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de antitumorwerking van topotecan betreft de remming van topoisomerase-i, een enzym dat zeer betrokken is bij dna-replicatie, omdat het de draaibelasting juist voor de bewegende replicatievork verlicht.
the anti-tumour activity of topotecan involves the inhibition of topoisomerase-i, an enzyme intimately involved in dna replication as it relieves the torsional strain introduced ahead of the moving replication fork.
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