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Η θαλιδομίδη είναι επίσης ένα μη- βαρβιτουρικό υπνωτικό ηρεμιστικό κεντρικής δράσης.
data from in vitro studies and clinical trials suggest that the immunomodulatory, anti-inflammatory and anti-neoplastic effects of thalidomide may be related to suppression of excessive tumour necrosis factor-alpha (tnf-α) production, down-modulation of selected cell surface adhesion molecules involved in leukocyte migration and anti-angiogenic activity.