c(ch 3 ) 2 , pyridinylméthyle, méthallyle, n-pentyle, i-pentyle, hexyle, benzyle, isoprényle, propargyle, picolinyle, méthoxyéthyle, cyclohexylméthyle, diméthylbutyle, éthoxyéthyle, méthyloxazolinylméthyle, naphtylméthyle, méthyloxazolinylméthyle, vinyloxyéthyle, pentafluorobenzyle, quinoléinylméthyle, carboxybenzyle, chlorothiényle, benzyloxybenzyle, phénylbenzyle, adamantyléthyle, cyclopropylméthoxybenzyle, méthoxybenzyle, méthylbenzyle, éthoxybenzyle, hydroxybenzyle, hydroxyméthylbenzyle, aminobenzyle, formylbenzyle, cyanobenzyle, cinnamyle, allyloxybenzyle, fluorobenzyle, difluorobenzyle, chlorobenzyle, chlorométhylbenzyle, fluorométhylbenzyle, iodobenzylc, bromobenzyle, cyclobutylméthyle, formaldoximebenzyle, cyclopentylméthyle, nitrobenzyle, (h 2 nc(=o))-benzyle, carbométhoxybenzyle, carboéthoxybenzyle, tétrazolylbenzyle et diméthylallyle, aminométhylbenzyle, (o-benzylformaldoxime)benzyle, (o-méthylformaldoxime)-benzyle, (ch 3 o 2 co)-benzyle, (hoch 2 ch 2 n=ch)-benzyle, n-benzylaminocarbonylbenzyle, n-méthylaminobenzyle, n-éthylaminobenzyle, n-éthylaminométhylbenzyle, acétylbenzyle, acétoxybenzyle, n-hydroxylaminobenzyle, acide phénylméthylboronique, n-hydroxylaminométhylbenzyle, (hydroxyl)éthylbenzyle, (ch 3 c(=noh))-benzyle, (h 2 nnhc(=o))-benzyle, (h 2 nc(=o)nhn=ch)-benzyle, (ch 3 onhc(=o))-benzyle, (honhc(=o))benzyle, (ch 3 nhc(=o))benzyle, n,n-diméthylaminocarbonylbenzyle, (hoch 2 ch(oh)ch 2 o)benzyle, hydroxyéthoxybenzyl-(oxazolidinyl)benzyle, (hydroxyl)hexyle, hexényle, (hydroxy)octyle, (hydroxyl)pentyle, (carboxy)pentyle, (carbométhoxy)pentyle, (méthylthio)-benzyle, (méthylsulfonyl)benzyle, n,n-diméthylaminométhylbenzyle, n-méthylaminométhylbenzyle, glycylaminobenzyle, n,n-diméthylglycylaminobenzyle, alanylaminobenzyle, (n-phénylméthoxycarbonyl)-alanylaminobenzyle, phénylalanylaminobenzyle, (n-phénylméthoxycarbonyl)-phénylalanylaminobenzyle, (ch 3 ch 2 nhc(=o))-benzyle, n,n-diéthylaminocarbonylbenzyle, n-éthylaminocarbonylbenzyle, n-propylaminocarbonylbenzyle, n,n-diisopropylaminocarbonylbenzyle, n,n-di-n-propylaminocarbonylbenzyle, (hydroxypropynyl)benzyle, (imidazolyl-c(=o))-benzyle, trifluoroacétylbenzyle, (pyrazolyl)benzyle, (h 2 nso 2 )-benzyle, dihydroxyéthylbenzyle, (mehnc(=o)nh)-benzyle, (h 2 nc(=o)nh)-benzyle, (hc(=o)nh)-benzyle, méthanesulfonylpentyle, méthoxypentyle, n-formyl-n-méthylaminobenzyle, acétylaminobenzyle, propionylbenzyle, butyrylbenzyle, (ch 3 ch 2 c(=noh))-benzyle, (trifluorohydroxyéthyl)benzyle, (cf 3 c(=noh))-benzyle, (n-méthylglycyl)aminobenzyle, ((4-morpholino)éthyl)aminocarbonylbenzyle, (n,n-diméthylaminoéthyl)aminocarbonylbenzyle, (n,n-diéthylaminoéthyl)aminocarbonylbenzyle, (4-méthylpipérazin-1-yléthyl)-aminocarbonylbenzyle, (benzyl-nhc(=o)o)benzyle, (ch 3 nhc(=o)o)benzyle, (nh 2 c(=o)ch 2 o)benzyle, (nh 2 c(=nh))benzyle, ((n-phénylméthoxycarbonyl)-glycylamino)benzyle, (imidazolylméthyl)benzyle, ((ch 3 ) 3 c-c(=o))benzyle, (n-méthyl-n-éthylaminoéthyl)aminocarbonylbenzyle, (pyrrolidinyléthyl)aminocarbonylbenzyle, (pipéridinyléthyl)aminocarbonylbenzyle.

Inglês

the compound of claim 2 having the formula (ie) or (if): or a pharmaceutically acceptable salt thereof or an acetate, formate or benzoate derivative of alcohol and amine functional groups in the compound of the above formulas (ie and if) wherein r 5 is -or 20 ; r 20 is h or any group that, when administered to a mammalian subject cleaves to form a free hydroxyl; r 4 , r 7 , r 11 , r 12 , r 13 , r 14 , r 15 , m, r 22 , r 27 , r 32 , r 40 and r 41 are as defined in claim 1; provided that when r 4 is hydrogen, at least two of the following are not hydrogen: r 7 , r 22 or r 27 ; a compound of claim 9, or a pharmaceutically acceptable salt thereof, wherein: r 4 and r 27 are selected from benyzl, fluorobenzyl, pyrrolylmethyl, methoxybenzyl, isobutyl, nitrobenzyl or aminobenzyl; r 22 and r 7 are independently selected from: hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, ch 2 ch=c(ch 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyl-oxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl, vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl, benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (h 2 nc(=o))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and dimethylallyl, aminomethylbenzyl, (o-benzyl-formaldoxime)benzyl, (o-methyl-formaldoxime)benzyl, (ch 3 o 2 co)-benzyl, (hoch 2 ch 2 n=ch)-benzyl, n-benzylaminocarbonylbenzyl, n-methylaminobenzyl, n-ethylaminobenzyl, n-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, n-hydroxylaminobenzyl, phenylmethylboronic acid, n-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (ch 3 c(=noh))-benzyl, (h 2 nnhc(=o))-benzyl, (h 2 nc(=o)nhn=ch)-benzyl, (ch 3 onhc(=o))-benzyl, (honhc(=o))-benzyl, (ch 3 nhc(=o))-benzyl, n,n-dimethylaminocarbonylbenzyl, (hoch 2 ch(oh)ch 2 o)-benzyl, hydroxyethoxybenzyl (oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, n,n-dimethylaminomethylbenzyl, n-methylaminomethylbenzyl, glycylaminobenzyl, n,n-dimethylglycylaminobenzyl, alanylaminobenzyl, (n-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (n-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (ch 3 ch 2 nhc(=o))-benzyl, n,n-diethylaminocarbonylbenzyl, n-ethylaminocarbonylbenzyl, n-propylaminocarbonylbenzyl, n,n-diisopropylaminocarbonylbenzyl, n, n-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-c(=o))-benzyl, trifluoroacetylbenzylt (pyrazolyl)benzyl, (h 2 nso 2 )-benzyl, dihydroxyethylbenzyl, (mehnc(=o)nh)-benzyl, (h 2 nc(=o)nh)-benzyl, (hc(=o)nh)-benzyl, methanesulfonylpentyl, methoxypentyl, n-formyl-n-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (ch 3 ch 2 c(=noh))-benzyl, (trifluorohydroxyethyl)benzyl, (cf 3 c(=noh))-benzyl, (n-methylglycyl)aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (n,n-dimethylaminoethyl)aminocarbonylbenzyl, (n,n-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-nhc(=o)o)benzyl, (ch 3 nhc(=o)o)benzyl, (nh 2 c(=o)ch 2 o)benzyl, (nh 2 c(=nh))benzyl, ((n-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((ch 3 ) 3 c-c(=o))benzyl, (n-methyl-n-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé suivant la revendication 13, ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel: r 4 et r 7 sont choisis parmi un groupe benzyle, fluorobenzyle, pyrrolylméthyle, méthoxybenzyle, isobutyle, nitrobenzyle ou aminobenzyle; r 5 est -oh; r 22 et r 23 sont indépendamment choisis parmi: hydrogène, allyle, méthyle, éthyle, propyle, cyclopropylméthyle, n-butyle, ibutyle, ch 2 ch=c(ch 3 ) 2 , pyridinylméthyle, méthallyle, n-pentyle, i-pentyle, hexyle, benzyle, isoprényle, propargyle, picolinyle, méthoxyéthyle, cyclohexylméthyle, diméthylbutyle, éthoxyéthyle, méthyloxazolinylméthyle, naphtylméthyle, méthyloxazolinylméthyle, vinyloxyéthyle, pentafluorobenzyle, quinoléinylméthyle, carboxybenzyle, chlorothiényle, benzyloxybenzyle, phénylbenzyle, adamantyléthyle, cyclopropylméthoxybenzyle, méthoxybenzyle, méthylbenzyle, éthoxybenzyle, hydroxybenzyle, hydroxyméthylbenzyle, aminobenzyle, formylbenzyle, cyanobenzyle, cinnamyle, allyloxybenzyle, fluorobenzyle, difluorobenzyle, chlorobenzyle, chlorométhylbenzyle, fluorométhylbenzyle, iodobenzyle, bromobenzyle, cyclobutylméthyle, formaldoximebenzyle, cyclopentylméthyle, nitrobenzyle, (h 2 nc(=o))-benzyle, carbométhoxybenzyle, carboéthoxybenzyle, tétrazolylbenzyle et diméthylallyle, aminométhylbenzyle, (o-benzylformaldoxime)benzyle, (o-méthylformaldoxime)-benzyle, (ch 3 o 2 co)-benzyle, (hoch 2 ch 2 n=ch)-benzyle, n-benzylaminocarbonylbenzyle, n-méthylaminobenzyle, n-éthylaminobenzyle, n-éthylaminométhylbenzyle, acétylbenzyle, acétoxybenzyle, n-hydroxylaminobenzyle, acide phénylméthylboronique, n-hydroxylaminométhylbenzyle, (hydroxyl)éthylbenzyle, (ch 3 c(=noh))-benzyle, (h 2 nnhc(=o))-benzyle, (h 2 nc(=o)nhn=ch)-benzyle, (ch 3 onhc(=o))-benzyle, (honhc(=o))-benzyle, (ch 3 nhc(=o))-benzyle, n,n-diméthylaminocarbonylbenzyle, (hoch 2 ch(oh)ch 2 o)-benzyle, hydroxyéthoxybenzyl(oxazolidinyl)-benzyle, (hydroxyl)hexyle, hexényle, (hydroxy)octyle, (hydroxyl)pentyle, (carboxy)pentyle, (carbométhoxy)pentyle, (méthylthio)benzyle, (méthylsulfonyl)-benzyle, n,n-diméthylaminométhylbenzyle, n-méthylaminométhylbenzyle, glycylaminobenzyle, n,n-diméthylglycylaminobenzyle, alanylaminobenzyle, (n-phénylméthoxycarbonyl)alanylaminobenzyle, phénylalanylaminobenzyle, (n-phénylméthoxycarbonyl)phénylalanylaminobenzyle, (ch 3 ch 2 nhc(=o))-benzyle, n,n-diéthylaminocarbonylbenzyle, n-éthylaminocarbonylbenzyle, n-propylaminocarbonylbenzyle, n,n-diisopropylaminocarbonylbenzyle, n,n-di-n-propylaminocarbonylbenzyle, (hydroxypropynyl)benzyle, (imidazolyl-c(=o))-benzyle, trifluoroacétylbenzyle, (pyrazolyl)benzyle, (h 2 nso 2 )-benzyle, dihydroxyéthylbenzyle, (mehnc(=o)nh)-benzyle, (h 2 nc(=o)nh)-benzyle, (hc(=o)nh)-benzyle, méthanesulfonylpentyle, méthoxypentyle, n-formyl-n-méthylaminobenzyle, acétylaminobenzyle, propionylbenzyle, butyrylbenzyle, (ch 3 ch 2 c(=noh))-benzyle, (trifluorohydroxyéthyl)benzyle, (cf 3 c(=noh))-benzyle, (n-méthylglycyl)aminobenzyle, ((4-morpholino)éthyl)aminocarbonylbenzyle, (n,n-diméthylaminoéthyl)aminocarbonylbenzyle, (n,n-diéthylaminoéthyl)aminocarbonylbenzyle, (4-méthylpipérazin-1-yléthyl)aminocarbonylbenzyle, (benzyl-nhc(=o)o)benzyle, (ch 3 nhc(=o)o)benzyle, (nh 2 c(=o)ch 2 o)benzyle, (nh 2 c(=nh))benzyle, ((n-phénylméthoxycarbonyl)glycylamino)benzyle, (imidazolylméthyl)benzyle, ((ch 3 ) 3 c-c(=o))benzyle, (n-méthyl-n-éthylaminoéthyl)aminocarbonylbenzyle, (pyrrolidinyléthyl)aminocarbonylbenzyle, (pipéridinyléthyl)aminocarbonylbenzyle.

