Вы искали: presystemic (Английский - Хорватский)

presystemic glucuronidation is extensive.
predsistemska glukuronidacija je opsežna.

presystemic glucuronidation is exten sive.
predsistemska glukuronidacija je opsežna.

zaleplon is metabolised primarily by the liver and undergoes significant presystemic metabolism.
zaleplon se primarno metabolizira putem jetre i podliježe značajnom predsistemskom metabolizmu.

sodium oxybate undergoes significant presystemic (hepatic first-pass) metabolism.
natrijev oksibat prolazi značajan presistemski metabolizam (prvi prolaz kroz jetru).

given the in vitro inhibition data, presystemic inhibition of cyp3a4 by idebenone cannot be excluded.
uzimajući u obzir podatke o in vitro inhibiciji ne može se isključiti presistemska inhibicija cyp3a4 uzrokovana idebenonom.

following oral administration, mycophenolate mofetil undergoes rapid and extensive absorption and complete presystemic metabolism to the active metabolite, mpa.
nakon peroralne primjene, mofetilmikofenolat brzo se i ekstenzivno apsorbira i prolazi cjelokupni metabolizam sve do aktivnog metabolita, mpa.

these differences were likely to be caused by lower presystemic metabolism of anagrelide to 3-hydroxy anagrelide in the elderly patients.
te su razlike vjerojatno posljedica slabijeg predsistemskog metabolizma anagrelida u 3-hidroksianagrelid u starijih bolesnika.

however due to presystemic first pass metabolism, the absolute bioavailability of dronedarone (given with food) is 15%.
međutim, zbog predsistemskog metabolizma prvog prolaza, ukupna bioraspoloživost dronedarona (primijenjena uz hranu) iznosi 15%.

the remainder of the inhaled dose of fluticasone propionate may be swallowed but contributes minimally to systemic exposure due to the low aqueous solubility and presystemic metabolism, resulting in oral availability of less than 1%.
preostala udahnuta doza flutikazonpropionata može biti progutana, no minimalno pridonosi sistemskoj izloženosti zbog male topljivosti u vodi i presistemskog metabolizma, što rezultira peroralnom raspoloživošću manjom od 1%.

orally administered tecfidera (dimethyl fumarate) undergoes rapid presystemic hydrolysis by esterases and is converted to its primary metabolite, monomethyl fumarate, which is also active.
peroralno primijenjena tecfidera (dimetilfumarat) prolazi brzu presistemsku hidrolizu pomoću esteraza i pretvara se u svoj primarni metabolit, monometilfumarat, koji je također aktivan.

less nap226-90 is formed following application of the transdermal patch, presumably because of the lack of presystemic (hepatic first pass) metabolism, in contrast to oral administration.
nakon primjene transdermalnog flastera stvara se manje nap226-90, vjerojatno zbog nedostatka presistemskog metabolizma (prvi prolaz kroz jetru), za razliku od oralne primjene.