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ribonucleotide reductase inhibition with reduction of cellular deoxynucleotide triphosphate (dntp) pools.
hæmning af ribonukleotidreduktase med reduktion af cellulære deoxynukleotidphosphat-pools (dntp-pools).
furthermore, cdatp inhibits ribonucleotide reductase, the enzyme responsible for the conversion of ribonucleotides into deoxyribonucleotides.
desuden hæmmer cdatp reduktasen af ribonukleotid, det enzym, der er ansvarlig for omdannelsen af ribonukleotider til deoxyriboneukleotider.
in addition hydroxycarbamide causes an immediate inhibition of dna synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or protein.
desuden medfører hydroxycarbamid en direkte hæmning af dna- syntesen ved at fungere som en hæmmer af ribonukleotidreduktase uden at forstyrre syntesen for ribonukleinsyre eller - protein.
calcium 5'-ribonucleotide is essentially a mixture of calcium inosine-5'-monophosphate and calcium guanosine-5'-monophosphate
calcium-5'-ribonucleotid er i hovedsagen en blanding af calciuminosin-5'-monophosphat og calciumguanosin-5'-monophosphat
in addition, clofarabine possesses greater resistance to cellular degradation by adenosine deaminase and decreased susceptibility to phosphorolytic cleavage than other active substances in its class whilst the affinity of clofarabine triphosphate for dna polymerase and ribonucleotide reductase is similar to or greater than that of deoxyadenosine triphosphate.
endvidere besidder clofarabin større modstandsevne over for cellulær nedbrydning af adenosin- deaminase og mindre modtagelighed for phosphorolytisk spaltning end andre aktive stoffer i denne klasse, mens clofarabintriphosphats affinitet til dna-polymerase and ribonukleotidreduktase svarer til eller overstiger affiniteten til deoxyadenosintriphosphat.
in vitro studies have shown that pemetrexed behaves as a multitargeted antifolate by inhibiting thymidylate synthase (ts), dihydrofolate reductase (dhfr), and glycinamide ribonucleotide formyltransferase (garft), which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotides.
in vitro-forsøg har vist, at pemetrexed fungerer som et bredspektret anti-folat ved at hæmme thymidylatsyntase (ts), dihydrofolatreduktase (dhfr) og glycinamidribonucleotidformyltransferase (garft), som er folatafhængige nøgleenzymer i forbindelse med de novo-biosyntesen af thymidin og purinnukleotider.