Inglês

the compound of claim 13 or a pharmaceutically acceptable salt thereof, wherein: r 4 and r 7 are selected from benzyl, fluorobenzyl, pyrrolylmethyl, methoxybenzyl, isobutyl, nitrobenzyl or aminobenzyl; r 5 is -oh; r 22 and r 23 are independently selected from: hydrogen, allyl, methyl, ethyl, propyl, cyclopropylmethyl, n-butyl, i-butyl, ch 2 ch=c(ch 3 ) 2 , pyridinylmethyl, methallyl, n-pentyl, i-pentyl, hexyl, benzyl, isoprenyl, propargyl, picolinyl, methoxyethyl, cyclohexylmethyl, dimethyl-butyl, ethoxyethyl, methyl-oxazolinylmethyl, naphthylmethyl, methyloxazolinylmethyl, vinyloxyethyl, pentafluorobenzyl, quinolinylmethyl, carboxybenzyl, chloro-thienyl, benzyloxybenzyl, phenylbenzyl, adamantylethyl, cyclopropylmethoxybenzyl, methoxybenzyl, methylbenzyl, ethoxybenzyl, hydroxybenzyl, hydroxymethylbenzyl, aminobenzyl, formylbenzyl, cyanobenzyl, cinnamyl, allyloxybenzyl, fluorobenzyl, difluorobenzyl, chlorobenzyl, chloromethylbenzyl, fluoromethylbenzyl, iodobenzyl, bromobenzyl, cyclobutylmethyl, formaldoximebenzyl, cyclopentylmethyl, nitrobenzyl, (h 2 nc(=o))-benzyl, carbomethoxybenzyl, carboethoxybenzyl, tetrazolylbenzyl, and dimethylallyl, aminomethylbenzyl, (o-benzyl-formaldoxime)benzyl, (o-methyl-formaldoxime)benzyl, (ch 3 o 2 co)-benzyl, (hoch 2 ch 2 n=ch)-benzyl, n-benzylaminocarbonylbenzyl, n-methylaminobenzyl, n-ethylaminobenzyl, n-ethylaminomethylbenzyl, acetylbenzyl, acetoxybenzyl, n-hydroxylaminobenzyl, phenylmethylboronic acid, n-hydroxylaminomethylbenzyl, (hydroxyl)ethylbenzyl, (ch 3 c(=noh))-benzyl, (h 2 nnhc(=o))-benzyl, (h 2 nc(=o)nhn=ch)-benzyl, (ch 3 onhc(=o))-benzyl, (honhc(=o))-benzyl, (ch 3 nhc(=o))-benzyl, n,n-dimethylaminocarbonylbenzyl, (hoch 2 ch(oh)ch 2 o)-benzyl, hydroxyethoxybenzyl (oxazolidinyl)-benzyl, (hydroxyl)hexyl, hexenyl, (hydroxy)octyl, (hydroxyl)pentyl, (carboxy)pentyl, (carbomethoxy)pentyl, (methylthio)benzyl, (methylsulfonyl)benzyl, n,n-dimethylaminomethylbenzyl, n-methylaminomethylbenzyl, glycylaminobenzyl, n,n-dimethylglycylaminobenzyl, alanylaminobenzyl, (n-phenylmethoxycarbonyl)alanylaminobenzyl, phenylalanylaminobenzyl, (n-phenylmethoxycarbonyl) phenylalanylaminobenzyl, (ch 3 ch 2 nhc(=o))-benzyl, n,n-diethylaminocarbonylbenzyl, n-ethylaminocarbonylbenzyl, n-propylaminocarbonylbenzyl, n,n-diisopropylaminocarbonylbenzyl, n, n-di-n-propylaminocarbonylbenzyl, (hydroxypropynyl)benzyl, (imidazolyl-c(=o))-benzyl, trifluoroacetylbenzyl, (pyrazolyl)benzyl, (h 2 nso 2 )-benzyl, dihydroxyethylbenzyl, (mehnc(=o)nh)-benzyl, (h 2 nc(=o)nh)-benzyl, (hc(=o)nh)-benzyl, methanesulfonylpentyl, methoxypentyl, n-formyl-n-methylaminobenzyl, acetylaminobenzyl, propionylbenzyl, butyrylbenzyl, (ch 3 ch 2 c(=noh))-benzyl, (trifluorohydroxyethyl)benzyl, (cf 3 c(=noh))-benzyl, (n-methylglycyl) aminobenzyl, ((4-morpholino)ethyl)aminocarbonylbenzyl, (n,n-dimethylaminoethyl)aminocarbonylbenzyl, (n,n-diethylaminoethyl)aminocarbonylbenzyl, (4-methylpiperazin-1-ylethyl)aminocarbonylbenzyl, (benzyl-nhc(=o)o)benzyl, (ch 3 nhc(=o)o)benzyl, (nh 2 c(=o)ch 2 o)benzyl, (nh 2 c(=nh))benzyl, ((n-phenylmethoxycarbonyl)glycylamino)benzyl, (imidazolylmethyl)benzyl, ((ch 3 ) 3 c-c(=o))benzyl, (n-methyl-n-ethylaminoethyl)aminocarbonylbenzyl, (pyrrolidinylethyl)aminocarbonylbenzyl, (piperidinylethyl)aminocarbonylbenzyl.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composés de formule générale dans laquelle r 1 et r 2 ont la signification suivante : r 1 r 2 3,5-di-(trifluorométhyl)-phényle méthyle 2-fluoro-5-méthylphényle méthyle 2-benzofurannyle méthyle 2-quinoléinyle hydrogène 4-fluorophényle méthyle 4-nitrophényle méthyle 4-chlorophényle méthyle 4-chlorophényle ethyle β-phényléthényle méthyle o-tolyle méthyle p-anisyle méthyle 4-biphénylyle méthyle cyclopropyle cyclopropyle β-(2-furyl)-éthényle méthyle β-(3,4,5-triméthoxyphényl)-éthényle méthyle α, α, α-trifluoro-m-tolyle méthyle 3-bromophényle méthyle 2-chlorophényle méthyle 3-nitrophényle méthyle 5-chloro-3-méthyl-2-benzothiényle méthyle 3-chlorophényle méthyle 3,4-dichlorophényle méthyle 2,4-dichlorophényle méthyle 2,4-dichlorophényle 3-pyridylméthyle 3-méthyl-2-benzothiényle méthyle 2,5-dichlorophényle méthyle 4-éthylphényle méthyle 3-éthylphényle méthyle 3,4-diméthylphényle méthyle 6-méthyl-2-naphtyle méthyle 4-difluorométhoxyphényle méthyle 4-chlorophényle néopentyle 3,5-di-(trifluorométhyl)-phényle ethyle 3-phénantryle méthyle 2-fluorényle méthyle isopropyle méthyle 4-chlorophényle n-propyle 4-chlorophényle cyclopropyle 3-chlorophényle ethyle 4-fluorophényle ethyle 4-bromophényle ethyle 4-tert-butylphényle méthyle cyclopropyle méthyle 2-quinoléinylméthyle méthyle 3-fluoro-5-trifluorométhylphényle méthyle 3,5-difluorophényle méthyle 3,5-difluorophényle ethyle 2-fluoroohényle ethyle 3,4-diméthoxyphényle méthyle p-tolyle ethyle 3-trifluorométhoxyphényle méthyle 3-fluoro-5-trifluorométhylphényle ethyle cyclohexyle méthyle 4-chlorophényle trifluorométhyle 3,4-diméthoxybenzyle méthyle α, α, α-trifluoro-m-tolyle trifluorométhyle α, α, α-trifluoro-m-tolyle ethyle 3,5-dichlorophényle méthyle β-(2-naphtyl)éthényle trifluorométhyle méthyle méthyle α, α, α-trifluoro-m-tolyle n-propyle α, α, α-trifluoro-m-tolyle cyclopropyle 2-chloro-5-trifluorométhylphényle méthyle 2-méthylthio-5-trifluorométhylphényle méthyle 4-chloro-3-trifluorométhylbenzyle méthyle 4-méthoxybenzyle méthyle α, α, α-trifluoro-m-tolyle isopropyle α, α, α-trifluoro-m-tolyle α, α, α-trifluoro-m-tolyle 4-éthoxyphényle méthyle 3-chloro-4-fluorophényle méthyle 2,3-dichlorophényle méthyle p-tolyle trifluorométhyle 4-(2,4-dichlorophénoxy)-phényle méthyle 4-(4-nitrophénoxy)-phényle méthyle 4-(4-méthoxyphénoxy)-phényle méthyle 3,4-méthylènedioxyphényle méthyle 7-benzodioxannyle méthyle 3-bromophényle ethyle 3-fluoro-5-trifluorométhylphényle cyclopropyle 2,3,4-trichlorophényle méthyle 4-chloro-3-méthylphényle méthyle p-tolyle n-propyle 4-phénoxyphényle cyclopropyle 3-bromophényle cyclopropyle 3-chlorophényle cyclopropyle 3-fluorophényle cyclopropyle 3-bromophényle n-propyle 3-chlorophényle n-propyle 4-fluoro-3-trifluorométhylphényle n-propyle 3-fluorophényle n-propyle 4-phénoxyphényle n-propyle 3-fluoro-5-trifluorométhylphényle n-propyle 3-bromophényle trifluorométhyle 3-chlorophényle trifluorométhyle 4-phénoxyphényle trifluorométhyle 3-bromophényle isopropyle 3-chlorophényle isopropyle 4-phénoxyphényle isopropyle 4-fluoro-3-trifluorométhylphényle cyclopropyle 4-fluorophényle cyclopropyle 4-(n-propyl)-phényle méthyle 4-méthoxy-3-nitrophényle méthyle 2,4-diméthoxyphényle méthyle 4-fluoro-3-trifluorométhylphényle isopropyle 3-iodophényle méthyle 4-iodophényle méthyle 2-(4-méthoxyphényl)-éthyle méthyle 1,4,8-triméthyl-nona-1,3,7-triényle méthyle 1-méthyl-2-(3,4-méthylènedioxyphényl)-éthyle méthyle produit fongicide, caractérisé en ce qu' il contient une quantité efficace d'au moins un composé selon la revendication 1 ainsi que des produits auxiliaires de formulation.

