您搜索了: solubilities (意大利语 - 英语)

theoretical and experimental relationships between soil adsorption, octanol-water partition coefficients, water solubilities, bioconcentration factors, and the parachor.
theoretical and experimental relationships between soil adsorption, octanol-water partition coefficients, water solubilities, bioconcentration factors, and the parachor.

high-throughput screening (hts) previously identified benzimidazole 1 (jmn3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. in pursuit of a lead compound from this series for development, we sought to increase both the potency and the aqueous solubility of 1. lead optimization has achieved compounds with potent antiviral activity against a panel of myxovirus family members (ec50 values in the low nanomolar range) and much improved aqueous solubilities relative to that of 1. additionally, we have devised a robust synthetic strategy for preparing 1 and congeners in an enantio-enriched fashion, which has allowed us to demonstrate that the (s)-enantiomers are generally 7- to 110-fold more potent than the corresponding (r)-isomers.
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