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deze dosis is circa zeven keer lager dan de intraperitoneale ld50 bij muizen en meer dan vijf keer lager dan de noel waargenomen bij katten.
this dose is approximately 7 orders of magnitude lower than the intraperitoneal ld50 in mice and more than 5 orders of magnitude lower than the noel observed in cats.
de noel op basis waarvan de adi wordt berekend, moet echter al naar het geval worden gekozen op basis van de toxicologische of farmacologische effecten.
however the noel to be used for the calculation of the adi should be selected on the basis of toxicological or pharmacological effects as appropriate.
wat duidelijk is, hoekstra zei, is dat 1.034.107 ton kooldioxide-uitstoot vermeden 1997-2005 als gevolg van de noel kempff project.
what’s clear, hoekstra said, is that 1,034,107 metric tons of carbon dioxide emissions were avoided from 1997 to 2005 due to the noel kempff project.
de noel (no observed effect level; waarde waarbij geen effect wordt gezien) komt overeen met concentraties die 23 keer hoger waren dan degene die gevonden werden bij patiënten (7 ng/ml in vergelijking met 0,3 ng/ml, d.w.z. de detectielimiet voor emedastine).
emedastine was found to increase the qt interval in dogs; the noel corresponds to levels 23 fold higher than those found in patients (7 ng/ ml as compared with 0.3 ng/ ml, i. e., the limit of detection for emedastine).
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