Inglês

a compound of the general formula in which r 1 and r 2 have the following meanings: r 1 r 2 3,5-di(trifluoromethyl)phenyl methyl 2-fluoro-5-methylphenyl methyl 2-benzofuranyl methyl 2-quinolinyl hydrogen 4-fluorophenyl methyl 4-nitrophenyl methyl 4-chlorophenyl methyl 4-chlorophenyl ethyl β-phenylethenyl methyl o-tolyl methyl p-anisyl methyl 4-biphenylyl methyl cyclopropyl cyclopropyl β-(2-furyl)ethenyl methyl β-(3,4,5-trimethoxyphenyl)ethenyl methyl α,α,α-trifluoro-m-tolyl methyl 3-bromophenyl methyl 2-chlorophenyl methyl 3-nitrophenyl methyl 5-chloro-3-methyl-2-benzothienyl methyl 3-chlorophenyl methyl 3-4-dichlorophenyl methyl 2,4-dichlorophenyl methyl 2,4-dichlorophenyl 3-pyridylmethyl 3-methyl-2-benzothienyl methyl 2,5-dichlorophenyl methyl 4-ethylphenyl methyl 3-ethylphenyl methyl 3,4-dimethylphenyl methyl 6-methyl-2-naphthyl methyl 4-difluoromethoxyphenyl methyl 4-chlorophenyl neopentyl 3,5-di(trifluoromethyl)phenyl ethyl 3-phenanthryl methyl 2-fluorenyl methyl isopropyl methyl 4-chlorophenyl n-propyl 4-chlorophenyl cyclopropyl 3-chlorophenyl ethyl 4-fluorophenyl ethyl 4-bromophenyl ethyl 4-tert-butylphenyl methyl cyclopropyl methyl 2-quinolinylmethyl methyl 3-fluoro-5-trifluoromethylphenyl methyl 3,5-difluorophenyl methyl 3,5-difluorophenyl ethyl 2-fluorophenyl ethyl 3,4-dimethoxyphenyl methyl p-tolyl ethyl 3-trifluoromethoxyphenyl methyl 3-fluoro-5-trifluoromethylphenyl ethyl cyclohexyl methyl 4-chlorophenyl trifluoromethyl 3,4-dimethoxybenzyl methyl α,α,α-trifluoro-m-tolyl trifluoromethyl α,α,α-trifluoro-m-tolyl ethyl 3,5-dichlorophenyl methyl β-(2-naphthyl)ethenyl trifluoromethyl methyl methyl α,α,α-trifluoro-m-tolyl n-propyl α,α,α-trifluoro-m-tolyl cyclopropyl 2-chloro-5-trifluoromethylphenyl methyl 2-methylthio-5-trifluoromethylphenyl methyl 4-chloro-3-trifluoromethylbenzyl methyl 4-methoxybenzyl methyl α,α,α-trifluoro-m-tolyl isopropyl a,a,a-trifluoro-m-tolyl α,α,α,trifluoro-m-tolyl 4-ethoxyphenyl methyl 3-chloro-4-fluorophenyl methyl 2,3-dichlorophenyl methyl p-tolyl trifluoromethyl 4-(2,4-dichlorophenoxy)phenyl methyl 4-(4-nitrophenoxy)phenyl methyl 4-(4-methoxyphenoxy)phenyl methyl 3,4-methylenedioxyphenyl methyl 7-benzodioxanyl methyl 3-bromophenyl ethyl 3-fluoro-5-trifluoromethylphenyl cyclopropyl 2,3,4-trichlorophenyl methyl 4-chloro-3-methylphenyl methyl p-tolyl n-propyl 4-phenoxyphenyl cyclopropyl 3-bromophenyl cyclopropyl 3-chlorophenyl cyclopropyl 3-fluorophenyl cyclopropyl 3-bromophenyl n-propyl 3-chlorophenyl n-propyl 4-fluoro-3-trifluoromethylphenyl n-propyl 3-fluorophenyl n-propyl 4-phenoxyphenyl n-propyl 3-fluoro-5-trifluoromethylphenyl n-propyl 3-bromophenyl trifluoromethyl 3-chlorophenyl trifluoromethyl 4-phenoxyphenyl trifluoromethyl 3-bromophenyl isopropyl 3-chlorophenyl isopropyl 4-phenoxyphenyl isopropyl 4-fluoro-3-trifluoromethylphenyl cyclopropyl 4-fluorophenyl cyclopropyl 4-(n-propyl)phenyl methyl 4-methoxy-3-nitrophenyl methyl 2,4-dimethoxyphenyl methyl 4-fluoro-3-trifluoromethylphenyl isopropyl 3-iodophenyl methyl 4-iodophenyl methyl 2-(4-methoxyphenyl)ethyl methyl 1,4,8-trimethyl-nona-1,3,7-trienyl methyl 1-methyl-2-(3,4-methylenedioxyphenyl)ethyl methyl a fungicidal composition, characterized in that it contains an effective amount of at least one compound according to claim 1 as well as formulation adjuvants.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé, qui est: le n-[2-(2-hydroxyéthoxy)éthyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-benzyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(2-fluorobenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(3-fluorobenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(4-fluorobenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-furanyl)méthyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(4-méthoxybenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-pipéronyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(3,4-diméthoxybenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-thiényl)méthyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[6-(2,3-dihydro-1,4-benzodioxinyl)méthyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(2-fluoro-4-éthoxybenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(4-éthoxybenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(3-éthoxypropyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(2-fluoro-4-isopropoxybenzyl)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(méthylaminométhyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[3-(1-imidazolyl)propyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(1-méthylaminoéthyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(éthylaminométhyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(1-imidazolylméthyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(méthylaminométhyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoléine-3-carboxamide; le n-[4-(éthylaminométhyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(diméthylaminométhyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinotéine-3-carboxamide; le chlorhydrate de n-[3-(diméthylaminométhyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoléine-3-carboxamide; le n-[3-(éthylaminométhyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(1-imidazolylméthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(1-imidazolylméthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-benzyl-6-méthoxyméthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-thiényl)méthyl]-6-méthoxyméthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(3-éthoxy)propyl]-6-méthoxyméthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(méthylaminométhyl)benzyl]-6-méthoxyméthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(méthylaminométhyl)benzyl]-6-méthoxyméthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-thiényl)méthyl]-6-(1-morpholino)-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-benzyl-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(4-éthoxybenzyl)-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-thiényl)méthyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(3-éthoxypropyl)-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(isopropoxy)propyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-tétrahydrofuranyl)méthyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-pipéronyl-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(méthoxy)propyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(2-fluorobenzyl)-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(3-fluorobenzyl)-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(2-pyridyl)méthyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(3-pyridyl)méthyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[(3-thiényl)méthyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(méthylaminométhyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(éthylaminométhyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(1-méthylaminoéthyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[3-(méthylaminométhyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-{3-[(1-méthyl)aminoéthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[(1-imidazolyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(1-imidazolyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-benzyl-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(méthylaminométhyl)benzyl]-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(diméthylaminométhyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-[4-(méthylaminométhyl)benzyl]-7-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le chlorhydrate de n-benzyl-8-fluoro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-4-fluorobenzyl-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{[4-[2-(1-cyclohexyl)éthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(2-pyridyl)méthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-[4-(2-quinoléinylméthyl)pipérazinyl]méthyl]}benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-[4-(4-chlorobenzhydryl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-[4-(4-acétylphényl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{[4-[1-(4-pyridyl)méthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n- {4-[1-[4-(4-biphénylméthyl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(4-oxopipéridinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(dibenzylaminométhyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n- {4-[[2-(4-morpholinyl)éthyl]aminométhyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[3-(4-morpholinyl)propyl]aminométhyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[2-(diisopropylamino)éthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[2-(4-morpholinyl)éthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[(2-(1-pipéridinyl)éthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[2-(1-pyrrolidinyl)éthoxy]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(4-morpholinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[1-[4-(2-méthoxyphényl)pipérazinyl]méthyl]benzyl]}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[1-[4-(2-pyridinyl)pipérazinyl]méthyl]benzyl]}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-[4-(2-pyrimidinyl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide le n-{4-[1-[4-(4-chlorophényl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-[4-(4-fluorophényl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(4-acétylpipérazinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n- {4-[1-(4-benzylpipérazinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(n-benzyl-n-éthylamino)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(n-benzyl-n-méthylamino)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(n-méthyl-n-phénéthylamino)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[1-(4-méthyl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[[1-(4-pipéronyl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(1-pipéridinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(1-pyrrolidinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(1,2,3,4-tétrahydroisoquinolinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[(4-morpholinyl)méthyl]benzyl}-6-méthoxyméthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[1-[4-(3-trifluorométhylphényl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[[1-(4-benzyl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[n-benzyl-n-méthylamino)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[[1-(4-méthyl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[[1-(4-phényl)pipérazinyl]méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; et le n{[3-[1-(pyrrolidinyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[4-(1,2,3,4-4h-pyrazino[1,2-a]benzimidazolyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[4-(1,2,3,4,5,6-6h-1,4-diazépino[1,2-a]benzimidazolyl)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(1-méthylaminoéthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(4-morpholinylméthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(4-méthylpipérazinyl)méthyl]benzyl}-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(4-morpholinylméthyl)benzyl]-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(4-morpholinylméthyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(4-morpholinylméthyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(4-méthylpipérazinyl)méthyl]benzyl}-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(4-morpholinylméthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(1-pyrrolidinylméthyl)benzyl]-4-oxo-6-chloro-1,4-dihydroquinoléine-3-carboxamide; le [4-(2,2,2-trifluoroéthylaminométhyl)benzyl]-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(1-pipéridinylméthyl)benzyl]-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(1-pipéridinylméthyl)benzyl]-6-fluoro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[1-(2-méthylimidazolyl)méthyl]benzyl}-6-fluoro-4-oxo-1,4-dihydroquino-léine-3-carboxamide; le n-[3-(4-morpholinylméthyl)benzyl]-6-méthyl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[4-(1-pyrrolidinylméthyl)benzyl]-6-fluoro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; et le n-[4-(4-morpholinylméthyl)benzyl]-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(n-benzyl-n-méthylaminométhyl)benzyl]-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[1-(4-méthylpipérazinyl)méthyl]benzyl}-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le [4-(2,2,2-trifluoroéthylaminométhyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[4-(2-pyrimidinyl)pipérazinylméthyl]benzyl}-6-méthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{3-[1-(1,2,3,4-tétrahydroisoquinoléine)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-[3-(4-morpholinylméthyl)benzyl]-6-fluoro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[2-(éthoxyéthoxy)méthyl]benzyl}-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n- {4-[2-(cyclohexyloxyéthoxy)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[2-(phénoxyéthoxy)méthyl]benzyl}-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(r)-[3-(1-méthylaminoéthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-(s)-[3-(1-méthylaminoéthyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-tétrahydrofurfuryl-4-oxo-1,4-dihydroquinoléine-3-carboxamide; le n-{4-[(n-méthyl-2-phénéthylamino)méthyl]benzyl}-6-éthoxy-4-oxo-1,4-dihydroquinoléine-3-carboxamide; ou un de ses sels pharmaceutiquement acceptables.

