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apa ini masih ada
这个还有吗
Última atualização: 2022-02-19
Frequência de uso: 1
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selama persediaan masih ada
applies multiply
Última atualização: 2019-04-18
Frequência de uso: 1
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selama stock masih ada.
while stock is still in stock
Última atualização: 2024-06-09
Frequência de uso: 1
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
Última atualização: 2014-04-24
Frequência de uso: 1
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berlaku selama persediaan masih ada
while supplies last
Última atualização: 2019-04-12
Frequência de uso: 1
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masih ada syarat yang harus dilengkapi
there are still obstacles
Última atualização: 2012-04-22
Frequência de uso: 1
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sekian presentasi dari kami, apakah ada pertanyaan?
with all our presentations, are there any questions?
Última atualização: 2022-06-15
Frequência de uso: 1
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masih berada di episode menunggu
masih berada di episode menunggu
Última atualização: 2024-01-26
Frequência de uso: 1
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okeh, kalau tidak ada pertanyaan, saya akhiri, terima kasih
okay, if there is no question, i end it, thank you
Última atualização: 2022-11-30
Frequência de uso: 2
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biarlah kita merendahkan diri dan menyerah, karena mungkin harapan masih ada
he putteth his mouth in the dust; if so be there may be hope.
Última atualização: 2012-05-06
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dengarkanlah sebentar lagi, dan bersabarlah, masih ada yang hendak kukatakan demi allah
elihu also proceeded, and said,
Última atualização: 2012-05-06
Frequência de uso: 1
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jik ada pertanyaan lebih lanjut, tidak perlu segan untuk bertanya kepada kami.
if you have further questions, there is no need to hesitate to ask us.
Última atualização: 2024-03-15
Frequência de uso: 1
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kami dengan senang hati akan membantu, terima kasih banyak telah menginformasikan kepada kami. jangan segan untuk bertanya kepada kami jika masih ada pertanyaan lebih lanjut.
we will gladly help, thank you very much for informing us. don't hesitate to ask us if you have further questions.
Última atualização: 2024-03-15
Frequência de uso: 1
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pertandingan lain yang dijadwalkan hari rabu masih diadakan, menurut kantor berita nbc.
other games scheduled for wednesday were still held, according to nbc news.
Última atualização: 2020-08-25
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daerah crystal creek, sis barat black range semakin parah - mengungsi sekarang, selama masih ada kesempatan
strictly, a writer and web publisher living in brisbane, provided a lot of information.
Última atualização: 2016-02-24
Frequência de uso: 1
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lalu jahanam menjawab dengan marah kepada mereka, "masih adakah tambahan yang lain dari orang-orang yang zalim itu?"
it will say, "are there any more (to come)?"
Última atualização: 2014-07-03
Frequência de uso: 2
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