Şunu aradınız:: glukuronidacija (Slovence - İngilizce)

predsistemska glukuronidacija je obsežna.
presystemic glucuronidation is exten sive.

glavna presnovna pot je glukuronidacija.
glucuronidation is the major metabolic pathway.

glavna pot ii. faze presnove je glukuronidacija fenolne skupine.
phenolic glucuronidation is the major phase ii metabolic route.

glukuronidacija deferasiroksa poteka predvsem z ugt1a1, manj pa z ugt1a3.
deferasirox is mainly glucuronidated by ugt1a1 and to a lesser extent ugt1a3.

glukuronidacija in izločanje nespremenjenega tigeciklina skozi ledvice sta manj pomembni poti.
glucuronidation and renal excretion of unchanged tigecycline are secondary routes.

perampanel se obširno presnavlja s primarno oksidacijo, ki ji sledi glukuronidacija.
perampanel is extensively metabolised via primary oxidation and sequential glucuronidation.

glavna metabolična pot deferasiroksa je glukuronidacija, ki ji sledi izločanje z žolčem.
glucuronidation is the main metabolic pathway for deferasirox, with subsequent biliary excretion.

glavna presnovna pot eslikarbazepina in lamotrigina je glukuronidacija, zato bi lahko pričakovali interakcije.
glucuronidation is the major metabolic pathway for both eslicarbazepine and lamotrigine and therefore an interaction could be expected.

med sekundarnimi potmi biotransformacije, ki vključujejo produkte primarne biotransformacije, sta glukuronidacija in dehidrogenacija.
secondary biotransformation pathways involving the primary biotransformation products included glucuronidation and dehydrogenation.

ti podatki kažejo, da glukuronidacija z ugt1a1 pri človeku predstavlja glavni mehanizem očistka raltegravirja.
thus the data indicate that the major mechanism of clearance of raltegravir in humans is ugt1a1-mediated glucuronidation.

na osnovi podatkov študije z radioaktivnim izotopom označenega eltrombopaga pri ljudeh je glukuronidacija manj pomembna za presnovo eltrombopaga.
based on a human study with radiolabelled eltrombopag, glucuronidation plays a minor role in the metabolism of eltrombopag.

glavni presnovni proces je demetilacija in glukuronidacija, vendar encimov, ki sodelujejo pri presnovi, še niso natančno določili.
the main metabolic processes are demethylenation and glucuronidation, although precise identification of the enzymes involved has not yet been achieved.

v vzorcih človeškega blata niso odkrili sulfatnih ali glukuronidnih konjugatov, kar kaže na to, da sulfatacija in glukuronidacija nista pomembni poti, vpleteni v izločanje temsirolimusa.
sulfate or glucuronide conjugates were not detected in the human faecal samples, suggesting that sulfation and glucuronidation do not appear to be major pathways involved in the excretion of temsirolimus.

4 etravirin se presnovi s cyp3a4, cyp2c9 in cyp2c19, temu pa sledi glukuronidacija z uridin difosfat glukuronozil transferazo (udpgt).
medicinal products that affect etravirine exposure etravirine is metabolised by cyp3a4, cyp2c9 and cyp2c19 followed by glucuronidation by uridine diphosphate glucuronosyl transferase (udpgt).

etravirin se presnavlja z encimi cyp3a4, cyp2c9 in cyp2c19, temu sledi glukuronidacija nastalih presnovkov z uridin difosfat glukuronozil transferazo (udpgt).
etravirine is metabolised by cyp3a4, cyp2c9 and cyp2c19 followed by glucuronidation of the metabolites by uridine diphosphate glucuronosyl transferase (udpgt).

o-glukuronidacija je glavna presnovna pot izločanja kanagliflozina, in sicer večinoma poteka z encimoma ugt1a9 in ugt2b4, pri čemer nastaneta dva neaktivna o-glukuronidna presnovka.
o-glucuronidation is the major metabolic elimination pathway for canagliflozin, which is mainly glucuronidated by ugt1a9 and ugt2b4 to two inactive o-glucuronide metabolites.

biotransformacija odkritih je bilo sedem glavnih presnovkov in poti presnove kot so: glukuronidacija na piridinskem dušiku, oksidacija piridinskega dušika s hidroksilacijo na mestu 3´ indanskega obroča ali brez nje, hidroksilacija indana na mestu 3´, hidroksilacija fenilmetilne skupine na mestu para in demetilacija piridinskega dušika s hidroksilacijo na mestu 3´ ali brez nje.
biotransformation seven major metabolites were identified and the metabolic pathways were identified as glucuronidation at the pyridine nitrogen, pyridine– n– oxidation with and without 3’– hydroxylation on the indane ring, 3’– hydroxylation of indane, p– hydroxylation of phenylmethyl moiety, and n– depyridomethylation with and without the 3’– hydroxylation.