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proovilahuse happeliste säilitusainete sisalduse arvutamiseks kasutatakse uuritavate säilitusainete piikide kõrguste ja 2-metoksübensoehappe piigi kõrguse suhet ning kalibreerimisgraafikut.
use the ratios of the heights of the peaks of the investigated preservatives to the height of the 2-methoxybenzoic acid (internal standard) peak and the calibration graph to calculate the concentration of the acid preservatives in the sample solution.
in vitro uuringud näitasid, et eluksadoliin oli inimese hepatotsüütides ning maksa ja soole mikrosoomides stabiilne ning et eluksadoliini ainus tuvastatud väheoluline ja inaktiivne metaboliit oli atsüülglükuroniid-metaboliit (m11), mis moodustus metoksübensoehappe osa glükuronidatsiooni kaudu.
in vitro studies demonstrated that eluxadoline was stable in human hepatocytes, liver and intestinal microsomes, and that the only minor and inactive metabolite of eluxadoline detected was the acyl glucuronide metabolite (m11) formed through glucuronidation of the methoxybenzoic acid moiety.