Você procurou por: alkylphosphonothioates (Inglês - Francês)

oligonucleotide alkylphosphonothioates
alkylphosphonothioates oligonucleotidiques

oligonucleotide alkylphosphonates and alkylphosphonothioates
alkylphosphonates et alkylphosphonothioates d'oligonucleotides

the oligonucleotide analog of claim 2 having from 7 to 10 alkylphosphonothioates.
analogue oligonucléotidique selon la revendication 2, comportant de 7 à 10 alcoylphosphonothioates.

the oligonucleotide analog of claim 2 having from 2 to 60 akylphosphonates or alkylphosphonothioates.
analogue oligonucléotidique selon la revendication 2, comportant de 2 à 60 alcoylphosphonates ou alcoylphosphonothioates.

disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmacological formulation comprising a chimeric oligunucleotide complementary to the gene is orally administered to an animal. the oligonucleotide adminsitered has at least one phosphorothioate internucleotide linkage and at least one alkylphosphonate, phosphorodithioate, alkylphosphonothioate, phosphoramidate, phosphoramidite, phosphate ester, carbamate, carbonate, phosphate triester, acetamidate, or carboxymethyl ester internucleotide linkage.
l'invention concerne une méthode destinée à la régulation négative de l'expression d'un gène chez un animal. cette méthode consiste à administrer, par voie orale, une composition pharmaceutique renfermant un oligonucléotide chimérique complémentaire de ce gène à un animal. l'oligonucléotide administré comprend au moins une liaison internucléotidique phosphorothioate et au moins une liaison internucléotidique alkylphosphonate, phosphorodithioate, alkylphosphonothioate, phosphoramidate, phosphoramidite, ester phosphorique, carbamate, carbonate, triester phosphorique, acétamidate ou ester carboxyméthylique.