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apa ini masih ada
这个还有吗
Última atualização: 2022-02-19
Frequência de uso: 1
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selama persediaan masih ada
applies multiply
Última atualização: 2019-04-18
Frequência de uso: 1
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selama stock masih ada.
while stock is still in stock
Última atualização: 2024-06-09
Frequência de uso: 1
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
Última atualização: 2014-04-24
Frequência de uso: 1
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berlaku selama persediaan masih ada
while supplies last
Última atualização: 2019-04-12
Frequência de uso: 1
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masih ada syarat yang harus dilengkapi
there are still obstacles
Última atualização: 2012-04-22
Frequência de uso: 1
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dia menjawab: "masih ada tambahan?"
it will say, "are there any more (to come)?"
Última atualização: 2014-07-03
Frequência de uso: 2
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Aviso: contém formatação HTML invisível
hbd syg kpn ada yg syg?
when can we meet baby
Última atualização: 2021-03-23
Frequência de uso: 1
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masih berada di episode menunggu
masih berada di episode menunggu
Última atualização: 2024-01-26
Frequência de uso: 1
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biarlah kita merendahkan diri dan menyerah, karena mungkin harapan masih ada
he putteth his mouth in the dust; if so be there may be hope.
Última atualização: 2012-05-06
Frequência de uso: 1
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semangat ya kk walaupun gak ada yg komen
the spirit of yes kk even though there is no comment
Última atualização: 2024-04-25
Frequência de uso: 2
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dengarkanlah sebentar lagi, dan bersabarlah, masih ada yang hendak kukatakan demi allah
elihu also proceeded, and said,
Última atualização: 2012-05-06
Frequência de uso: 1
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sebaiknya kalau sudah ada yg haus silakan minum
it's better if someone is thirsty please drink
Última atualização: 2021-09-21
Frequência de uso: 1
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cek ig kita ya mungkin ada yg dibutuhkan, kami free konsultasi
check our ig ya sis
Última atualização: 2018-04-04
Frequência de uso: 1
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sudah tamat kuliah kenapa masih ada bimbingan sama dosen lagi agar bisa diperbolehkan jilid skripsi ??
already graduated from college why there is still the same guidance teacher again?
Última atualização: 2010-10-28
Frequência de uso: 1
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daerah crystal creek, sis barat black range semakin parah - mengungsi sekarang, selama masih ada kesempatan
strictly, a writer and web publisher living in brisbane, provided a lot of information.
Última atualização: 2016-02-24
Frequência de uso: 1
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jangan terlalu nyaman dengan keadaan yg berpihak dengamu
Última atualização: 2020-05-26
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soalnya dulu itu ada yg umurnya 24an ngedm aku mau jadi sugarbaby dia bilang "aku duda belum punya anak"
because there used to be a guy in his 24s.
Última atualização: 2020-11-06
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Aviso: contém formatação HTML invisível
@rikamnis:begini ceritanya kk nya menangis karna saat hari bahagia nya adek nya tapi orang tua nya gak ada yg hadir
who is patient yes
Última atualização: 2024-08-05
Frequência de uso: 1
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lalu jahanam menjawab dengan marah kepada mereka, "masih adakah tambahan yang lain dari orang-orang yang zalim itu?"
it will say, "are there any more (to come)?"
Última atualização: 2014-07-03
Frequência de uso: 2
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Aviso: contém formatação HTML invisível