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metabolism-medierad toxicitet
metabolism-mediated toxicity

antikropps-medierad erytroblastopeni (prca)
antibody-mediated erythroblastopenia (prca)

linagliptin hämmar således inte oct-medierad transport.
therefore, linagliptin is not an inhibitor of oct-mediated transport.

in vivo genom hämning av cyp- medierad metabolism. me
thus, fondaparinux is not expected to interact with other medicinal products in vivo by inhibition of cyp-mediated metabolism. ed

40 ritonavir inhibierar cyp3a- medierad metabolism av ketokonazol.
200 daily 500 q12h ↑ 3.4-fold ↑ 55% ritonavir inhibits cyp3a-mediated metabolism of ketoconazole.

det beror troligen på induktion av cyp1a2- medierad metabolism.
clearance of cinacalcet is higher in smokers than in non-smokers, likely due to induction of cyp1a2- mediated metabolism.

grapefruktjuice påverkar cyp3a4 medierad metabolism och skall därför undvikas.
grapefruit juice affects cyp3a4 mediated metabolism and should therefore be avoided.

zonisamid har också en begränsande effekt på gaba-medierad neuroninhibitering.
zonisamide also has a modulatory effect on gaba-mediated neuronal inhibition.

i njurarna sker även tubulär resorption, troligen medierad av katjonaktiva transportproteiner.
renal handling also involves tubular reabsorption, probably mediated by cation transport proteins.

manliga patienter skall uppmärksammas på risken för manligt medierad fetal toxicitet.
male patients should be aware of the possible male-mediated foetal toxicity.

dynastat påverkade inte den acetylsalicylsyra-medierad hämningen av trombocytaggregation eller blödningstider.
dynastat had no effect on acetylsalicylic acid-mediated inhibition of platelet aggregation or bleeding times.

metabolismen sker primärt via kolinesteras-medierad hydrolys till metaboliten nap226-90.
metabolism is primarily via cholinesterase-mediated hydrolysis to the metabolite nap226-90.

flutikasonfuroat elimineras snabbt genom höggradig förstapassage-metabolism medierad av cytokrom p450 3a4.
fluticasone furoate is rapidly cleared by extensive first pass metabolism mediated by the cytochrome p450 3a4.

doripenem genomgår liten till ingen cytokrom p450-medierad (cyp450) metabolism.
doripenem undergoes little to no cytochrome p450 (cyp450) mediated metabolism.

boceprevir genomgår också, i mindre utsträckning, oxidativ metabolism medierad via cyp3a4/5.
boceprevir also undergoes, to a lesser extent, oxidative metabolism mediated by cyp3a4/5.

metabolismen av dapagliflozin sker primärt via glukuronidkonjugering medierad av udp- glukuronosyltransferas 1a9 (ugt1a9).
the metabolism of dapagliflozin is primarily via glucuronide conjugation mediated by udp-glucuronosyltransferase 1a9 (ugt1a9).

bazedoxifen genomgår lite eller ingen cytokrom p450-medierad (cyp-medierad) metabolism.
bazedoxifene undergoes little or no cytochrome p450 (cyp)-mediated metabolism.

eftersom mabcampath är ett rekombinant humaniserat protein förväntas inte någon p450-medierad interaktion läkemedel-läkemedel.
because mabcampath is a recombinant humanized protein, a p450 mediated drug-drug interaction would not be expected.

firocoxib verkar genom selektiv hämning av cyklooxygenas- 2 (cox- 2) - medierad prostaglandinsyntes.
firocoxib is a non-steroidal anti-inflammatory drug (nsaid) belonging to the coxib group, which acts by selective inhibition of cyclooxygenase-2 (cox-2)-mediated prostaglandin synthesis.

cmin: ↑ 25 % (↑ 7 till ↑ 46) (hämning av cyp-medierad oxidativ metabolism)
cmin: ↑ 25% (↑ 7 to ↑ 46) (inhibition of cyp-mediated oxidative metabolism)