Inglês

a compound which is: n-[2-(2-hydroxyethoxy)ethyl] 4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-benzyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(2-fluorobenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(3-fluorobenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(4-fluorobenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-furanyl)methyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(4-methoxybenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-piperonyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(3,4-dimethoxybenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-thienyl)methyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n- [6- (2,3-dihydro-1,4-benzodioxinyl)methyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(2-fluoro-4-ethoxybenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(4-ethoxybenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(3-ethoxypropyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(2-fluoro-4-isopropoxybenzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n- [4-(methylaminomethyl)benzyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[3-(1-imidazolyl)propyl]-4-oxo-1,4-dihydro-quinoline-3 -carboxamidehydrochloride n-[4-(1-methylaminoethyl)benzyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[4-(ethylaminomethyl)benzyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[4-(1-imidazolylmethyl)benzyl]-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[4-(methylaminomethyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[4-(ethylaminomethyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n- [4-(dimethylaminomethyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[3-(dimethylaminomethyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[3-(ethylaminomethyl)benzyl)-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[4-(1-imidazolylmethyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[3-(1-imidazolylmethyl)benzyl]-6-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-benzyl-6-methoxymethyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-thienyl)methyl]-6-methoxymethyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(3-ethoxy)propyl]-6-methoxymethyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[4-(methylaminomethyl)benzyl]-6-methoxymethyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[3-(methylaminomethyl)benzyl]-6-methoxymethyl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-thienyl)methyl]-6-(1-morpholino)-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-benzyl-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(4-ethoxybenzyl)-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-thienyl)methyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide n-(3-ethoxypropyl)-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[3-(isopropoxy)propyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-tetrahydrofuranyl)methyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-piperonyl-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[3-(methoxy)propyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(2-fluorobenzyl)-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-(3-fluorobenzyl)-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(2-pyridyl)methyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(3-pyridyl)methyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[(3-thienyl)methyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[4-(methylaminomethyl)benzyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n- [4-(ethylaminomethyl)benzyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[4-(1-methylaminoethyl)benzyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[3-(methylaminomethyl)benzyl]-6-ethoxy-4-oxo-1,4-, dihydro-quinoline-3-carboxamide hydrochloride; n-{3-[(1-methyl)aminoethyl]benzyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[3-[(1-imidazolyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[(1-imidazolyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-benzyl-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-[4-(methylaminomethyl)benzyl]-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[4-(dimethylaminomethyl)benzyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-[4-(methylaminomethyl)benzyl]-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-benzyl-8-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxamide hydrochloride; n-4-fluorobenzyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{[4-[2-(1-cyclohexyl)ethoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(2-pyridyl)methoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-[4-(2-quinolinylmethyl)piperazinyl]methyl]}benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-[4-(4-chlorobenzhydryl)piperazinyl]methyl]benzyl)-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-[4-(4-acetylphenyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{[4-[1-(4-pyridyl)methoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n{4-[1-[4-(4-biphenylmethyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(4-oxopiperidinyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[4-(dibenzylaminomethyl)benzyl]-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[[2-(4-morpholinyl)ethyl]aminomethyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[[3-(4-morpholinyl)propyl]aminomethyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[[2-(diisopropylamino)ethoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[[2-(4-morpholinyl)ethoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[[(2-(1-piperidinyl)ethoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[[2-(1-pyrrolidinyl)ethoxy]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[(4-morpholiny)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{(4-[[1-[4-(2-methoxyphenyl)piperazinyl]methyl] benzyl]}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[[1-[4-(2-pyridinyl)piperazinyl]methyl]benzyl)}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-[4-(2-pyrimidinyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-[4-(4-chlorophenyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-[4-(4-fluorophenyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(4-acetylpiperazinyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(4-benzylpiperazinyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[(n-benzyl-n-ethylamino)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[(n-benzyl-n-methylamino)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[(n-methyl-n-phenethylamino)methyl]benzyl}-6-ethoxy-4-oxo-1, 4-dihydroquinoline-3-carboxamide; n-{4-[[1-(4-methyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[[1-(4-piperonyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[(1-piperidinyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[(1-pyrrolidinyl)methyl]benzyl}-6-ethoxy-4-oxo-1, 4-dihydroquinoline-3-carboxamide; n-{4-[1-(1,2,3,4-tetrahydroisoquinolinyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[ (4-morpholinyl)methyl]benzyl}-6-methoxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[1-[4- (3-trifluoromethylphenyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[[1-(4-benzyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[(n-benzyl-n-methylamino)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[[1-(4-methyl) piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[[1-(4-phenyl)piperazinyl]methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; and n{[3-[1-(pyrrolidinyl)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[4-(1,2,3,4-4h-pyrazino[1,2-a]benzimadazolyl)methyl] benzyl} 6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[4-(1,2,3,4,5,6-6h-1,4-diazepino[1,2-a]benzimidazolyl) methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(1-methylaminoethyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[4-(4-morpholinylmethyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(4-methylpiperazinyl)methyl]benzyl}-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(4-morpholinylmethyl)benzyl]-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(4-morpholinylmethyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[4-(4-morpholinylmethyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(4-methylpiperazinyl)methyl]benzyl}-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(4-morpholinylmethyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(1-pyrrolidinylmethyl)benzyl]-4-oxo-6-chloro-1,4-dihydroquinoline-3-carboxamide; [4-(2,2,2-trifluoroethylaminomethyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[4-(1-piperidinylmethyl)benzyl]-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[4-(1-piperidinylmethyl)benzyl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[1-(2-methylimidazolyl)methyl]benzyl}-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(4-morpholinylmethyl)benzyl]-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[4-(1-pyrrolidinylmethyl)benzyl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide; and n-[4-(4-morpholinylmethyl)benzyl]-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-[3-(n-benzyl-n-methylaminomethyl)benzyl]-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[1-(4-methylpiperazinyl)methyl]benzyl}-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; [4-(2,2,2-trifluoroethylaminomethyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[4-(2-pyrimidinyl)piperazinylmethyl]benzyl}-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{3-[1-(1,2,3,4-tetrahydroisoquinoline)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n- [3- (4-morpholinylmethyl)benzyl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[2-(ethoxyethoxy)methyl]benzyl}-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[2-(cyclohexoxyethoxy)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-{4-[2-(phenoxyethoxy)methyl]benzyl}-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-(r)-[3-(1-methylaminoethyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-(s)-[3-(1-methylaminoethyl)benzyl]-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide; n-tetrahydrofurfuryl-4-oxo-1,4-dihydro-quinoline-3-carboxamide; n-{4-[(n-methyl-2-phenethylamino)methyl]benzyl}-6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide; or a pharmaceutically acceptable salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé selon la revendication 1, dans lequel le composé est : amd7490, la n-(2-pyridinyméthyl)-n'-(6,7,8,9-tétrahydro-5 h -cyclo-hepta[ b ]pyridin-9-yl)-1,4-benzénediméthanamine ; amd7491, la n-(2-pyridinylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7492, la n-(2-pyridinylméthyl)-n'-(6,7-dihydro-5 h -cyclopenta[b]pyridin-7-yl)-1,4-benzènediméthanamine ; amd8766, la n-(2-pyridinylméthyl)-n'-(1,2,3,4-tétrahydro-1 -naphtalényl)-1,4-benzènediméthanamine ; amd8789, la n-(2-pyridinylméthyl)-n'-(1-naphtalényl)- 1 ,4-benzènediméthanamine ; amd8776, la n-(2-pyridinylméthyl)-n'-(8-quinoléinyl)-1,4-benzènediméthanamine ; amd8859, la n-(2-pyridinylméthyl)-n'-[2-[(2-pyridinylméthyl)amino]éthyl]-n'-(1-méthyl-1,2,3,4-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8867, la n-(2-pyridinylméthyl)-n'-[2-[(1 h imidazol-2-ylméthyl)-amino]éthyl]-n'-(1-méthyl-1,2,3,4-tétrahydro-8-quinoléinyl)-1,4-benzène-diméthanamine ; amd8746, la n-(2-pyridinylméthyl)-n'-(1,2,3,4-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8835, la n-(2-pyridinylméthyl)-n'-[2-[(1 h -imidazol-2-ylméthyl)-amino]éthyl]-n'-(1,2,3,4-tétrahydro-1-naphtalényl)-1,4-benzènediméthanamine ; amd8833, la n-(2-pyridinylmëthyl)-n'-(2-phënyl-5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8825, la n,n'-bis(2-pyridinylméthyl)-n'-(2-phényl-5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8869, la n-(2-pyridinylméthyl)-n'-(5,6,7,8-tétrahydro-5-quinoléinyl)-1,4-benzènediméthanamine ; amd8876, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-5-quinoléinyl)-1,4-benzènediméthanamine ; amd8751, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8777, la n-(2-pyridinylméthyl)-n'-[(2-amino-3-phényl)propyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8763, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-4-ylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8771, la n-(2-pyridinylméthyl)-n'-(2-quinoléinylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8778, la n-(2-pyridinylméthyl)-n'-(2-(2-naphtoyl)aminoéthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8781, la n-(2-pyridinylméthyl)-n'-[( s )-(2-acétylamino-3-phényl)propyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8782, la n-(2-pyridinylméthyl)-n' -[( s )-(2-acétylamino-3-phényl)propyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8788, la n-(2-pyridinylméthyl)-n'-[3-((2-naphtalénylméthyl)amino)-propyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8733 et amd8734, la n-(2-pyridinylméthyl)-n'-[2-(s)-pyrolidinylméthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8756, la n-(2-pyridinylméthyl)-n'-[2-( r )-pyrolidinylméthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8799, la n-(2-pyridinylméthyl)-n'-[3-pyrazolylméthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènedïméthanamine ; amd8728, la n-(2-pyridinylméthyl)-n' -[2-pyrrolylméthyl]-n' -(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8836, la n-(2-pyridinylméthyl)-n'-[2-thiophénylméthyl]-n'-(5,6,7,8-têtrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8841, la n-(2-pyridinylméthyl)-n'-[2-thiazolylméthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8821, la n-(2-pyridinylméthyl)-n'-[2-furanylméthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8742, la n-(2-pyridinylméthyl)-n'-[2-[(phénylméthyl)amino]éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8743, la n-(2-pyridinylméthyl)-n'-(2-aminoéthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8753, la n-(2-pyridinylméthyl)-n'-3-pyrrolidinyl-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8754, la n-(2-pyridinylméthyl)-n'-4-pipéridinyl-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8784, la n-(2-pyridinylméthyl)-n'-[2-[(phényl)amino]éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8759, la n-(2-pyridinylméthyl)-n'-(7-méthoxy-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzènediméthanamine; amd8762, la n-(2-pyridinylméthyl)-n'-(6-méthoxy-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzènediméthanamine ; amd8770, la n-(2-pyridinylméthyl)-n'-(1-méthyl-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzènediméthanamine ; amd8790, le n-(2-pyridinylméthyl)-n'-(7-méthoxy-3,4-dihydronaphtalényl)-1-(aminométhyl)-4-benzamide ; amd8805, le n-(2-pyridinylméthyl)-n'-(6-méthoxy-3,4-dihydronaphtalényl)-1-(aminométhyl)-4-benzamide ; amd8902, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-2-ylméthyl)-n'-(7-méthoxy-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzènediméthanamine ; amd8863, la n-(2-pyridinylméthyl)-n'-(8-hydroxy-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzènediméthanamine ; amd8886, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-2-ylméthyl)-n'-(8-hydroxy-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzènediméthanamine ; amd8889, la n-(2-pyridinylméthyl)-n'-(8-fluoro-1,2,3,4-tétrahydro-2-naphtalényl)-1,4-benzênediméthanamïne ; amd8895, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-2-ylméthyl)-n'-(8-fluoro- 1,2,3,4-tétrahydro-2-naphtalênyl)-1,4-benzènediméthanamine ; amd8852, la n-(2-pyridinylméthyl)-n'-(5,6,7,8-tétrahydro-7-quinoléinyl)-1,4-benzènediméthanamine ; amd8858, la n-(2-pyridinylméthyl)-n'-(1 h -imidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-7-quinoléinyl)-1,4-benzènedimêthanamine ; amd8785, la n-(2-pyridinylméthyl)-n'-[2-[(2-naphtalénylméthyl)amino]éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8820, la n-(2-pyridinylméthyl)-n'-[2-(isobutylamino)éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8827, la n-(2-pyridinylméthyl)-n'-[2-[(2-pyridinylméthyl)amino]éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8828, la n-(2-pyridinylméthyl)-n'-[2-[(2-furanylméthyl)amino]éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8772, la n-(2-pyridinylméthyl)-n'-(2-guanidinoéthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8861, la n-(2-pyridinyméthyl)-n'-[2-[bis-[(2-méthoxy)phénylméthyl]-amino]éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8862, la n-(2-pyridinylméthyl)-n'-[2-[(1 h -imidazol-4-ylméthyl)-amino]éthyt]-n'-(5,6,7,8-tétrahydro-8-qumolémyl)-1,4-benzènediméthanamine ; amd8887, la n-(2-pyridinylméthyl)-n'-[2-[(1 h -imidazol-2-ylméthyl)amino]-éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8816, la n-(2-pyridinylméthyl)-n'-[2-(phényluréido)éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8737, la n-(2-pyridinylméthyl)-n'-[[n"-(n-butyl)carboxamido]méthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8739, la n-(2-pyridinylméthyl)-n'-(carboxamidométhyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8752, la n-(2-pyridinylméthyl)-n'-[(n"-phényl)carboxamidométhyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8765, la n-(2-pyridinylméthyl)-n'-(carboxyméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8715, la n-(2-pyridinylméthyl)-n'-(phénylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8907, la n-(2-pyridinylméthyl)-n'-(1 h -benzimidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8927, la n-(2-pyridinylméthyl)-n'-(5,6-diméthyl-1 h -benzimidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine (sel de bromhydrate) ; amd8926, la n-(2-pyridinylméthyl)-n'-(5-nitro-1 h -benzimidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8929, la n-(2-pyridinylméthyl)-n'-[(1 h )-5-azabenzimidazol-2-ylméthyl]-n'-(5,6,7, 8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8931, la n-(2-pyridinylméthyl)-n-(4-phényl-1 h -imidazol-2-ylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8783, la n-(2-pyridinylméthyl)-n'-[2-(2-pyridinyl)éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8764, la n-(2-pyridinylméthyl)-n-(2-benzoxazolyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8780, la n-(2-pyridinylméthyl)-n'-( trans -2-aminocyclohexyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8818, la n-(2-pyridinylméthyl)-n'-(2-phênyléthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8829, la n-(2-pyridinylméthyl)-n'-(3-phénylpropyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8839, la n-(2-pyridinylméthyl)-n'-( trans -2-aminocyclopentyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8726, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)glycinamide ; amd8738, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-(l)-alaninamide ; amd8749, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-(l)-aspartamide; amd8750, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydra-8-quinoléinyl)pyrazinamide ; amd8740, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-(l)-prolinamide ; amd8741, le n-[[4-[[2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-(l)-lysinamide ; amd8724, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)benzamide ; amd8725, le n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]méthyl]-n-(5,6,7,8-tétrahydro-8-quinoléinyl)picolinamide ; amd8713, la n'-benzyl-n-[[4-[[(2-pyridinylméthyl)amino]méthyl]phényl]-méthyl-n-(5,6,7,8-tétrahydro-8-quinoléinyl)urée ; amd8712, la n'-phényl-n-[[4-[[2-pyridinylméthyl)amino]méthyl]phényl]-méthyl-n-(5,6,7,8-tétrahydro-8-quinoléinyl)urée ; amd8716, le n-(6,7,8,9-tétrahydro-5 h -cydohepta[ b ]pyridin-9-yl)-4-[[(2-pyridinylméthyl)amino]méthyl]benzamide ; amd8717, le n-(5,6,7,8-tétrahydro-8-quinoléinyl)-4-[[(2-pyridinylméthyl)-amino]méthyl]benzamide ; amd8634, la n,n'-bis(2-pyridinylméthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine : amd8774, la n,n'-bis(2-pyridinylméthyl)-n'-(6,7,8,9-tétrahydro-5 h- cyelohepta[ b ]pyridin-9-yl)-1,4-benzénediméthanamine ; amd8775, la n,n'-bis(2-pyridinylméthyl)-n'-(6,7-dihydro-5 h -cyclopenta-[ b ]pyridin-7-yl)-1,4-benzènediméthanamine ; amd8819, la n,n'-bis(2-pyridinylméthyl)-n'-(1,2,3,4-tétrahydro-1-naphtalényl)-1,4-benzénediméthanamine ; amd8768, la n,n'-bis(2-pyridinylméthyl)-n'-[(5,6,7,8-tétrahydro-8-quinoléinyl)méthyl]-1,4-benzénediméthanamine ; amd8767, la n,n'-bis(2-pyridinylméthyl)-n'[(6,7-dihydro-5 h -cyclopenta-[ b ]pyridin-7-yl)méthyl]-1,4-benzènediméthanamine ; amd8838, la n-(2-pyridinylméthyl)-n-(2-méthoxyéthyl)-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd8871, la n-(2-pyridinylméthyl)-n-[2-(4-méthoxyphényl)éthyl]-n'-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzénediméthanamine ; amd8844, la n,n'-bis(2-pyridinylméthyl)-1,4-(5,6,7,8-tétrahydro-8-quinoléinyl)benzènediméthanamine ; amd7129, la n-[(2,3-diméthoxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7130, la n,n'-bis(2-pyridinylméthyl)-n-[1-(n"-phényl-n"-méthyluréido)-4-pipéridinyl]-1,3-benzènediméthanamine ; amd7131, la n,n'-bis(2-pyridinylméthyl)-n-[n"-p-toluènesulfonyl-phénylalanyl)-4-pipéridinyl]-1,3-benzènediméthanamine ; amd7136, la n,n'-bis(2-pyridinylméthyl)-n-[1-[3-(2-chlorophényl)-5-méthylisoxazol-4-oyl]-4-pipéridinyl]-1,3-benzènedïméthanamine ; amd7138, la n-[(2-hydroxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7140, la n-[(4-cyanophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzénediméthanamine ; amd7141, la n-[(4-cyanophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7142, la n-[(4-acétamidophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzénediméthanamine ; amd7145, la n-[(4-phénoxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7147, la n-[(1-méthyl-2-carboxamido)éthyl]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7151, la n-[(4-benzyloxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzénediméthanamine ; amd7155, la n-[(thiophén-2-yl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7156, la n-[1-(benzyl)-3-pyrrolidinyl]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7159, la n-[[1-méthyl-3-(pyrazol-3-yl)]propyl]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7160, la n-[1-(phényl)éthyl]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7164, la n-[(3,4-méthylènedioxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7166, la n-[1-benzyl-3-carboxyméthyl-4-pipéridiny1]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7167, 1a n-[(3,4-méthylènedioxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7168, la n-(3-pyridinylméthyl)-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7169, la n-[[1-méthyl-2-(2-tolyl)carboxamido]éthyl]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7171, la n-[(1,5-diméthyl-2-phényl-3-pyrazolinone-4-yl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine; amd7172, la n-[(4-propoxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine; amd7175, la n-(1-phényl-3,5-diméthylpyrazolin-4-ylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyi)-1,4-benzènediméthanamine ; amd7177, la n-[1h-imidazol-4-ylméthyl]-n,n'-bis(2-pyridinylméthyl)-1,3-benzènediméthanamine ; amd7180, la n-[(3-méthoxy-4,5-méthylènedioxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7182, la n-[(3-cyanophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7184, la n-[(3-cyanophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènedimëthanamine ; amd7185, la n-(5-éthylthiophén-2-ylméthyl)-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7186, la n-(5-éthylthiophén-2-ylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7187, la n-[(2,6-difluorophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7188, la n-[(2,6-difluorophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7189, la n-[(2-difluorométhoxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7195, la n-(2-difluorométhoxyphénylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7196, la n-(1,4-benzodioxan-6-ylméthyl)-n'-(2-pyridinylméthyl)-n-(6,7,8,9-tétrahydro-5 h -cyclohepta[ b ]pyridin-9-yl)-1,4-benzènediméthanamine ; amd7197, la n,n'-bis(2-pyridinylméthyl)-n-[1-(n"-phényl-n"-méthyluréido)-4-pipéridinyl]-1,4-benzènediméthanamine ; amd7198, la n,n'-bis(2-pyridinylméthyl)-n-[n"-p-toluènesulfonylphénylalanyl)-4-pipéridinyl]-1,4-benzènediméthanamine ; amd7199, la n-[1-(3-pyridinecarboxamido)-4-pipéridinyl]-n,n'-bis(2-pyridinylméthyl)-1,4- benzènediméthanamine ; amd7200, la n-[1-(cyclopropylcarboxamido)-4-pipéridinyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7201, la n-[1-(1-phénylcyclopropylcarboxamido)-4-pipéridinyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènedimëthanamine ; amd7202, la n-(1,4-benzodioxan-6-ylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7203, la n-[1-[3-(2-chlorophényl)-5-méthylisoxazol-4-carboxamido]-4-pipéridinyl)-n,n'-bis(2-pyridinylméthyl)-1 ,4-benzènediméthanamine ; amd7204, la n-[1-(2-thiométhylpyridine-3-carboxamido)-4-pipéridinyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7207, la n-[(2,4-difluorophényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7208, la n-(1-méthylpyrrol-2-ylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7209, la n-[(2-hydroxyphényl)méthyl]-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7212, la n-[(3-méthoxy-4,5-méthylènedioxyphényl)méthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7216, la n-(3-pyridinylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4- benzènediméthanamine ; amd7217, la n-[2-(n"-morpholinométhyl)-1-cyclopentyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7220, la n-[(1-méthyl-3-pipéridinyl)propyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7222, la n-(1-méthylbenzimidazol-2-ylméthyl)-n'-(2-pyridinylméthyl)-n-(5,6,7,8-tétrahydro-8-quinoléinyl)-1,4-benzènediméthanamine ; amd7223, la n-[1-(benzyl)-3-pyrrolidinyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7228, la n-[[(1-phényl-3-(n"-morpholino)]propyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7229, n-[1-(isopropyl)-4-pipéridinyl]-n,n'-bis(2-pyridinylméthyl)-1,4-benzènediméthanamine ; amd7230, la n-[l-(éthoxycarbonyl)-4-pipéridinyl]-n&

