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[0104] resistance to renewal proteases and a decrease in fibrillogenesis and hence in the renewal of collagen, a reduction in its filter effect in the extracellular matrix and more particularly at the dermis/epidermis boundary after fixing of foreign proteins (ldl, cholesterol, albumin) which leads to thickening, [0105] the glycosylated proteins represent a potential source of free oxygen radicals. this phenomenon—intensified by uv-a—leads to collagen degradation, [0106] activation of non-specific harmful proteases, [0107] activation of macrophages and dumping of cytokinins (tnf-alpha) [0108] finally inflammation with subsequent fibrosis and deposition of lipofuszin. [0109] the foregoing observations are of interest for the use of substances with anti-glycosylation activity, more particularly in the control and prevention of ageing of the skin and especially the hair in the cosmetics field.
diese eliminierung läßt jedoch mit zunehmendem alter nach, was eine anreicherung dieser glykosylierten proteine und eine beschleunigte und verstärkte alterung der dermis zur folge hat, wofür die summe mehrerer phänomene verantwortlich ist: die obigen ausführungen sind für die verwendung von substanzen mit anti-glykosylierungs-aktivität, insbesondere bei der bekämpfung und prävention der haut- und insbesondere der haaralterung in der kosmetik, von interesse.