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teratogenost
teratogenicity
Son Güncelleme: 2017-04-26
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tveganje za teratogenost
teratogenic risk
Son Güncelleme: 2017-04-26
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poslabšanje plodnosti in teratogenost
impairment of fertility and teratogenicity
Son Güncelleme: 2017-04-26
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teratogenost bortezomiba še ni bila v celoti raziskana.
the teratogenic potential of bortezomib has not been fully investigated.
Son Güncelleme: 2017-04-26
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niso pa našli dokazov za teratogenost in vpliv na plodnost.
data from reproductive toxicology tests in rats and rabbits at doses near the maximum tolerated dose and/or maternally toxic doses showed reproductive (embryotoxicity in rats, embryo resorption and foetotoxicity in rabbits) and developmental (decrease in pup growth and survival in rats) toxicity, but was not teratogenic and did not impair fertility.
Son Güncelleme: 2011-10-23
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tveganje za teratogenost in pomembni ukrepi za zmanjšanje tveganja:
the risk of teratogenicity and relevant risk minimisation advice:
Son Güncelleme: 2017-04-26
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artenimol povzroča smrtnost zarodkov in teratogenost pri podganah in kuncih.
artenimol causes embryolethality and teratogenicity in rats and rabbits.
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ženske v rodni dobi je treba seznaniti s tveganjem za teratogenost;
women of childbearing potential should be informed about the risk of teratogenicity;
Son Güncelleme: 2017-04-26
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ta študija se zahteva, če teratogenost ni bila preučena v študiji plodnosti.
this study is required if teratogenicity has not been examined in the fertility study.
Son Güncelleme: 2014-10-18
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višji odmerki so povzročili maternalno in fetusno toksičnost brez dokazov za teratogenost.
higher doses resulted in maternal and foetal toxicity without evidence of teratogenicity.
Son Güncelleme: 2017-04-26
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2bpodatki o vplivu na sposobnost razmnoževanja kažejo teratogenost asa pri več laboratorijskih živalih.
reproduction toxicity data show that asa is teratogenic in several laboratory animals.
Son Güncelleme: 2017-04-26
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obstaja možno tveganje za teratogenost, zato je zdravilo vibativ v času nosečnosti kontraindicirano.
that there is a potential risk of teratogenicity and vibativ is contraindicated during pregnancy.
Son Güncelleme: 2017-04-26
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ta študija je potrebna, če teratogenost ni bila preiskana ali ocenjena v predhodni študiji plodnosti.
this study is required if teratogenicity has not been examined or evaluated in the preceding fertility study.
Son Güncelleme: 2014-11-21
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ni dokazov, da bi sistemska izpostavljenost rhuph20 povzročila dismorfogenezo (tj. teratogenost).
there is no evidence of dysmorphogenesis (i.e. teratogenesis) resulting from systemic exposure to rhuph20.
Son Güncelleme: 2017-04-26
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v študijah o embriotoksičnosti in teratogenosti pri miših so opazili od odmerka odvisno povečanje odmrtja ploda in teratogenost.
in embryotoxicity and teratogenicity studies in mice, dose-related increases in foetal resorption and teratogenicity were observed.
Son Güncelleme: 2017-04-26
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za sorodno spojino razoksan so ugotovili embriotoksičnost pri miših, podganah in kuncih ter teratogenost pri podganah in miših.
the related razoxane has been demonstrated to be embryotoxic in mice, rats and rabbits and teratogenic in rats and mice.
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Če je plazemska koncentracija v obeh primerih manjša od 0,02 mg/l, ni pričakovati tveganja za teratogenost.
if both plasma concentrations are below 0.02 mg/l no teratogenic risk is to be expected.
Son Güncelleme: 2017-04-26
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v celoti ti podatki ne kažejo bistvenega povečanja tveganja za hujše prirojene malformacije, čeprav tveganja za teratogenost ni mogoče povsem izključiti.
overall, these data do not suggest a substantial increase in the risk for major congenital malformations, although a teratogenic risk cannot be completely excluded.
Son Güncelleme: 2017-04-26
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kot večina retinoidov je tudi beksaroten v poskusih na živalih pokazal teratogenost in embriotoksičnost pri sistemskih izpostavljenostih, ki se lahko klinično dosežejo tudi pri ljudeh.
bexarotene, in common with the majority of retinoids, was teratogenic and embryotoxic in an animal test species at systemic exposures that are achievable clinically in humans.
Son Güncelleme: 2017-04-26
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teratogenost v študiji s peroralnimi odmerki pri kuncih je alitretinoin induciral hude malformacije pri 35- krat večjem odmerku v primerjavi z lokalnim odmerkom pri ljudeh.
teratogenicity in an oral dose-ranging study in rabbits, alitretinoin induced gross malformations at a dose 35 times the topical human dose.
Son Güncelleme: 2011-10-23
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