Вы искали: disregulazzjoni (Мальтийский - Английский)

pazjenti b’mf juru sinjali ta’ disregulazzjoni ta’ jak indipendentament mill-istat ta’ mutazzjoni ta’ jak2v617f.
mf patients exhibit dysregulated jak signalling regardless of jak2v617f mutation status.

il-mjelofibrożi u l-poliċitemija vera huma neoplażmi mjeloproliferattivi magħrufa li huma assoċjati ma’ disregulazzjoni tas-sinjali ta’ jak1 u jak2.
myelofibrosis and polycythaemia vera are myeloproliferative neoplasms known to be associated with dysregulated jak1 and jak2 signalling.

hu maħsub li l-bażi għal din id-disregulazzjoni tinkludi livelli għolja ta’ ċitokini ċirkulatorji li jattivaw il-mogħdija ta’ jak-stat, il-mutazzjonijiet tal-kisba tal-funzjoni bħalma huma jak2v617f, u t-trażżin ta’ mekkaniżmi regulatorji negattivi.
the basis for the dysregulation is believed to include high levels of circulating cytokines that activate the jak-stat pathway, gain-of-function mutations such as jak2v617f, and silencing of negative regulatory mechanisms.