Şunu aradınız:: hydroxylation (İngilizce - Slovakça)

hydroxylation
hydroxylácia

further hydroxylation occurs prior to elimination.
Ďalšia hydroxylácia nastáva pred elimináciou.

n-dealkylation and/ or hydroxylation to yield:
n- dealkyláciou a/ alebo hydroxyláciou so vznikom:

biotransformations in the cat occur by hydroxylation in the liver.
u mačiek dochádza k biotransformáciám hydroxyláciou v pečeni.

doxazosin is primarily metabolised by o-demethylation and hydroxylation.
doxazosín sa metabolizuje najmä o- demetyláciou a hydroxyláciou.

sirolimus is extensively metabolised by o-demethylation and/or hydroxylation.
sirolimus je výraznou mierou metabolizovaný o-demetyláciou a/alebo hydroxyláciou.

celecoxib is metabolised in the liver by hydroxylation, oxidation and some glucuronidation.
celekoxib sa metabolizuje v peceni hydroxyláciou, oxidáciou a do istej miery glukuronidáciou.

cyp3a4 is concluded to be the predominant isoenzyme responsible for hydroxylation of indacaterol.
usudzuje sa, že cyp3a4 je hlavným izoenzýmom zodpovedným za hydroxyláciu indakaterolu.

the predominant metabolic pathways of excreted radioactivity are hydroxylation with subsequent glucuronidation, or hydrolysis.
hlavnými metabolickými dráhami eliminácie rádioaktivity sú hydroxylácia s následnou glukuronidáciou alebo hydrolýzou.

the major metabolic pathway is deboronation to form two deboronated metabolites that subsequently undergo hydroxylation to several metabolites.
hlavnou metabolickou cestou je deboronácia na dva deboronované metabolity, ktoré sa nasledovne štiepia hydroxyláciou na niekoľko metabolitov.

major biotransformations in the dog include hydroxylation, glucuronic acid conjugation and n- methylation in the liver.
u psov patrí medzi hlavné biotransformácie hydroxylácia, konjugácia kyseliny glukoronovej a n- metylácia v pečeni.

the major routes of metabolism are n-demethylation and hydroxylation, followed by conjugation with sulphate and glucuronic acid.
hlavnými cestami metabolizmu sú n-demetylácia a hydroxylácia, následne konjugácia so sulfátom a kyselinou glukurónovou.

even though micafungin is a substrate for cyp3a in vitro, hydroxylation by cyp3a is not a major pathway for micafungin metabolism in vivo.
hoci je mikafungín in vitro substrátom pre cyp3a, hydroxylácia prostredníctvom cyp3a nie je hlavnou metabolickou cestou pre mikafungín in vivo.

the initial products of the hydroxylation and n-dealkylation pathways are major circulating metabolites but none contribute significantly to the overall clinical effect of darifenacin.
prvé produkty hydroxylačnej a n-dealkylačnej dráhy sú hlavné cirkulujúce metabolity, ale žiaden z nich neprispieva významne k celkovému klinickému účinku darifenacínu.

aripiprazole is extensively metabolised by the liver primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and n-dealkylation.
aripiprazol sa v rozsiahlej miere metabolizuje v pečeni hlavne tromi biotransformačnými cestami: dehydrogenáciou, hydroxyláciou a n-dealkyláciou.

based on in vitro studies, cyp3a4 and cyp2d6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and n-dealkylation is catalysed by cyp3a4.
na základe in vitro štúdií sú enzýmy cyp3a4 a cyp2d6 zodpovedné za dehydrogenáciu a hydroxylácia aripiprazolu a n-dealkylácia je katalyzovaná enzýmom cyp3a4.

aromatic and aliphatic hydroxylation or glucuronidation metabolites are present in very low levels, display considerably lower anti-hiv activity and do not contribute to the overall antiviral activity of elvitegravir.
metabolity aromatickej a alifatickej hydroxylácie alebo glukuronidácie sú prítomné vo veľmi nízkych koncentráciách, vykazujú značne nižšiu aktivitu proti hiv a neprispievajú k celkovej antivírusovej aktivite elvitegraviru.

in vitro studies using human liver microsomes indicate that cyp1a1 is the major enzyme responsible for the 7-hydroxylation of granisetron, whereas cyp3a4 contributes to 9’desmethylation.
in vitro štúdie použitím ľudských pečeňových mikrozómov naznačujú, že cyp1a1 je hlavný enzým zodpovedný za 7-hydroxyláciu granisetronu, zatiaľ čo cyp3a4 prispieva k 9´dezmetylácii.

in addition to the active metabolite, inactive metabolites are formed, including two major metabolites formed by hydroxylation of the butyl side chain and a minor metabolite, an n-2 tetrazole glucuronide.
okrem aktívneho metabolitu sa tvoria aj neaktívne metabolity vrátane dvoch hlavných metabolitov vytvorených hydroxyláciou butylového postranného reťazca a menej významného metabolitu, n- 2 tetrazolglukuronidu.

four metabolic pathways have been identified in vivo, none of which accounted for more than 6.5% of the dose: dealkylation, hydroxylation, dehydrogenation, and benzisoxazole scission.
in vivo boli identifikované 4 metabolické dráhy, pričom žiadna z nich nepredstavovala viac ako 6,5 % z podanej dávky: dealkylácia, hydroxylácia, dehydrogenácia a benzisoxazolové štiepenie.