Inglês

a compound as claimed in claim 1, wherein said compound is amd7490, n-(2-pyridinylmethyl)-n'-(6,7,8,9-tetrahydro-5 h- cyclohepta[ b ]pyridin-9-yl)-1,4-benzenedimethanamine; amd7491, n-(2-pyridinylmethyl)-n'-(5,6,7,8,-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7492,n-(2-pyridinylmethyl)-n'-(6,7-dihydro-5 h -cyclopenta[ b ]pyridin-7-yl)-1,4-benzenedimethanamine; amd8766,n-(2-pyridinylmethyl)n'-(1,2,3,4-tetrahydro-1-naphthalenyl)1,4-benzenedimethanamine; amd87s9,n-(2-pyridinylmethyl)-n'-(1-naphthalenyl)-1,4-benzenedimethanamine; amd8776, n-(2-pyridinylmethyl)-n'-(8-quinolinyl)-1,4-benzenedimethanamine; amd8859, n-(2-pyridinylmethyl)-n'-[2-[(2-pyridinylmethyl)amino]ethyl]-n'-(1-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8867, n-(2-pyridinylmethyl)-n'-[2-[(1 h -imidazol-2-ylmethyl)amino]ethyl]-n'-(1-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-1,4-benzene dimethanamine; amd8746, n-(2-pyridinylmethyl)-n'-(1,2,3,4-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8835, n-(2-pyridinylmethyl)-n' -[2-[(1 h-imidazol-2- ylmethyl)amino]ethyl]-n'-(1,2,3,4-tetrahydro-1-naphthalenyl)-1,4-benzene dimethanamine; amd8833, n-(2-pyndinylmethyl)-n'-(2-pheayl-5,6.7.8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8825,n,n'-bis(2-pyridinylmethyl)-n'-(2-phenyl-5,6,7,8-tetrahydro-8-quinolinyl)1,4-benzenedimethanamine; amd8869, n-(2-pyndinylmethyl)-n'-(5,6,7,8-tetrahydro-5-quinolinyl)-1,4-benzenedimethanamine; amd8876,n-(2-pyrudinymelthyl)-n'-(1 h -imidazol-2-ylmethyl)-n'-(5,6,7,8-tetrahydro-5-quinolmy!)-1,4-beazenedimethaiiamine; amd8751, n-(2-pyridinylmethyl)-n'-(1 h -imidazol-2-ylmethyl)-n,-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8777, n-(2-pyridinylmethyl)-n'-[(2-amino-3 phenyl)propyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8763, n-(2-pyridinylmethyl)-n'-(1 h -imidazol-4-ylmethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8771, n-(2 pyidinylmethyl)-n'-(2-quinolinylmethyl)-n'-5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd78778, n-(2-pyridinylmethyl)-n'-(2-(2-naphthoyl)aminoethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd9791, n-(2-pyridinylmethyl)-n'-[(s)-(2-acetylamino-3-pheny)propyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8792, n-(2-pyridinylmethyl)-n,-[( s )-(2-acetylamino-3-phenyl)propyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd9788, n-(2-pyridinylmethyl)-n'-[3-((2-naphthalenylmethyl)amino)propyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; and9733 and amd8734, n-(2-pyridinylmethyl)-n-[2-( s )-pyrollidinylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8756, n-(2-pyridinylmethyl)-n'-[2-( r )-pyrollidinylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8799, n-(2-pyridinylmethyl)-n'-[3-pyrazolylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8728, n-(2-pyridinylmethyl)-n'-[2-pyrrolylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8s36, n-(2-pyridinylmethyl)-n'-[2-thiopheneylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine amd8841, n-(2-pyridinylmethyl)-n'-[2-thiazolylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8821, n-(2-pyridinylmethyl)-n'-[2-furanylmethyl]-n'-(5,6,7,8-tetrahydco-8-quinolinyl)-1,4-benzenedimethanamine; amd8742, n-(2-pyridinylmethyl)n'-[2-[(phenylmethyl)amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8743, n-(2-pyridinylmethyl)-n'-(2-aminoethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8753,n-(2-pyridinylmethyl)-n'-3-pyrrolidinyl-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-beazenedimethanamine amd8754, n-(2-pyridinylmethyl)-n'-4-piperidinyl-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8784, n-(2-pyridinylmethyl)-n'-[2-[(phenyl)amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8759, n-(2-pyrindinylmethyl)-n'-(7-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8762, n-(2-pyridinylmethyl)-n'-(6-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8770, n-(2-pyridinylmethyl)-n'-(1-methyl-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; and8790, n-(2-pyridinylmethyl)-n'-(7-methoxy-3,4-dihydronaphthalenyl)-1-(aminomethyl)-4-benzamide; amd8805, n-(2-pyridinylmethyl)-n'-(6-methoxy.3,4-dyhidronaphthalenyl)-1-(aminomethyl)-4-benzamide; and8902, n-(2-pyrridinylmethyl)-n'-(1 h -imidazol-2-ylmethyl)-n'-(7-methaxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8863, n-(2-pyridinylmethyl)-n'-(8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8886, n-(2-pyridinylmethyl)-n'-(1 h -imidazol-2-ylmethyl)-n'-(8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8889, n-(2 gyudinylmethyl)-n'-(8-fluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8895, n-(2-pyridinylmethyl)-n' -(1 h -imidazol-2-ylmethyl)-n'-(8-fluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine; amd8852, n -(2-pyridinylmethyl)-n'-(5,6,7,8-tetrahydro-7-quinolinyl)-1,4-benzenedimethanamine; amd8858, n-(2-pyridinylmethyl)-n'-(1h-imidazol-2-ylmethyl)-n'-(5,6,7,8-tetrahydro-7-quinolinyl)-1,4-benzenedimethanamine; amd8785, n-(2-pyridinylmethyl)-n'-[-[(2-naphthalenylmethyl) amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethianamine amd8820, n-(2-pyridinylmethyl)-n'-[2-(isobutylamino)ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8827, n-(2-pyridinylmethyl)-n'-[2-[(2-pyridinylmethyl)amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8828, n-(2-pyridinylmethyl)-n'-[2-[(2-furanylmethyl)amino]ethyl']-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8772, n-(2-pyridinylmethyl)-n'-(2-guanidinoethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8861, n-(2-pyridinylmethyl)-n'-[2-[bis-[(2-methoxy)phenylmethyl]amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzene dimethanamine; amd8862, n-(2-pyridinylmethyl)-n'-(2-[(1 h -imidazol-4-ylmethyl)amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-qunolinyl)-1,4-benzene dimethanamine; amd8887, n-(2-pyridinylmethyl)-n'-[2-[(1 h -imidazol-2-ylmethyl)amino]ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8816, n-(2-pyridinylmethyl)-n'-[2-(phenylureido)ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8737, n-(2-pyridinylmethyl)-n'-[[n"-(n-butyl)carboxamido]methyl] -n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8739, n-(2-pyridinylmethyl)-n'-(carbvxamidomethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8752, n-(2-pyridinylmethyl)-n'-[(n"-phenyl)carboxamidomethyl]-n'-(5,6,7,8-tetrahydro-8-qninolinyl)-1,4-benzenedimethanamine; amd8765, n-(2-pyridinylmethyl)-n'-(carboxymethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethacamine; amd871 5, n-(2-pyridinylmethyl)-n'-(phenylmethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8907, n-(2-pyridinylmethyl)-n'-(1 h -benzimidazol-2-ylmethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8927, n-(2-pyridinylmethyl)-n'-(5,6-dimethyl-1 h -benzimidazol-2-ylmethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine (hydrobromide salt); amd8926. n-(2-pyridinylmethyl)-n'-(5-nitro-1 h -benzimidazol-2-ymethyl)-n'-(5,6,7,9-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8929, n-(2-pyridinylmethyl)-n'-[(1 h )-5-azabenzimidazol-2-ylmethyl]-n'-(5,6,7,8-tetrahydro-8-quinoliny)-1,4-benzenedimethanamine; amd8931, n-(2-pyrldinylmethyl)n-(4-phenyl-1 h -imidazol-2-ylmethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8783, n-(2-pyridinylmethyl)-n'-[2-(2-pyridinyl)ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd3764, n-(2-pyridinylmethyl)-n'-(2-benzoxazolyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8780, n-(2-pyridinylmethyl)-n'-( trans- 2-aminocyclohexyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8818, n-(2-pyridinylmethyl)-n'-(2-phenylethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8829, n-(2-pyridinylmethyl)n'-(3-phenylpropyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8839, n-(2-pyridinylmethyl)-n'-( trans -2-aminocyclopentyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8726, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tehahydro-8-quinolinyl)-glycinamide; amd8738, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-(l)-alaninamide; amd8749, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl[methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-(l)-aspartamide; amd8750, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-pyrazinamide; amd8740, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-(l)-prolinamide; amd8741, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-(l)-lysmamide; amd8724, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-benzamide; amd8725, n-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-picolinamide; amd8713, n'-benzyl-n-[[4-[[(2-pyridinylmethyl) amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahydro-8-quinolinyl)-urea; amd8712, n'-phenyl-n-[[4-[[(2-pyridinylmethyl) amino]methyl]phenyl]methyl]-n-(5,6,7,8-tetrahyro-8-quinolinl)-urea; amd8716, n-(6,7,8,9-tetrahydro-5 