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stor tumorbyrde er defineret som at have mindst et af følgende kriterier:stor tumorbyrde ( 7 cm) , involvering af mindst tre nodale områder (hver 3 cm) , systemiske symptomer (vægttab 10%, feber 38°c i mere end 8 dage, eller natlige svedeture) , splenomegali til under navlen, obstruktion af større organ eller kompressionssyndrom, orbital eller epidural involvering, serøs ekssudation eller leukæmi.
high tumour burden is defined as having at least one of the following: bulky tumour mass ( 7 cm) , involvement of three or more nodal sites (each 3 cm) , systemic symptoms (weight loss 10%, fever 38°c for more than 8 days, or nocturnal sweats) , splenomegaly beyond the umbilicus, major organ obstruction or compression syndrome, orbital or epidural involvement, serous effusion, or leukaemia.