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konkreciai, lenalidomidas slopina tam tikr hemopoetini navikini lsteli proliferacij (skaitant dm plasmos naviko lsteles bei tas lsteles, kuri 5 chromosomoje yra delecijos) , skatina t lsteli ir nk (angl.natural killer) lsteli lstelin imunitet bei padidina nk ir t lsteli skaici, slopin angiogenez blokuodamas endotelio lsteli migravim ir adhezij ir mikrokraujagysli formavimsi, padidina cd34+ kamienini lsteli fetalinio hemoglobino gamyb, monocituose slopina prouzdegimini citokin gamyb, pavyzdziui, tnf -ir il-6.
specifically, lenalidomide inhibits proliferation of certain haematopoietic tumour cells (including mm plasma tumour cells and those with deletions of chromosome 5) , enhances t cell-and natural killer (nk) cell-mediated immunity and increases the number of nk t cells, inhibits angiogenesis by blocking the migration and adhesion of endothelial cells and the formation of microvessels, augments foetal haemoglobin production by cd34+ haematopoietic stem cells, and inhibits production of pro-inflammatory cytokines (e. g., tnf-and il-6) by monocytes.
最后更新： 2008-03-04
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