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apa ini masih ada
这个还有吗
Última actualización: 2022-02-19
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saya tidak bisa tidur
do not you work today??
Última actualización: 2021-10-24
Frecuencia de uso: 1
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selama persediaan masih ada
applies multiply
Última actualización: 2019-04-18
Frecuencia de uso: 1
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
Última actualización: 2014-04-24
Frecuencia de uso: 1
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berlaku selama persediaan masih ada
while supplies last
Última actualización: 2019-04-12
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masih ada syarat yang harus dilengkapi
there are still obstacles
Última actualización: 2012-04-22
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aku benci ketika aku tidak bisa tidur
i hate insomnia
Última actualización: 2023-07-28
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apa kah ada teman kamu yang bisa di ajak sex von
mi have your girl friend's whatsapp number
Última actualización: 2021-09-18
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anton adalah teman saya
dia berasal dari surabaya
Última actualización: 2021-12-09
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kamu adalah teman terbaik saya
thank you for being in my life
Última actualización: 2019-12-30
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aku tak bisa tidur, seperti burung yang kesepian di atap rumah
i watch, and am as a sparrow alone upon the house top.
Última actualización: 2012-05-06
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apakah aku adalah teman mu?
Última actualización: 2023-09-06
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aku baru saja bangun tidur dan tidak bisa tidur lagi. terus aku ingat kamu
i just wake up and can't sleep again. keep i remember you
Última actualización: 2018-12-10
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tegar adalah teman sekelasku yang merupakan sebangku ku. kejadian
Última actualización: 2024-03-05
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yang membuat saya tertawa hari ini adalah teman teman saya yang selalu berbuat konyol
that makes me
Última actualización: 2024-03-27
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dia laki laki adalah teman baik saya yang bernama kelvin sejak kami keci kami selalu bermain bersama
he is a good friend of mine named kelvin
Última actualización: 2020-03-12
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liburan pertama saya pergi ke rumah ely untuk berbuka puasa bersama, dia adalah teman rumahku
my holiday from sunday 31 03 24 to sunday 21 04 24
Última actualización: 2024-04-24
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ada temanku yang menyukai salah satu murid angklung saung udjo
Última actualización: 2024-02-14
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jika anda kembali tossin dan anda re turnin dan anda hanya tidak bisa tertidur akuakan menyanyikan lagu di samping anda
you can count on me like 123 l'll be there
Última actualización: 2022-05-31
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lumba lumba hidup dan bekerja dalam kelompok atau disebut kawanan. mereka sering bermain bersama. seekor lumba lumba tidak bisa tidur nyenyak di bawah air. ia bisa tenggelam. oleh karena itu, ia setengah tidur beberapa saat dalam sehari.
dolphins live and work in groups or called herds. they often play together. a dolphin can't sleep soundly underwater. it could sink. therefore, he half slept a few moments in a day.
Última actualización: 2022-02-22
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