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the cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
the cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
(1983) components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown.
(1983) components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown.
processing beings when dna-pk binds to each broken dna end and recruits several other proteins including artemis, xrcc4, dna ligase iv, cernunnos, and several dna polymerases.
dna-pk binds to each end of the broken dna and recruits several other proteins, including artemis nuclease, xrcc4 (x-ray repair cross-complementing factor 4), dna ligase iv, cernunnos (also called xlf or xrcc4-like factor), and any of several dna polymerases.
==genes==the following are some of the genes located on chromosome 15:* capn3: calpain 3 (limb-girdle muscular dystrophy type 2a)* chp: calcium binding protein p22* fah: fumarylacetoacetate hydrolase (fumarylacetoacetase)* fbn1: fibrillin 1 (marfan syndrome)* hexa: hexosaminidase a (alpha polypeptide)(tay-sachs disease)* ivd: isovaleryl coenzyme a dehydrogenase* mcph4: microcephaly, primary autosomal recessive 4* oca2: oculocutaneous albinism ii (pink-eye dilution homolog, mouse)* rad51: rad51 homolog (reca homolog, e. coli) (s. cerevisiae)* strc: stereocilin* ube3a: ubiquitin protein ligase e3a (human papilloma virus e6-associated protein, angelman syndrome)* pml: promyelocytic leukemia protein (involved in t(15,17) with raralpha, predominant cause of acute promyelocytic leukemia.
== genler ==kromozom 15 üzerinde bulunan genlerden bazıları:* fah: fumarilasetoasetat hidrolaz(fumarilasetoasetaz)* fbn1: fibrillin 1 (marfan sendromu)* hexa: hegzozaminidaz a (alfa polipeptid)* ivd: izovaleril koenzim a dehidrojenaz* oca2: okülokutanöz albinizm ii (pembe-göz dilution homoloğu, fare)* rad51: rad51 homoloğu (reca homoloğu, "e. coli") ("s. cerevisiae")* strc: stereosilin* ube3a: ubikuitin protein ligaz e3a (insan papilloma virüs e6-ilişkili protein, angelman sendromu)* pml: promiyelositik lösemi proteini ( raralpha ile birlikte t(15,17)'u içerir, akut promiyelositik löseminin önde gelen nedeni.