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problem i hud och underhud akut försämring av aknen framträder då och då under den initiala behandlingen men avklingar under fortsatt behandling, vanligtvis inom 7 – 10 dagar.
skin and subcutaneous tissues disorders acute exacerbation of acne is occasionally seen during the initial period but this subsides with continued treatment, usually within 7 - 10 days, and usually does not require dose adjustment.