h -cyclohepta[b]pyridin-9-yl)-4-[[(2-pyridinylmethyl)amino]methyl]benzamide; amd8717, n-(5,6,7,8-tetrahydro-8-quinolinyl)-4-[[(2-pyridinylmethyl)amino]methyl]benzamide; amd8634, nn'-bis(2-pyridinylmethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8774, n,n' -bis(2-pyridinylmethyl)-n'-(6.7,8,9-tetrahydro-5 h- cyclohepta[ b ]pyridin-9-yl)-1,4-benzenedimethanamine; amd8775, n,n'-bis(2-pyridinylmethyl)-n'-(6,7-dihydro-5 h- cyclopenta[ b ]pyndin-7-yl)-1,4-benzenedimethanamine; amd8819, n,n'-bis(2-pyridinylmethyl)-n,-(1,2,3,4-tetrahydro-1-naphthalenyl)-1,4-benzenedimethanamine; amd8768,n,n'-bis(2-pyridinylmethyl)-n'-[(5,6,7,8-tetrahydro-8-quinolinyl)methyl]-1,4-benzenedimethanamine; amd8767,n,n'-bis(2-pyrridinylmethyl)-n'[(6,7-dihydro)-5 h- cyclopenta[ b ]pyridin-7-yl)methyl]-1,4-benzenedimethanamine; amd8838,n-(2-pyridinylmethyl)-n-(2-methoxyethyl)-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd8871,n-(2-pyridinylmethyl)-n-[2-(4-methoxyphenyl)ethyl]-n'-(5,6,7,8-tetrahydro-8-quinolinyl)-4-benzenedimethanamine; amd8844, n,n'-bis(2-pyridinylmethyl)-1,4-(5,6,7,8-tetrahydro-8-quinolinyl)benzenedimethanamine; amd7129, n-[(2,3-dimethoxyphenyl)methyl]-n'-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7130, n,n'-bis(2-pyridinylmethyl)-n-[1-(n"-phenyl-n"-methylmeido)-4-piperidinyl]-1,3-benzenedimethanamine; amd7131, n,n'-bis(2-pyridinylmethyl)-n-[n"-p-toluenesulfonylphenylalanyl)-4-piperidinyl]-1,3-benzenedimethanamine; amd7136, n,n'-bis(2-pyridinylmethyl)-n-[1-[3-(2-chlorophenyl)-5-methyl-isoxazol-4-oyl]-4-piperidinyl]-1,3-benzenedimethanamine; amd7138, n-[(2-hydroxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7140, n-[(4-cyanophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7141, n-[(4-cyanophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7142, n-[(4-acetamidophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7145,n-[(4-phenoxyphenyl)methyl]-n'-(2-pyndinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclobepta[b]pyridin-9-yl)-1,4-bemenedimethanamine; amd7147, n-[(1-methyl-2-carboxemido)ethyl]-n,n'-bis(2-pyridinylmethyl)-1,3-benzenedimethanamine; an1d7151, n-[(4-benzyloxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7155, n-[(thiophene-2-yl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7156 n-[1-(benzyl)-3-pyrrolidinyl]-n,n'-bis(2-pyridinylmethyl)-1,3-benzenedimethanamine; amd7159,n-[[1-methyl-3-(pyrazol-3-yl)]propyl]-n,n'-bis(2-pyridinylmethyl)-1,3-benzenedimethanamine; amd7160, n-[1-(phenyl)ethyl]-n,n'-bis(2-pyridinylmethyl)-1,3-benzenedimethanamine; amd7164, n-[(3,4-methylenedioxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7166, n-[1-benzyl-3-carboxymethyl-4-piperidinyl]-n,n'-bis(2-pyridinylmethyl)-1,3-benzenedimethanamine; amd7167, n-[(3,4-methylenedioxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5.6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7168, n-(3-pyridinylmethyl)-n'-(2-pyridinylmethyl)-n-(6,7,9,9-tetrahydro-5h-cyclohepta[b]pyndin-9-yl)-1,4-benzenedimethanamine; amd7169, n-[[1-methyl-2-(2-tolyl)carboxamido]ethyl]-n,n'-bis(2-pyridinylmethyl)-1,3-benzenedimethanamine; amd7171, n-[(1,5-dilethyl-2-phenyl-3-pyrazolinone-4-yl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-quinolinyl)-1,4-benzenedimethanamine; amd7172, -n-[(4-propoxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahycho-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7175, n-(1-phenyl-3,5-dimethylpyrazolin-4-ylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7177, n-[1 h -imidazo-4-ylmethyl]-n,n'-bis(2-pyridinylmethyl)-1.3-benzenedimethanamine; amd7180, n-[(3-methoxy-4,5-methylenedioxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cycloheptal[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7182, n-[(3-cyanophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7184, n-[(3-cyanophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7185, n-(5-ethylthiophene-2-ylmethyl)-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridina-9-yl)-1,4-benzenedimethanamine; amd7186, n-(5-ethylthiophene-2-ylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8quinolinyl)-1,4-benzenedimethanemine; amp7187, n-[(2, 6-diafluorophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-tenzenedimethanamine; amd7188,n-[(2,6-difluorophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzeaedimethanamine; amd7189, n-[(2-difluoromethoxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedilnethanamine; amd7195, n-(2-difluoromethoxyphenylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7196, n-(1,4-benzodioxen-6-ylmethyl)-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7197, n, n'-bis(2-pyridinylmethyl)-n-[1-(n"-phenyl-n"-methylureido)-4-piperidinyl]-1,4-beazenedimethanamine; amd7198, n, n'-bis(2-pyridinylmethyl)-n-[n"-p-toluenesulfonylphenylalanyl)-4-piperidinyl]-1,4-benzenedimethanamine; amd7199, n-[1-(3-pyridinecarboxamido)-4-piperidinyl]-n,n'-bis(2-pyridinylimethyl)-1,4-benzenedimethanamine; amd7200, n-[1-(cyclopropylcarboxamido)4-piperidinyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethenamine; amd7201, n-[1-(1-phenylcyclopropylcarboxamido)-4-piperidinyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine.; amd7202, n-(1,4-benzodioxan-6-ylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7203, n-[1-[3-(2-chlorophenyl)-5-methyl-isoxazol-4-carboxamido-4-piperidinyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine: amd7204, n-[1-(2-thiomethylpyridine-3-carboxamido)-4-piperidinyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine; amd7207, n-[(2,4-difluorophenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7208, n-(1-methylpyrrol-2-ylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine, amd7209, n-[(2-hydroxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7212, n-[(3-methoxy-4,5-methylenedioxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7216, n-(3-pyridinylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7217, n-[2-(n"-morpholinomethyl)-l-cyclopentyl]-n,n'-bis(2-pyndinylmethyl)-1,4-benzenedimethanamine; amd7220, n-[(1-methyl-3-piperidirtyl)propyl]-n,n'-bis(2-pyridimylmethyl)-1,4-benzenedimethanainine; amd7222, n-(1-methylbenzimidazol-2-ylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimetbanamine; amd7223, n-[1-(benzyl)-3-pymolidinyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine; amd7228, n-[[(1-phenyl- 3-(n"-morpholino)]propyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzene umethanaming; amd7229, n-[1-(iso-propyl)-4-piperidinyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine; amd7230, n-[1-(ethoxycarbonyl)-4-piperidinyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenadimethanamine; amd7231, n-[(1-methyl-3-pyrazolyl)propyl]-n'-(2-pyridinylmethyl)-n-(5.6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7235,n-[1-methyl-2-(n",n"-diethylvcarbonamide)ethyl]-n,n'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine: amd7236, n-[(1-methyl-2-phenylsulfonyl)ethyl]-n"-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7238,n-[(2-chloro)-4,5-methylenadioxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7239,n-[1-methyl-2-[n"-(4-chlorophenyl)carboxamido]ethyl]-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7241,n-(1-acetoxyindol-3-ylmethyl)-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7242, n-[(3-benzyloxy-4-methoxyphenyl)methyl]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7244, n-(3-quinolylmethyl)-n'-(2-pyridinylmethyl)-n-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; amd7245,n-[(8-hydroxy)-2-quinolylmethy]-n'-(2-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedilmthanamine; amd7247,n-(2-quinolylmethyl)-n'-(2-pyridinylmethyl)-n-(6,7,9,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzedimethanamine; amd7249, n-[(4-acetamidophenyl)methyl]-n'-9-pyridinylmethyl)-n-(6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; amd7250,n-[1h-imid

