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die biotransformationswege und die metaboliten sind noch nicht vollständig aufgeklärt.
the biotransformation pathways as well as the metabolites are not fully characterised.
Son Güncelleme: 2017-04-26
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sekundäre biotransformationswege unter beteiligung von produkten der primären biotransformation waren die glukuronidierung und die dehydrierung.
secondary biotransformation pathways involving the primary biotransformation products included glucuronidation and dehydrogenation.
Son Güncelleme: 2017-04-26
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aripiprazol wird überwiegend in der leber hauptsächlich über drei biotransformationswege metabolisiert: dehydrierung, hydroxylierung und n-dealkylierung.
aripiprazole is extensively metabolised by the liver primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and n-dealkylation.
Son Güncelleme: 2017-04-26
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der metabolismus von fulvestrant ist nicht vollständig geklärt, beinhaltet aber kombinationen einer anzahl verschiedener biotransformationswege, die denen von endogenen steroiden entsprechen.
metabolism the metabolism of fulvestrant has not been fully evaluated, but involves combinations of a number of possible biotransformation pathways analogous to those of endogenous steroids.
Son Güncelleme: 2011-10-23
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Uyarı: Bu hizalama yanlış olabilir..
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die wichtigsten identifizierten biotransformationswege sind oxidierung und abbau der imidazol- und piperazinringe, oxidative o-dealkylierung und aromatische hydroxylierung.
the major identified metabolic pathways are oxidation and degradation of the imidazole and piperazine rings, oxidative o-dealkylation and aromatic hydroxylation.
Son Güncelleme: 2017-04-26
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studien an menschlichen leberpräparaten und rekombinanten menschlichen enzymen zeigen, dass cyp 3a4 das einzige p-450 isoenzym ist, das an der oxidation von fulvestrant beteiligt ist, jedoch scheinen in vivo nicht durch p450 vermittelte biotransformationswege zu überwiegen.
studies using human liver preparations and recombinant human enzymes indicate that cyp 3a4 is the only p450 isoenzyme involved in the oxidation of fulvestrant, however non-p450 routes appear to be more predominant in vivo.
Son Güncelleme: 2012-04-10
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Uyarı: Bu hizalama yanlış olabilir..
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cabazitaxel bewirkte in vitro keine hemmung des hauptsächlichen biotransformationswegs von warfarin in 7-hydroxywarfarin, der über cyp2c9 vermittelt wird.
cabazitaxel did not inhibit in vitro the major biotransformation pathway of warfarin into 7-hydroxywarfarin, which is mediated by cyp2c9.
Son Güncelleme: 2017-04-26
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