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keaf yra baltymas, suzadinantis angiogenez, kraujagysli pralaidum ir uzdegim procesus, kurie skatina senatvins geltonosios dms degeneracijos progresavim.
vegf is a secreted protein that induces angiogenesis, vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascular (wet) form of amd.
最后更新: 2008-03-04
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eafr zymimais keliais reguliuojamas lsteli islikimas, lstels ciklo progresavimas, angiogenez, lsteli migracija ir lsteli invazija/metastazavimas.
egfr signalling pathways are involved in the control of cell survival, cell cycle progression, angiogenesis, cell migration and cellular invasion/metastasis.
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sunitinibo malatas slopina daugialypius tirozino kinazs receptorius (tkr) , nuo kuri priklauso auglio augimas, patologin angiogenez ir vzio metastazi progresavimas.
sunitinib malate inhibits multiple receptor tyrosine kinases (rtks) that are implicated in tumour growth, pathologic angiogenesis, and metastatic progression of cancer.
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konkreciai, lenalidomidas slopina tam tikr hemopoetini navikini lsteli proliferacij (skaitant dm plasmos naviko lsteles bei tas lsteles, kuri 5 chromosomoje yra delecijos) , skatina t lsteli ir nk (angl.natural killer) lsteli lstelin imunitet bei padidina nk ir t lsteli skaici, slopin angiogenez blokuodamas endotelio lsteli migravim ir adhezij ir mikrokraujagysli formavimsi, padidina cd34+ kamienini lsteli fetalinio hemoglobino gamyb, monocituose slopina prouzdegimini citokin gamyb, pavyzdziui, tnf -ir il-6.
specifically, lenalidomide inhibits proliferation of certain haematopoietic tumour cells (including mm plasma tumour cells and those with deletions of chromosome 5) , enhances t cell-and natural killer (nk) cell-mediated immunity and increases the number of nk t cells, inhibits angiogenesis by blocking the migration and adhesion of endothelial cells and the formation of microvessels, augments foetal haemoglobin production by cd34+ haematopoietic stem cells, and inhibits production of pro-inflammatory cytokines (e. g., tnf-and il-6) by monocytes.
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