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Aviso: contém formatação HTML invisível

Francês

composé selon la revendication 1, à savoir : la 3-[(3-hydroxypropyl)thio]-5-méthyl-7-(2-méthyl-2-propényl)-2-(1-naphtalénylméthyl)-2h-pyrazolo[3,4-d]-pyrimidine-4,6[5h,7h]-dione, ou la 5-méthyl-7-(2-méthyl-2-propényl)-2-(1-naphtalénylméthyl)-3-[(2-pyridinyl)thio]-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, ou la 3-[(2-hydroxyéthyl) thio]-5-méthyl-7- (2-méthyl-2-propényl)-2-(1-naphtalénylméthyl)-2h-pyrazolo[3,4-d]-pyrimidine-4,6[5h,7h]-dione, ou la 3-(4-hydroxybutyl)-5-méthyl-7-(2-méthylpropyl)-2-(1-naphtalénylméthyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, ou la 5-méthyl-7-(2-méthylpropyl)-2-(1-naphtalénylméthyl)-3-propylthio-2h-pyrazolo[3, 4-d]pyrimidine-4, 6[5h,7h]-dione, ou la 3-[(3-hydroxypropyl)thio]-5-méthyl-7-(2-méthylpropyl)-2-(1-naphtalénylméthyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, ou l'acide méthyl-4-[(4,5,6,7-tétrahydro-5-méthyl-7-{2-méthylpropyl}-2-{1-naphtalénylméthyl}-4, 6-dioxo-2h-pyrazolo[3,4-d]pyrimidin-3-yl)thio]butanoïque, ou l'acide 4-[(4,5,6,7-tétrahydro-5-méthyl-7-{2-méthylpropyl}-2-{1-naphtalénylméthyl}-4,6-dioxo-2h-pyrazolo[3,4-d]pyrimidin-3-yl)thio]butanoïque, ou la 3-[(3-hydroxypropyl)thio]-5-méthyl-7-(2-méthylpropyl)-2-(2-{phénylsulfonylméthyl}phénylméthyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, ou la 2-({5-chlorobenzo[1,3]dioxol-6-yl}méthyl)-3-[(3-hydroxypropyl)thio]-5-méthyl-7-(2-méthylpropyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, ou la 2-(3-chloro-2-fluorophénylméthyl)-3-[(3-hydroxypropyl)thio]-5-méthyl-7-(2-méthylpropyl)-2h-pyrazolo[3,4-d]pyrimidine-4, 6[5h,7h]-dione, ou la 3-[(3-hydroxypropyl)thio]-5-méthyl-7-(2-méthylpropyl)-2-(2-quinoléinylméthyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, ou un sel pharmaceutiquement acceptable de l'un quelconque d'entre eux.

Inglês

a compound according to claim 1 which is: 3-[(3-hydroxypropyl)thio]-5-methyl-7-(2-methyl-2-propenyl)-2-(1-naphthalenylmethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, or 5-methyl-7-(2-methyl-2-propenyl)-2-(1-naphthalenylmethyl)-3-[(2-pyridinyl)thio]-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, or 3-[(2-hydroxyethyl)thio)-5-methyl-7-(2-methyl-2-propenyl)-2-(1-naphthalenylmethyl-2h-pyrazolo[3,4-d]pyrimidine-4,6[5h,7h]-dione, or 3-(4-hydroxybutyl)-5-methyl-7-(2-methylpropyl)-2-(1-naphthalenylmethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or 5-methyl-7-(2-methylpropyl)-2-(1-naphthalenylmethyl)-3-propylthio-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or 3-[(3-hydroxypropyl)thio]-5-methyl-7-(2-methylpropyl)-2-(1-naphthalenylmethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or methyl 4-[(4,5,6,7-tetrahydro-5-methyl-7-{2-methylpropyl}-2-{1-naphthalenyl-methyl }-4,6-dioxo-2h-pyrazolo[3,4-d]pyrimidin-3-yl)thio]butanoic acid, or 4-[(4,5,6,7-tetrahydro-5-methyl-7- {2-methylpropyl}-2- {1-naphthalenylmethyl}-4,6-dioxo-2h-pyrazolo[3,4-d]pyrimidin-3-yl)thio]butanoic acid, or 3-[(3-hydroxypropyl)thio]-5-methyl-7-(2-methylpropyl)-2-(2-{phenyl-sulfonylmethyl}phenylmethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or 2-( {5-chlorobenzo[1,3]dioxol-6-yl}methyl)-3-[(3-hydroxypropyl)thio]-5-methyl-7-(2-methylpropyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or 2-(3-chloro-2-fluorophenylmethyl)-3-[(3-hydroxypropyl)thio]-5-methyl-7-(2-methylpropyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or 3-[(3-hydroxypropyl)thio]-5-methyl-7-(2-methylpropyl)-2-(2-quinolinylmethyl)-2h-pyrazolo[3,4-d]pyrimidine-4,6(5h,7h)-dione, or a pharmaceutically acceptable salt of any one thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé selon la revendication 4, dans lequel : z est le groupe éthanoyle, -c(o)cf 3 ou -s(o) 2 -ch 3 ; et r 2a est le groupe phényle, p-fluorophényle, phénylméthyle, naphtyle, naphtylméthyle, pyridyle, quinoléinyle, quinoléinylméthyle ou n-méthyltétrazolyle ; ou l'un de ses sels acceptables d'un point de vue pharmaceutique.

Inglês

a compound according to claim 4 wherein: z is ethanoyl -c(o)cf 3 , or -s(o) 2 -ch 3 ; and r 2a is phenyl, p -fluorophenyl, phenylmethyl, naphthyl, naphthylmethyl, pyridyl, quinolinyl, quinolinylmethyl or n-methyltetrazolyl; or a pharmaceutically acceptable salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé selon la revendication 1, dans lequel r 1 est un groupe phényle, benzyle, 1-naphtylméthyle, 2-naphtylméthyle, pyridyle, pyridylméthyle, quinoléinyle ou quinoléinylméthyle, dont l'un quelconque est éventuellement substitué par 1 à 5 substituants parmi les groupes chloro, méthoxy, méthyle, trifluorométhyle, cyano, nitro, méthylsulfonyle, amino ou diméthylamino.

Inglês

a compound of claim 1, wherein r 1 is phenyl, benzyl, 1-naphtylmethyl, 2-naphthylmethyl, pyridyl, pyridylmethyl, quinolinyl or quinolinylmethyl, any of which is optionally substituted by 1-5 of chloro, methoxy, methyl, trifluoromethyl, cyano, nitro, methylsulfonyl, amino or dimethylamino.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

composé selon la revendication 1, dans lequel r 1 est un groupe 8-quinoléinyle, 5-méthyl-8-quinoléinyle, 8-quinoléinylméthyle, 5-méthyl-8-quinoléinylméthyle, 4-benzo-2,1,3-thiadiazolyle, 5-chloro-2-thiophényle, 5-chloro-1,3-diméthyl-4-pyrazolyle, pyridyle, isoquinoléinyle, pyridylméthyle, isoquinoléinylméthyle, tétrahydroquinoléinyle et tétrahydroquinoléinylméthyle.

Inglês

a compound of claim 1, wherein r 1 is 8-quinolinyl, 5-methyl-8-quinolinyl, 8-quinolinylmethyl, 5-methyl-8-quinolinylmethyl, 4-benzo-2,1,3-thiadiazolyl, 5-chloro-2-thiophenyl, 5-chloro-1,3. dimethyl-4-pyrazolyl, pyridyl, isoquinolinyl, pyridylmethyl, isoquinolinylmethyl, tetrahydroquinolinyl and tetrahydroquinolinylmethyl.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

la (2r*,4s*,1's*)-1-(3,5-diméthylbenzoyl)-2-(1'-hydroxy-1'-phénylméthyl)-n-(4-quinoléinylméthyl)-4-pipéridineamine ou l'un de ses sels.

Inglês

(2r*,4s*,1's*)-1-(3,5-dimethylbenzoyl)-2-(1'-hydroxy-1'-phenylmethyl)-n-(4-quinolinylmethyl)-4-piperidinamine or a salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

la (2r*,4s*,1'r*)-2-{1'-hydroxy-1'-(4-chlorophényl)-méthyl}-1-(3,5-diméthylbenzoyl)-n-(4-quinoléinylméthyl)-4-pipéridineamine ou l'un de ses sels.

Inglês

(2r*,4s*,1'r*)-2-{1'-hydroxy-1'-(4-chlorophenyl)methyl}-1-(3,5-dimethylbenzoyl)-n-(4-quinolinylmethyl)-4-piperidinamine or a salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

la (2r*,4s*,1's*)-1-(3,5-diméthylbenzoyl)-2-{1'-hydroxy-1'-(4-chlorophényl)-méthyl}-n-(4-quinoléinylméthyl)-4-pipéridineamine ou l'un de ses sels.

Inglês

(2r*,4s*,1's*)-1-(3,5-dimethylbenzoyl)-2-{1'-hydroxy-1'-(4-chlorophenyl)-methyl}-n-(4-quinolinylmethyl)-4-piperidinamine or a salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

la (2r*,4s*,1's*)-1-(3,5-diméthylbenzoyl)-2-{1'-hydroxy-1'-(3,4-dlchlorophényl)-méthyl}-n-(4-quinoléinylméthyl)-4-pipéridineamine ou l'un de ses sels.

Inglês

(2r*,4s*,1's*)-1-(3,5-dimethylbenzoyl)-2-{1'-hydroxy-1'-(3,4-dichlorophenyl)-methyl}-n-(4-quinolinylmethyl)-4-piperidinamine or a salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

la (2r*,4s*)-2-(4-chlorobenzyl)-1-(3,5-diméthylbenzoyl)-n-(4-quinoléinylméthyl)-4-pipéridineamine ou l'un de ses sels.

Inglês

(2r*,4s*)-2-(4-chlorobenzyl)-1-(3,5-dimethylbenzoyl)-n-(4-quinolinylmethyl)-4-piperidinamine or a salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

Francês

la (2r*,4s*)-2-(3,4-dichlorobenzyl)-1-(3,5-diméthylbenzoyl)-n-(4-quinoléinylméthyl)-4-pipéridineamine ou l'un de ses sels.

Inglês

(2r*,4s*)-2-(3,4-dichlorobenzyl)-1-(3,5-dimethylbenzoyl)-n-(4-quinolinylmethyl)-4-piperidinamine or a salt thereof.

Última atualização: 2014-12-04
Frequência de uso: 2
Qualidade:

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