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selama persediaan masih ada
applies multiply
Última atualização: 2019-04-18
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berlaku selama persediaan masih ada
while supplies last
Última atualização: 2019-04-12
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apa ini masih ada
这个还有吗
Última atualização: 2022-02-19
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
Última atualização: 2014-04-24
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diatas langit masih ada langit
above the sky there is another sky
Última atualização: 2021-04-12
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masih ada syarat yang harus dilengkapi
there are still obstacles
Última atualização: 2012-04-22
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dia menjawab: "masih ada tambahan?"
it will say, "are there any more (to come)?"
Última atualização: 2014-07-03
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masih berada di episode menunggu
masih berada di episode menunggu
Última atualização: 2024-01-26
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biarlah kita merendahkan diri dan menyerah, karena mungkin harapan masih ada
he putteth his mouth in the dust; if so be there may be hope.
Última atualização: 2012-05-06
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dengarkanlah sebentar lagi, dan bersabarlah, masih ada yang hendak kukatakan demi allah
elihu also proceeded, and said,
Última atualização: 2012-05-06
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wabah virus covid 19 masih ada saat ini, covid 19 awalnya berasal dari china
the covid 19 virus outbreak still exists today, covid 19 originally came from china
Última atualização: 2022-03-23
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sudah tamat kuliah kenapa masih ada bimbingan sama dosen lagi agar bisa diperbolehkan jilid skripsi ??
already graduated from college why there is still the same guidance teacher again?
Última atualização: 2010-10-28
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pertandingan lain yang dijadwalkan hari rabu masih diadakan, menurut kantor berita nbc.
other games scheduled for wednesday were still held, according to nbc news.
Última atualização: 2020-08-25
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lalu jahanam menjawab dengan marah kepada mereka, "masih adakah tambahan yang lain dari orang-orang yang zalim itu?"
it will say, "are there any more (to come)?"
Última atualização: 2014-07-03
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Aviso: contém formatação HTML invisível