Você procurou por: asparagine (Inglês - Maltês)

complete asparagine depletion in csf
tnaqqis komplet ta’ asparagine f’csf

complete asparagine depletion in serum
tnaqqis komplet ta’ asparagine fis-serum

asparaginase hydrolyses asparagine to aspartic acid and ammonia.
asparaginase jidrolizza asparagine għal aspartic acid u ammonia.

all cells need an amino acid called asparagine to stay alive.
iċ-ċelluli kollha għandhom bżonn ta’ amino acid imsejjaħ asparagine biex jibqgħu ħajjin.

therefore, they require asparagine which diffuses from the extracellular environment.
għalhekk, huma jeħtieġu asparagine li jinfirex mill-ambjent extraċellulari.

csf asparagine concentrations were determined in 50 patients during the induction phase.
il-konċentrazzjonijiet ta' csf asparagine ġew stabbilliti f'50 pazjent matul il-fażi ta' induzzjoni.

serum asparagine concentrations during the induction phase are shown in figure 1.
il-konċentrazzjonijiet ta' asparagine fis-serum matul il-fażi ta' induzzjoni qed jintwerew f'figura 1.

asparagine depletion in serum was complete in 11 of 12 patients (92%).
it-tnaqqis ta’ asparagine fis-serum kien komplet ħlief fi 11 minn 12-il pazjent (92%).

asparaginase lowers asparagine level in blood cancer cells and stops the cancer growing.
asparaginase ibaxxi l-livell ta’ asparagine fiċ-ċelluli tal-kanċer tad-demm u jwaqqaf it- tkabbir tal-kanċer.

oncaspar lowers asparagine level in blood cancer cells and stops the cancer cells growing.
oncaspar ibaxxi l-livell ta' asparagine fiċ-ċelluli tal-kanċer tad-demm u jwaqqaf iċ-ċelluli tal-kanċer milli jikbru.

csf asparagine decreased from a mean pre-treatment concentration of 3.1 µm to 1.7 µm on
csf asparagine naqas minn konċentrazzjoni medja qabel il-kura ta' 3.1 µm għal 1.7 µm f'jum 4  1 u

normal cells, by contrast, can produce their own asparagine and are less affected by the medicine.
iċ-ċelloli normali, għall-kuntrarju, jistgħu jipproduċu l-asparagine tagħhom stess u huma inqas affettwati mill- mediċina.

asparaginase may also be toxic to normal cells that divide rapidly and are dependent to some degree on exogenous asparagine supply.
asparaginase jista’ wkoll ikun tossiku għal ċelluli normali, li jiddividu b’mod mgħaġġel u li huma dipendenti sa ċertu grad fuq il-provvista esoġena ta’ asparagine.

anti-leukaemic effect of l-asparaginase is related to a sustained l-asparagine depletion.
effett antilewkimiku ta' l-asparaginase hu relatat ma’ tnaqqis sostnut ta’ l-asparagine.

the patterns of serum asparagine depletion in the 2 delayed intensification phases are similar to the pattern of serum asparagine depletion in the induction phase.
l-andament tat-tnaqqis ta' asparagine fis-serum fiż-2 fażijiet ta' intensifikazzjoni mdewma huma simili għall-andament ta' tnaqqis ta' asparagine fis-serum fil-fażi ta' induzzjoni.

in insulin glulisine the replacement of the human insulin amino acid asparagine in position b3 by lysine and the lysine in position b29 by glutamic acid favors more rapid absorption.
fl-insulina glulisine, is-sostituzzjoni ta’ l-aċidu amminiku asparagine ta’ l-insulina umana f’pożizzjoni b3 b’lysine, u l-lysine f’pożizzjoni b29 sostitut bl-aċidu glutamiku, jiffavorixxu l-assorbiment aktar mgħaġġel.

in contrast to normal cells, lymphoblastic tumour cells have a very limited capacity for synthesising asparagine because of a significantly reduced expression of asparagine synthetase.
b’kuntrast ma’ ċelluli normali, iċ- ċelluli limfoblastiċi tat-tumur għandhom kapaċità limitata ħafna biex jissintetizzaw lil asparagine minħabba espressjoni mnaqqsa b’mod sinifikanti ta’ asparagine synthetase.

as a result of asparaginase-induced asparagine depletion in serum, protein synthesis in lymphoblastic tumour cells is disturbed while sparing most normal cells.
b’riżultat ta’ tnaqqis ta’ asparagine fis-serum indott minn asparaginase, is-sintesi tal-proteini f’ċelluli limfoblastiċi tat-tumur tiġi mfixkla, filwaqt li fil- parti l-kbira ta’ ċelluli normali dan ma jseħħx.

even those few patients with trough asparaginase serum activity levels of 10 – 100 u/l usually experienced complete asparagine depletion in serum and csf.
anki dawk ftit pazjenti b’livelli minimi ta’ attività ta’ asparaginase fis-serum ta’ asparaginase ta’ 10 – 100 u/l, normalment kellhom tnaqqis komplet ta’ asparagine fis-serum u fis-csf.

normal cells, in contrast, are capable of synthesising l-asparagine and are less affected by its rapid withdrawal during treatment with the enzyme l-asparaginase.
b'kuntrast ma' dan, iċ-ċelluli normali huma kapaċi jissintetizzaw l-asparagine u jiġu affettwati inqas mill-irtirar mgħaġġel tiegħu matul il-kura bl-enzima l-asparaginase.