You searched for: upregulation (Engelska - Italienska)

upregulation
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downregulation and upregulation
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in human cancer xenograft models capecitabine demonstrated a synergistic effect in combination with docetaxel, which may be related to the upregulation of thymidine phosphorylase by docetaxel.
nei modelli tumorali da xenotrapianto umano la capecitabina ha dimostrato di avere un effetto sinergico in associazione a docetaxel, che può essere correlato alla iperegolazione della timidina fosforilasi da parte di docetaxel.

findings of a study in mice suggest that in morphine dependence, upregulation of cannabinoid cb1 receptors occurs. thus, cb1 receptor agonists may have potential as therapeutic drugs for opiate withdrawal symptoms.
delle scoperte di uno studio sui topi suggeriscono che nella dipendenza da morfina, si verifica un aumento della attività dei ricettori cannabinoidi cb1. in tal modo, gli agonisti dei ricettore cb1 possono avere un potenziale come farmaci terapeutici per i sintomi di astinenza da oppiacei.

laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and obesity. the relationship between sleep restriction, weight gain and diabetes risk may involve alterations in glucose metabolism, upregulation of appetite, and decreased energy expenditure.1
studi epidemiologici e di laboratorio suggeriscono che la perdita di ore di sonno può giocare un ruolo nell’aumento della prevalenza del diabete e dell’obesità. la relazione tra diminuzione delle ore di sonno, aumento di peso e rischio di diabete interessa le alterazioni nel metabolismo del glucosio, l’aumento dell’appetito e la diminuzione del consumo energetico.

alzheimer’s disease (ad), the most common neurodegenerative disorder, is the leading cause of dementia. neuritic plaque, one of the major characteristics of ad neuropathology, mainly consists of amyloid β (aβ) protein. aβ is derived from amyloid precursor protein (app) by sequential cleavages of β- and γ-secretase. although app upregulation can promote ad pathogenesis by facilitating aβ production, growing evidence indicates that aberrant post-translational modifications and trafficking of app play a pivotal role in ad pathogenesis by dysregulating app processing and aβ generation. in this report, we reviewed the current knowledge of app modifications and trafficking as well as their role in app processing. more importantly, we discussed the effect of aberrant app modifications and trafficking on aβ generation and the underlying mechanisms, which may provide novel strategies for drug development in ad
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