您搜索了: desmethylclomipramine (英语 - 斯洛文尼亚语)

240 nmol/ l for clomipramine and 48 nmol/ l for desmethylclomipramine.
največja plazemska koncentracija (cmax) pri peroralnem odmerku 2 mg/ kg je znašala za klomipramin 240 nmol/ l, za desmetilklomipramin 48 nmol/ l.

the major route of biotransformation of clomipramine is demethylation to desmethylclomipramine.
največ klomipramina se z desmetilacijo metabolizira v desmetilklomipramin.

the active components in vivo are clomipramine and its major metabolite, desmethylclomipramine.
glavni učinkovini zdravila clomicalm sta klomipramin in njegov glavni metabolit desmetilklomipramin.

peak plasma levels of clomipramine and desmethylclomipramine are rapidly reached (approx.
zaradi primarnega metabolizma v jetrih je biovaliabilnost klomipramina in desmetilklomipramina 22- 26%.

at steady state, the ratio of plasma clomipramine to desmethylclomipramine concentrations is approximately 3:1.
pri ustaljenih vrednostih je bilo razmerje med plazemsko koncentracijo klomipraminoma in desmetilklomipramina 3:1.

in the body, clomipramine and its major metabolite, desmethylclomipramine prevent some neurotransmitters from being taken back up into nerve cells in the brain and spinal cord.
v telesu klomipramin in njegov največji metabolit, desmetilklomipramin, preprečujeta ponovno vračanje nekaterih nevrotransmiterjev v živčne celice v možganih in hrbtenjači.

the elimination t1/2 after intravenous administration of clomipramine hydrochloride in dogs was 6.4 hours for clomipramine and 3.6 hours for desmethylclomipramine.
razpolovni čas izločanja (t1/2) po intravenskem dajanju znaša pri psih 6.4 ure za klomipramin in 3.6 ure za desmetilklomipramin.

clomipramine prevents the re-uptake of serotonin (5-hydroxytryptamine) and desmethylclomipramine prevents the re-uptake of noradrenalin.
klomipramin preprečuje ponovno prisvajanje serotonina (5- hidroksitriptamina) in desmetilklomipramin preprečuje ponovno prisvajanje noradrenalina.

administration of clomicalm with food causes moderately higher plasma auc values for clomipramine (25%) and desmethylclomipramine (8%) as compared with administration to fasted dogs.
pri dajanju zdravila skupaj s hrano so se zvišale plazemske vrednosti klomipramina za 25 %, desmetilklomipramina pa za 8 % v primerjavi s psi, ki hrane niso dobili.

clomipramine is well absorbed (> 80%) from the gastrointestinal tract in dogs when administered orally but the systemic bioavailability for clomipramine and desmethylclomipramine is 22-26% due to extensive first pass metabolism by the liver.
klomipramin se po peroralnem dajanju iz prebavil dobro absorbira (> 80%).