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genotoxicity (mutagenity, klastogenicity);
genotoxicity (mutagenicity, clastogenicity);
Son Güncelleme: 2014-11-21
Kullanım Sıklığı: 1
Kalite:
musí být předloženy výsledky zkoušek mutagenity in vitro (zkouška genových mutací na bakteriích, zkouška klastogenicity na buňkách savců a zkouška genových mutací na buňkách savců).
results of in vitro mutagenicity tests (bacterial assay for gene mutation, test for clastogenicity in mammalian cells and test for gene mutation in mammalian cells) must be provided.
vedlejší metabolit tfma (4-trifluorometylanilin) sice způsoboval in vitro klastogenicitu a bodovou mutaci, ale o jeho potenciálu vyvolávat tento účinek in vivo nejsou dostatečné informace.
however, the minor metabolite tfma (4-trifluoromethylaniline) caused clastogenicity and point mutations in vitro, whilst insufficient information was available on its potential to exert this effect in vivo.